2015 American Transplant Congress

May 2-6, 2015 in Philadelphia, Pennsylvania

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Macrophage Specific β-Catenin Controls ROCK/PTEN Function and Regulates Innate Immunity in Liver Inflammation

S. Yue,¹ X. Zhou,² M. Zhou,¹ Y. Zhai,¹ R. Busuttil,¹ Q. Ying,² J. Kupiec-Weglinski,¹ B. Ke.¹
Macrophage-Specific SIRT1 Regulates HO-1 Mediated Anti-Inflammatory and Cytoprotective Pathways

K. Nakamura,¹ M. Zhang,² B. Ke,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
Maintaining Immunosuppressive Treatment After Early Allograft Nephrectomy Does Not Reduce the Risk of Anti-HLA Allo-Sensitization

A. Del Bello,^1,2 N. Congy-Jolivet,^2,3,4 I. Cardeau-Desangles,¹ C. Guilbeau-Frugier,^2,5 E. Pambrun,¹ G. Dörr,¹ O. Milioto,⁶ L. Esposito,¹ L. Rostaing,^1,2,7 N. Kamar.^1,2,7
Management of Pancreas Graft Splenic Vein Thrombosis: Is Conservative Management Safe?

J. Harbell,¹ T. Morgan,² V. Feldstein,² G. Roll,¹ A. Posselt,¹ S.-M. Kang,¹ S. Feng,¹ R. Hirose,¹ C. Freise,¹ P. Stock.¹
Marked Suppression of Posttransplant Alloantibody Production and Primed B cell Function In Vivo by mTOR Inhibition Compared to Calcineurin Inhibition

C. Wright, J. Zimmerer, T. Pham, G. Bumgardner.
Marrow Mesenchymal Stem Cells Attenuate Immune Rejection in Murine Lung Allograft

X. Zhang,¹ Y. Gong,² K. Jiang,² C. Wang,² T. Xia,² J. Li,² J. Wang,² J. Nie.²
Matching of Recipient and Donor Age Is the Most Powerful Risk Factor Affecting to Long-Term Graft Survival and Function

J. Lee,^1,2 Y. Lee,² J. Lee,^1,2 D. Joo,^1,2 K. Huh,^1,2 S. Kim,^1,2 Y. Kim,^1,2 M. Kim.^1,2
Matching Strategies in Kidney Paired Donation: A 7-Year Analysis of a Multi-Institutional Registry

D. Fumo,^1,2 L. Reece,² S. Stepkowski,¹ V. Kapoor,¹ S. Rees,² J. Kopke,² M. Rees.^1,2
Maximizing Peri-Operative Value-Based Care in Kidney Transplant Induction

J. Fleming,¹ J. Casale,¹ K. Covert,¹ K. Boyle,¹ D. Taber,² H. Meadows,¹ C. Mardis,¹ N. Pilch,¹ M. Posadas-Salas,³ T. Srinivas,³ C. Bratton,² J. McGillicuddy,² K. Chavin,² P. Baliga.²
MDRD4 Equation Is Better Than CKD-EPI, Cockroft-Gault and Nankivell Equations to Estimate Glomerular Filtration Rate in Renal Transplantation

E. David-Neto,¹ A. Triboni,¹ F. Ramos,¹ F. Agena,¹ F. Lemos,¹ M. Sapienza,² W. Nahas.¹
MDSC Derived from iPS Cells Regulate the CD8 T Cell Response In Vivo

D. Joyce,¹ M. Morita,² X.-K. Li,³ J. Fung,¹ S. Qian,^1,2 L. Lu.^1,2
Measuring Affinity of Polyclonal HLA-Specific Antibodies in Highly Sensitised Cases Can Serve as an Additional Biomarker to Guide Direct Transplantation

S. Daga,^1,2 D. Lowe,⁶ R. Buchli,³ J. Collard,³ A. Mulder,⁸ C. McMurtrey,^3,4 H. Moyse,⁷ N. Evans,⁷ N. Krishnan,² W. Hildebrand,^3,4 F. Claas,⁸ D. Briggs,⁵ D. Zehnder,^1,2 D. Mithcell,¹ R. Higgins.^1,2
Mechanisms Underlying Treg Dysfunction in DAIH- Role for PD-L1?

