ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Non-invasive diagnosis"

  • 2021 American Transplant Congress

    A Multimodal Interrogation of Human Renal Allografts

    D. Dadhania1, R. Ding1, H. Xu2, C. Lee1, C. Snopkowski1, T. Salinas1, T. Muthukumar1, J. Lee1, R. Woodward2, M. Grskovic2, S. Dholakia2, M. Suthanthiran1

    1Weill Cornell Medicine - NYPH, New York, NY, 2CareDx, New York, NY

    *Purpose: Development and validation of noninvasive biomarkers of kidney allograft rejection should improve transplant outcomes. CTOT-04 study validated urinary cell mRNA signature (CTOT04-Sig) for T-cell…
  • 2021 American Transplant Congress

    Association of Donor-Derived Cell-Free DNA with Severity of Interstitial Fibrosis and Cortical Atrophy Lesions Following Kidney Transplantation

    L. Bu1, E. Stites2, V. Bowers3, T. Alhamad4, J. S. Bromberg5, G. Gupta6, I. Moinuddin6, S. Ghosh7, W. Tian7, A. Pai8, S. Anand9

    1University of Minnesota, Minneapolis, MN, 2University of Colorado, Aurora, CO, 3Tampa General Hospital, Tampa, FL, 4Washington University in St. Louis, St. Louis, MO, 5University of Maryland School of Medicine, Baltimore, MD, 6Virginia Commonwealth University, Richmond, VA, 7CareDx, Brisbane, CA, 8University of Texas McGovern Medical School, Houston, TX, 9Intermountain Medical Center, Murray, UT

    *Purpose: The most common cause of kidney transplant (KT) failure is the poorly characterized histopathologic entity “interstitial fibrosis and tubular atrophy” (IFTA). There are no…
  • 2021 American Transplant Congress

    High Levels of Donor-Derived Cell-Free DNA Predict EGFR Decline After Kidney Transplantation

    T. Alhamad1, V. Bowers2, E. Stites3, S. Anand4, J. S. Bromberg5, H. Murad1, G. Gupta6, I. Moinuddin6, L. Bu7, S. Ghosh8, J. Zeng8, A. Pai9

    1Washington University in St. Louis, St. Louis, MO, 2Tampa General Hospital, Tampa, FL, 3University of Colorado, Aurora, CO, 4Intermountain Medical Center, Murray, UT, 5University of Maryland School of Medicine, Baltimore, MD, 6Virginia Commonwealth University, Richmond, VA, 7University of Minnesota, Minneapolis, MN, 8CareDx, Brisbane, CA, 9University of Texas McGovern Medical School, Houston, TX

    *Purpose: Persistent, low-grade inflammation is associated with decline in eGFR. Cross-sectional studies have demonstrated a consistent association between circulating inflammatory markers and kidney function. Our…
  • 2021 American Transplant Congress

    Benign Pneumatosis Intestinalis with Pneumoperitoneum in the Immunocompromised Patient: Three Cases

    A. Mohamed, K. Delvecchio, T. Kitajima, M. Rizzari, K. Collins, A. Yoshida, S. Nagai, J. Denny, M. Abouljoud

    Department of Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI

    *Purpose: Isolated pneumatosis intestinalis after solid organ transplantation, as well as its surgical management in appropriate clinical context, is a well described entity. The management…
  • 2021 American Transplant Congress

    Assessment of Donor-Derived Cell-Free DNA Performance Characteristics Across the Spectrum of TCMR and ABMR After Kidney Transplant

    L. Bu1, S. Anand2, A. Pai3, J. S. Bromberg4, T. Alhamad5, V. Bowers6, I. Moinuddin7, S. Ghosh8, W. Tian8, E. Stites9, G. Gupta7

    1University of Minnesota, Minneapolis, MN, 2Intermountain Medical Center, Murray, UT, 3University of Texas McGovern Medical School, Houston, TX, 4University of Maryland School of Medicine, Baltimore, MD, 5Washington University in St. Louis, St. Louis, MO, 6Tampa General Hospital, Tampa, FL, 7Virginia Commonwealth University, Richmond, VA, 8CareDx, Brisbane, CA, 9University of Colorado, Aurora, CO

    *Purpose: Different donor-derived cell-free DNA (dd-cfDNA) thresholds have been reported in association with varying TCMR, ABMR and “Borderline” diagnoses. Interpretation of dd-cfDNA levels spanning active…
  • 2020 American Transplant Congress

    The Urine Qisant Score: Non-Invasive, Accurate, Diagnosis and Prediction of Kidney Transplant Rejection

    J. Y. Yang1, R. Sarwal1, T. Sigdel1, I. Damm1, B. Rosenbaum1, J. Liberto1, C. Chan-On1, J. Alberu2, F. Vincenti1, M. M. Sarwal1

    1University of California San Francisco, San Francisco, CA, 2University of Mexico, Instituto Nacional De Ciencias Medicas y Nutricion, San Francisco, CA

    *Purpose: Accurate and non-invasive monitoring of renal allografts post-transplant is essential for early detection of acute rejection (AR) and to directly impact the long-term survival…
  • 2020 American Transplant Congress

    Antibody-Mediated Rejection with and without Donor-Specific Anti-HLA Antibodies: Performance of the Peripheral Blood 8-Gene Expression Assay

    E. Van Loon1, E. Lerut2, D. Anglicheau3, W. Gwinner4, M. Essig5, P. Marquet5, M. Naesens1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2KU Leuven, Leuven, Belgium, 3Department of Nephrology and Kidney Transplantation, Necker Hospital, Paris, France, 4Hannover Medical School, Hannover, Germany, 5CHU Limoges, Limoges, France

    *Purpose: Therapeutic implications of the recently discovered 8-gene expression assay are most clear for detection of antibody-mediated rejection in presence of donor-specific anti-HLA antibodies (HLA-DSA).…
  • 2020 American Transplant Congress

    Single Center Experience in Using Donor-Derived Cell-Free DNA in Kidney Transplant

    P. Homkrailas1, S. Lee2, B. Kandagedon1, G. Danovitch1, S. Bunnapradist1

    1Medicine, Division of Nephrology, Kidney and Pancreas Transplant Programs, UCLA, Los Angeles, CA, 2Department of Pharmacy, UCLA, Los Angeles, CA

    *Purpose: While the gold standard for diagnosing allograft rejection in kidney transplant recipients (KTX) continues to be histopathologic evaluation, it has been well recognized that…
  • 2020 American Transplant Congress

    Urinary CXCL10: From Diagnosis to Prediction of BK Viremia in Kidney Transplantation

    C. Tinel1, A. Vermorel1, D. Picciotto1, L. Morin1, C. Legendre1, M. Rabant2, D. Anglicheau1

    1Kidney Transplantation, Inserm U1151, Necker Hospital, Paris, France, 2Pathology, Necker Hospital, Paris, France

    *Purpose: Urinary CXCL10 (uCXCL10) has proved to be a useful tool for the non-invasive diagnosis of acute rejection in kidney transplant recipients (KTRs). Upon development,…
  • 2020 American Transplant Congress

    Integrated Multicohort Analysis of Transcriptome Profiles Identifies Blood Gene Signature to Distinguish Rejection from Infection in Patients with Solid Organ Transplants

    L. C. Murphy, A. Rao, M. Donato, P. Khatri

    School of Medicine, Stanford University, Stanford, CA

    *Purpose: Allograft rejection and infection are now leading causes of morbidity and mortality in transplant recipients. Current diagnosis relies on nonspecific markers of graft injury,…
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