ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Muscle Mass Measurement Is Objective and More Predictive of Expected Mortality Than Functional Status in High MELD Liver Transplant Recipients

J. Nolte,1 S. Gordon Burroughs,1 D. Victor,1 C. Mobley,1 N. Yu,2 T. Hirase,1 A. Saharia,1 A. Rajaraman,1 L. Moore,1 A. Gaber,1 R. Ghobrial.1

1Surgery, Houston Methodist Hospital, Houston, TX
2Radiology, Houston Methodist Hospital, Houston, TX.

Meeting: 2015 American Transplant Congress

Abstract number: 109

Keywords: High-risk, Liver transplantation, Mortality

Session Information

Date: Sunday, May 3, 2015

Session Name: Concurrent Session: Liver Retransplantation and Other Complications

Session Time: 4:00pm-5:30pm

 Presentation Time: 5:00pm-5:12pm

Location: Room 115-AB

Related Abstracts
  • Functional Status Predicts Mortality After Liver Transplant
  • Comparison of Liver Transplant Outcomes for Recipients With MELD <35 Vs. >35

Introduction: Calculations used to determine expected survival post-liver transplant (OLT) are in part based on pre-OLT functional status. Functional status is subjectively measured by Karnofsky Index (KI) and correlates poorly with mortality in the highest acuity candidates. We sought to determine whether degree of sarcopenia as measured by average psoas area could better predict risk of post-OLT mortality within a subset of high model of end-stage liver disease (MELD) score candidates.

Methods: We retrospectively evaluated 57 patients with MELD scores ≥25–49 who were transplanted 2008-2013 with pre-transplant cross sectional imaging and KI ≤40%. Muscle mass was measured as average psoas area at L3. Patients were divided into tercile groups based on high (10.13 cm2 [Group A]), medium (6.29 cm2 [Group B]), and low (4.39 cm2 [Group C]) mean psoas areas. Post-operative outcomes including mortality, time to KI >70%, and post-OLT ICU length of stay (LOS) were compared.

Results: Despite equivalent MELD and KI's between all terciles (Table 1), Group C mortality was highest (35.3% vs 10.0% in A and B, p<0.05). There was no statistical significance between groups for Days to KI >70%, however, a trend exists for longer time in Group C compared to Groups A and B. ICU LOS was significantly less in Group C compared to Groups A and B (p<0.05).

Outcomes of psoas tercile Groups A, B and C
Tercile Group Mean psoas area(cm2) Mean MELD [SD] Mortality (%) ICU LOS (days [SD] Time to >70% Karnofsky index (days [SD]) Mean Karnofsky Index at listing
A (n=20) 10.13 37 [6] 10 27.1 183.1 [185] 45
B (n=20) 6.29 38 [6] 10 26.6 148.1 [127.4] 45
C (n=17) 4.39 35 [6] 35.3 18.8 248 [303.6] 41
Conclusion: Though all groups had equivalent MELDs and poor pre-OLT KI, extreme sarcopenia was associated with highest mortality and longest time to functional recovery. Objective muscle mass measurement, a better reflection of the extreme depletion of muscle stores seen in high MELD patients, may be a better predictor of mortality and thus expected survival than KI.

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Nolte J, Burroughs SGordon, Victor D, Mobley C, Yu N, Hirase T, Saharia A, Rajaraman A, Moore L, Gaber A, Ghobrial R. Muscle Mass Measurement Is Objective and More Predictive of Expected Mortality Than Functional Status in High MELD Liver Transplant Recipients [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/muscle-mass-measurement-is-objective-and-more-predictive-of-expected-mortality-than-functional-status-in-high-meld-liver-transplant-recipients/. Accessed April 15, 2021.

« Back to 2015 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Home
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Home
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.