A. Arterbery,¹ M. Martinez,² S. Lobritto,² Y. Avitzur,³ K. Raddassi,¹ M. Kleinewietfeld,⁴ U. Ekong.¹
Medication Adherence and Treatment Satisfaction in Liver Transplant Recipients

A. Albekairy,¹ A. Alkatheri,² N. Khalidi,² K. Thiab,¹ A. Jarab,² A. Qandil,³ A. Alshaya,² K. BinSaleh.²
Medication Adherence in Adolescents With Kidney Transplant and Chronic Kidney Disease: Patient/Caregiver Report Vs. Provider Perception

C. Pruette,¹ T. Brady,¹ S. Mendley,² B. Fivush,¹ S. Tuchman,³ A. Green,¹ M. Eakin,¹ K. Riekert.¹
Medication Non-Adherence in Those Waiting for a Transplant

M. Wakefield,¹ D. Murillo,² C. Russell,³ C. Ashbaugh,¹ S. Potts,² L. Blakley,² A. Deere.¹
MELD as a Predictor of Post-Transplant Survival

X. Luo, A. Massie, A. Poon, D. Segev.
MELD Velocity – An Early Predictor of Increased Mortality Risk

D. Ladner,¹ K. Skibba,² J. Kang,¹ B. Ho,¹ A. Kho,¹ L. Kulik,¹ A. Daud,¹ M. Abecassis,¹ A. Skaro.¹
MELD/PELD 35+ Candidates Benefit from Regional Sharing

E. Edwards,¹ A. Harper,¹ R. Hirose,² D. Mulligan.³
Membranoproliferative Glomerulonephritis After Kidney Transplantation: A Single Center Experience

S. Alasfar, N. Carter-Monroe, A. Rosenberg, R. Montgomery, N. Alachkar.
Mesenchymal Stem Cell Therapy to Improve Functional Outcome in Vascular Composite Allotransplantation (VCA)

S. Salgar, J. Bingham, M. DeHart, J. Tercero, T. Brown.
Mesenchymal Stem Cells (MSCs) Transfusion for Desensitization of Positive Lymphocyte Cross Match (LCM) or Panel Reactive Antibodies (PRA) Before Kidney Transplantation – Outcome of 16 Cases

G. Saadi,¹ K. Eweda,² M. Hassaballa,¹ F. Fadel,³ E. Aziz,² M. Roshdi,¹ M. El Ansary,⁴ I. Aziz,⁴ W. Ismail,⁵ A. Atef,¹ S. Hamid.⁴
Mesenchymal Stem Cells Enhance Rejection Free and Overall Islet Allograft Survival

N. Kenyon,¹ M. Willman,¹ H. Dongmei,¹ H. Ana,¹ A. Rabassa,¹ W. Diaz,¹ J. Geary,¹ N. Kenyon,¹ A. Bartholomew,² K. McHenry,³ D. Salomon,⁴ D. Berman.¹
Mesenchymal Stem Cells Prevent Cold Ischemia-Reperfusion Injury in Lung Transplants

H. Wang,^1,2 W. Tian,¹ Y. Liu,³ X. Dai,¹ G. Li,³ T. Liu,^1,2 Z. Zhang,^1,2 C. Du.⁴
Mesenchymal Stem Cells Suppress Cytotoxicity of Activated Natural Killer Cells in Liver Via the TRAIL-TRAIL Receptor Pathway in Islet Transplantation

N. Ishida, K. Ishiyama, F. Hirata, Y. Saeki, Y. Tanaka, H. Ohdan.
Mesenchymal Stromal Cells (MSCs) Given Post-Transplant Together With C3a and C5a Receptor Antagonists Prevent Engraftment Syndrome and Induce a Mild Not-Significant Prolongation of Graft Survival

F. Casiraghi,¹ M. Todeschini,¹ N. Azzollini,¹ P. Cravedi,² P. Heeger,² P. Cassis,¹ S. Solini,¹ N. Perico,¹ M. Noris,¹ G. Remuzzi.¹
Metabolomic Analysis of Remote Ischemic Preconditioning in Renal Ischemia Reperfusion Injury

A. Han,¹ S.-I. Min,¹ K. Cho,² C. Choi,¹ S.-K. Min,¹ S. Kim,³ M. Park,⁴ J.-Y. Cho,² J. Ha.¹
Metrics of Global Health Status Signal Early Hospital Readmission Risk After Kidney Transplantation

M. Harhay,¹ A. Hill,² W. Wang,² O. Even-Shoshan,² A. Mussell,¹ J. Karlawish,³ R. Bloom,¹ H. Feldman,¹ J. Silber,² P. Reese.¹
MHC-Class-II Specific Sensitization in a Non-Human Primate Model of Sensitzation

