2020 American Transplant Congress
Single Center Experience in Using Donor-Derived Cell-Free DNA in Kidney Transplant
*Purpose: While the gold standard for diagnosing allograft rejection in kidney transplant recipients (KTX) continues to be histopathologic evaluation, it has been well recognized that…2020 American Transplant Congress
Urinary CXCL10: From Diagnosis to Prediction of BK Viremia in Kidney Transplantation
*Purpose: Urinary CXCL10 (uCXCL10) has proved to be a useful tool for the non-invasive diagnosis of acute rejection in kidney transplant recipients (KTRs). Upon development,…2019 American Transplant Congress
Unique Gene Expression Signatures in Urine Distinguish T Cell Mediated Acute Rejection from BK Virus Nephropathy in Kidney Transplant Patients
*Purpose: There is a need to develop non-invasive approaches to detect ongoing kidney graft injury and distinguish immune from non-immune inflammation to guide therapy. Ideally…2019 American Transplant Congress
Correlation of Donor-Derived Cell-Free DNA with Histology and Molecular Diagnoses of Kidney Transplant Biopsies
1VCU Medical Center, Richmond, VA, 2Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada
*Purpose: Circulating donor-derived cell free DNA (cfDNA; Allosure, CareDx, USA), a non-invasive test that could detect rejection in kidney allografts was validated using histologic diagnoses(HDx).…2019 American Transplant Congress
Urinary Exosomal microRNA as a Non-Invasive Biomarker for the Diagnosis of Acute Rejection in Kidney Transplant Recipients
*Purpose: Acute rejection (AR) is the main obstacle to the graft survival after kidney transplantation. Urinary exosome is a promising source of biomarker for various…2019 American Transplant Congress
miRNA Signatures as Prediction Tool for DSA Development and Rejection
1Terasaki Research Institute, Los Angeles, CA, 2East Carolina University, Greenville, NC
*Purpose: Early and convenient diagnosis is urgently needed for acute and chronic transplant rejection due to its high risk of the loss of the transplant.…2019 American Transplant Congress
Alteration of Myocardial Velocities and T1 Times in Patients with Acute Cellular Rejection during First Year Post Heart Transplant
Northwestern University, Chicago, IL
*Purpose: We hypothesize that acute cellular rejection (ACR) episodes during the first year post heart transplant (HTx) may lead to structural and functional alterations of…2019 American Transplant Congress
Utility of Gallium-67 Single Photon Emission Computed Tomography in the Evaluation of Left Ventricular Assist Device Infections
*Purpose: We routinely use gallium-67 single photon emission computed tomography (67Ga-SPECT-CT) to determine the presence and extent of left ventricular assist device (LVAD) infections. The…2019 American Transplant Congress
Identification of Rare Genetic Disorders in Kidney Transplantation Recipients with Un-Diagnosed Nephropathy through NGS Approach
Emergency and Organ Transplantation, University of Bari, Bari, Italy
*Purpose: About 10% of end stage renal disease (ESRD) patients have no diagnosis of the primary kidney disease. Patients with unknown renal pathology can access…2019 American Transplant Congress
An 8-Gene Expression Assay in Peripheral Blood for Diagnosis of Antibody-Mediated Rejection after Kidney Transplantation
*Purpose: Antibody-mediated rejection is a leading cause of graft failure after kidney transplantation. The diagnosis of antibody-mediated rejection is made by combining assessment of circulating…
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