Date: Saturday, May 2, 2015
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Exhibit Hall E
Anti-HLA immunization is greatly increased after early kidney-allograft failure, even if the graft is removed within a few hours post-transplantation. The aim of our study was to compare the incidence of anti-HLA antibodies in patients who were continued immunosuppression for three months after early allograft failure and a nephrectomy (within <1 week) and those who were weaned off immunosuppression.
Group 1: between 2007 and 2012, 21 patients who had early graft loss were weaned off immunosuppression immediately. Group 2: between 2012 and 2013, 11 patients with allograft nephrectomy were given tacrolimus (target trough level 46 ng/mL), mycophenolate mofetil (1 g/d), and steroids for three months. The median time between transplantation and nephrectomy was similar in both groups (1  and 1  days).
The rate of HLA sensitization was similar in both groups at transplantation and none had pre-formed donor-specific antibodies (DSA). At month 12, the incidences of DSA and non-DSA anti-HLA antibodies were 82% and 82% in the immunosuppression group, and 74% and 78% in patients who received no immunosuppression. More complications were observed in patients that received immunosuppression.
Prolonged immunosuppression after early graft failure does not prevent anti-HLA immunization and it also increases the risk of complications.
To cite this abstract in AMA style:Bello ADel, Congy-Jolivet N, Cardeau-Desangles I, Guilbeau-Frugier C, Pambrun E, Dörr G, Milioto O, Esposito L, Rostaing L, Kamar N. Maintaining Immunosuppressive Treatment After Early Allograft Nephrectomy Does Not Reduce the Risk of Anti-HLA Allo-Sensitization [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/maintaining-immunosuppressive-treatment-after-early-allograft-nephrectomy-does-not-reduce-the-risk-of-anti-hla-allo-sensitization/. Accessed December 5, 2020.
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