C. Burghuber,^1,2 J. Kwun,¹ A. Gibby,¹ N. Iwakoshi,¹ S. Knechtle.¹
Microchimerism-Tolerance “Missing Link”: Exosome Acquisition by Host Dendritic Cells

W. Bracamonte-Baran, E. Jankowska-Gan, Y. Zhou, W. Burlingham.
Microcirculation Inflammation in Early Surveillance Renal Biopsy in Sensitized Patients Did Not Correlate With Graft Outcome

P. Souza,¹ D. Machado,¹ D. David,¹ G. Bezerra,¹ F. Jota de Paula,¹ H. Rodriges,² W. Nahas,¹ E. David Neto,¹ M. Castro.¹
MicroRNA (miR) 144 Dysregulates TGFβ Signaling Cascade and Contributes to Development of BOS Following Human Lung Transplantation

Z. Xu,¹ S. Ramachandran,¹ D. Nayak,¹ M. Gunasekaran,¹ E. Trulock,¹ R. Hachem,¹ D. Kreisel,¹ T. Mohanakumar.¹
MicroRNA let-7i Targeting IL-10 Via JAK1-STAT3 Signal Pathway Regulates Dendritic Cells Maturation Subsequently Induces Cardiac Allograft Tolerance

J. Wu,^2,3 X. Jin,¹ Y. Sun,^2,3 X. Liu,^2,3 D. Chi,^2,3 B. Yu.^2,3
MicroRNA-21 (miR-21) Expression in Hypothermic Machine Perfusate May Predict Early Outcomes in Kidney Transplantation

U. Khalid,^1,2 E. Ablorsu,² L. Szabo,² R. Jenkins,¹ T. Bowen,¹ D. Fraser,¹ R. Chavez.^1,2
microRNA-494 Promotes Cyclosporine-Induced Nephrotoxicity and Epithelial to Mesenchymal Transition By Inhibiting PTEN

J. Yuan,¹ C. Benway,^1,2 J. Bagley,¹ J. Iacomini.^1,2
MicroRNAs in Kidney Graft Preservation Fluid as Novel Biomarkers for Delayed Graft Function

L. Ooms, H. Roest, S. van den Hoek, R. de Bruin, J. IJzermans, L. van der Laan, F. Dor.
Microvascular (MIA) and Interstitial (i) Inflammation Influence Late Death-Censored Graft Failure (DCGF) After Kidney Transplantation

R. Gaston,¹ A. Fieberg,² R. Leduc,² J. Connett,² F. Cosio,³ S. Gourishankar,⁴ J. Grande,³ L. Hunsicker,⁵ B. Kasiske,⁶ J. Cecka,⁷ A. Matas,² D. Rush.⁸
Microvascular Inflammation in Early Protocol Biopsies of Renal Allografts in Cases of Chronic Active Antibody-Mediated Rejection

T. Tsuji,¹ M. Yanai,¹ H. Itami,¹ Y. Ishii,¹ M. Akimoto,¹ N. Fukuzawa,² H. Harada,² Y. Fukasawa.¹
miR-155 Different Roles in UCB iTreg and nTreg

Y. Lu, L. Lu.
MiR-26a Regulates Mouse Hepatocyte Proliferation By Directly Targeting Their 3′ Untranslated Region of CCNE2/CCND2

J. Zhou, X. Yuan, W. Ju, X. Jiao, X. Wang, M. Han, D. Wang, X. Zhu, X. He.
miRNA-181 Promotes Graft Prolongation by Plasmacytoid Dendritic Cells By Increasing T Regulatory Cells and Decreasing B Cells as Revealed By Cytometry By Time-Of-Flight

A. Lau,^1,2 M. Vitalone,¹ X. Qu,¹ T. Shawler,¹ O. Martinez,¹ C. Esquivel,¹ S. Krams.¹
Mitochondrial Feedback Mechanisms in Kidney Cell Senescence

K. De Vusser,¹ K. Hochstenbach,² E. Winckelmans,² E. Lerut,³ D. Kuypers,¹ T. Nawrot,² M. Naesens.¹
Mitochondrial Hydrogen Sulphide Donor Molecules Are More Effective Against Hypoxic Injury in Renal Tubular Epithelial Cells

G. Aboalsamh,^1,5 M. Saha,² I. Lobb,² J. Grewal,² P. Luke,^1,2,3 M. Wood,⁴ M. Whiteman,⁴ A. Sener.^1,2,3
Modeling the Clinical and Cost-Effectiveness of Dobutamine Stress Echocardiography With Confirmatory Coronary Angiography for the Diagnosis of Pediatric Cardiac Allograft Vasculopathy

D. Nandi, M. O'Connor, K. Lin, S. Paridon, C. Ravishankar, C. Mascio, R. Shaddy, J. Rossano.
Moderate KDPI (35-85) and High KDPI (>85) Grafts Yield Similar Graft Function and Survival

A. Gupta,² G. Francos,² C. Gorn,³ A. Shah.¹
Moderate Rejection Episode of Face Transplant After mTOR Conversion to Preserve Renal Function

R. Barth,¹ B. Bojovic,¹ J. Woodall,¹ M. Uluer,¹ C. Drachenberg,¹ C. Shaffer,¹ N. Kelly,¹ E. Rodriguez,² S. Bartlett.¹
Modified Upper Abdominal Organ Cluster Transplantation: A Serial of 16 Cases in a Single Center

J. Zhou, W. Ju, X. Yuan, D. Wang, X. Zhu, X. He.
Molecular and Functional Immune Assays as Non-Invasive Diagnostic Tools to Assess the Risk of Acute Subclinical Rejection After Kidney Transplantation

O. Bestard,^1,2 E. Crespo,¹ T. Sigdel,² S. Roedder,² Y. Ng,² J. Cruzado,¹ M. Lúcia,¹ S.-C. Hsieh,¹ T. Tran,¹ J. Grinyó,¹ M. Sarwal.¹
Molecular Classifiers Accurately Measure the Degree of Fibrosis in Human Kidney Transplant Biopsies

J. Venner, J. Reeve, P. Halloran.
Molecular Correlates of Atrophy-Fibrosis in Human Kidney Transplants Provides a New Model of Renal Fibrosis

J. Venner, K. Famulski, P. Halloran.
Molecular Correlates of Endothelial mTOR Activation in Heart Transplants Recipients

M. Racape, A. Loupy, J. Reeve, J. Venner, R. Guillemain, L. Hidalgo, C. Lefaucheur, X. Jouven, P. Bruneval, P. Halloran, J. Duong.
Molecular Features of Isolated Arteriolar Hyalinosis in Renal Transplant Biopsies

L. Kamal, P. O Broin, Y. Bao, A. Golden, E. Akalin.
Molecular Features of Kidney Transplant Biopsies Without Allograft Injury in Relation With Type of Induction Therapy

M. Ajaimy,¹ P. O Broin,² M. Lubetzky,¹ Y. Bao,¹ A. Golden,² E. Akalin.¹
Molecular Marker Strategies Supporting the Novartis US92 Study- A Discovery Study of Protein Biomarkers for Kidney Function (eGFR) and Acute Rejection in Serum from Renal Transplant Patients

U. Christians,¹ J. Klepacki,¹ A. Karimpour-fard,¹ G. Ingle,² D. Patel,² K. Johnson,³ D. Cibrik,³ J. Klawitter.¹
Molecular Testing for Microcirculation Injury Enhances the Assessment of Antibody-Mediated Rejection in Human Cardiac Allograft Biopsies

B. Afzali,¹ E. Chapman,¹ B. Adam,¹ F. Riesgo Gil,² D. Kim,² L. Hidalgo,¹ P. Campbell,¹ B. Sis,¹ M. Mengel.¹
Monitoring Intracellular Tacrolimus Concentration in Kidney Transplant Recipients With Stable Graft Function

E. Bae,¹ S. Han,¹ S. Yang,² J. Park,¹ H. Lee,¹ J. Lee,³ D. Kim,¹ Y. Kim.¹
Monocyte Recruitment to HLA Class I Antibody-Activated Endothelial Cells Is Dependent Upon mTOR

S. Salehi, E. Reed.
Mononuclear Cell Infiltrates Characterization in Scar Tissue from a Bilateral Forearm Transplant Patient: Findings to Think

J. Furuzawa-Carballeda,¹ M. Iglesias,² J. Alberu,³ A. Gamboa,⁴ P. Butrón,² M. Morán-Romero,² Y. Esquivel.¹
Month 48 Follow-Up Results of HERAKLES Trial on Three Different Treatment Regimen and Switching Off Behaviour in De Novo Renal Transplant Patients

W. Arns,¹ K. Budde,¹ C. Sommerer,¹ O. Witzke,¹ M. Guba,¹ J. Jacobi,¹ B. Vogt,³ P. Reinke,¹ I. Hauser,¹ R. Stahl,¹ T. Rath,¹ D. Baeumer,² M. Porstner,² M. Zeier,¹ F. Lehner,¹ V. Kliem.¹
Morphometric Age as a Predictor of Survival Following Kidney Transplantation

M. Terjimanian,¹ D. Cron,¹ D. Cote,² J. Augustine,² K. Noon,² S. Wang,¹ M. Englesbe,¹ K. Woodside.²
Morphometry of the Epithelial-Mesenchymal Transition (EMT) in Subsequent Biopsies from Transplanted Kidney

R. Świder, A. Perkowska-Ptasińska, A. Stachurska, J. Fabijańska-Mitek, R. Zagożdżon, S. Gruca, J. Gołąb, M. Durlik.
mTOR Inhibitors Reduce the Endothelial Transmigration of Leukocytes After Ischemia

I. Werner, A. Hernandez-Sierra, F. Guo, A. Moritz, A. Beiras-Fernandez.
mTOR-Based CNI Minimization Vs Withdrawal in African American Kidney Transplant Recipients

J. Fleming,¹ D. Taber,² N. Pilch,¹ H. Meadows,¹ C. Mardis,¹ J. McGillicuddy,² S. Nadig,² K. Chavin,² P. Baliga,² C. Bratton.²
Multicenter Study to Develop a Novel Prediction Index for Hepatocellular Carcinoma (HCC) Recurrence After Liver Transplant (LT)

N. Mehta,¹ J. Heimbach,² D. Harnois,³ J. Dodge,¹ J. Burns,³ D. Lee,³ W. Sanchez,² J. Roberts,¹ F. Yao.¹
Multicenter Validation of a Molecular Diagnostic for Antibody-Mediated Rejection in Formalin-Fixed Paraffin-Embedded Human Renal Allograft Biopsies

B. Adam,¹ B. Afzali,¹ N. Shah,¹ K. Dominy,² R. Gill,¹ L. Hidalgo,¹ P. Campbell,¹ C. Roufosse,² M. Mengel,¹ B. Sis.¹
Multivisceral Transplantation Without an Ostomy – Experience With 15 Patients

T. Beduschi, J. Garcia, S. Nishida, A. Tekin, J. Fan, G. Selvaggi, P. Ruiz, R. Vianna.
Murine Veno-Arterial Extracorporeal Membrane Oxygenation (mVA-ECMO): A Novel Tool to Study the Molecular Biology of Mechanical Circulatory Support

A. Schenk,¹ J. Fallon,¹ M. Farrell,¹ R. Halter,² J. Yun.³
Muscle Mass Measurement Is Objective and More Predictive of Expected Mortality Than Functional Status in High MELD Liver Transplant Recipients

J. Nolte,¹ S. Gordon Burroughs,¹ D. Victor,¹ C. Mobley,¹ N. Yu,² T. Hirase,¹ A. Saharia,¹ A. Rajaraman,¹ L. Moore,¹ A. Gaber,¹ R. Ghobrial.¹
Mycophenolate Dose Reductions Contribute to Suboptimal Graft Outcomes in Kidney Transplant Recipients

K. Boyle, J. Fleming, D. Taber, K. Covert, J. Casale, C. Staino, N. Pilch, C. Mardis, H. Meadows, T. Srinivas, J. McGillicuddy, K. Chavin, C. Bratton, P. Baliga.
Mycophenolic Acid Area-Under-Curve (MPA AUC) Levels Sufficient to Prevent Donor-Specific Antibody (DSA) Formation Are Not Associated With Higher Rates of CMV/EBV/BK Viral Infections

S. Narins, D. Ladie, R. Saylor, E. Richards, H. Yang, M. Waybill.
Myeloid Cell-Specific Heme Oxygenase-1 Is Crucial for Hepatoprotection in Liver Ischemia-Reperfusion Injury

K. Nakamura,¹ M. Zhang,² B. Ke,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
Myeloid Cells as a Key Mediator for Impairment of Transplant Tolerance by CMV Infection

L. Zhang,¹ X. Zhang,² H. Kang,¹ X.-F. Liu,² S. Yan,² J.-J. Wang,² M. Abecassis,² Z. Zhang,² M. Hummel,² X. Luo.^1,2
MYH9 Polymorphic Variants and Chronic Lesions in Transplanted Kidney Biopsy

J. Pazik,¹ M. Oldak,² Z. Lewandowski,³ D. Ozieblo,⁴ K. Michalska,⁵ A. Perkowska Ptasińska,¹ A. Sadowska,¹ M. Nowaczyk,⁵ J. Malejczyk,⁴ M. Durlik.¹

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