2022 American Transplant Congress
Can dd-cf DNA Eliminate Unnecessary Biopsies? The Answer is Yes!
University Hospitals Cleveland Medical Center, Cleveland, OH
*Purpose: Historically our center has been one that routinely performs biopsies. We perform them pre-perfusion, for slowly recovering allografts between day 10-14, and routinely at…2022 American Transplant Congress
Interleukin-31 (IL-31) and Leukemia Inhibitory Factor (LIF) Are Upregulated in Acute Rejection of Kidney Allograft
Institute for Clinical and Experimental Medicine, Praha, Czech Republic
*Purpose: Interleukin-31 (IL-31) and leukemia inhibitory factor (LIF) belong to the IL-6 cytokine family clustered by their pro-inflammatory properties and a shared signaling pathway of…2022 American Transplant Congress
Can Fibroscan Evaluation Of A Liver Predict Transplantability As Accurately As A Biopsy?
*Purpose: Liver transplants are essential procedures that can impact a patient with chronic liver disease’s overall survival. Historically liver biopsies are the gold standard in…2022 American Transplant Congress
Tissue Engineering Scaffolds for Minimally Invasive Immunosurveillance of Acute Cellular Graft Rejection
*Purpose: As there is no assay to predict the risk of acute cellular allograft rejection (ACAR), clinicians rely on protocol graft biopsy and aggressive, one-size-fits-all…2022 American Transplant Congress
Infection Impacts dd-cfDNA in Lung Transplant Recipients
*Purpose: Infection is the leading cause of death within 1 year post lung transplant. Graft injury secondary to infection is affected by both source and…2022 American Transplant Congress
Bone Mineral Density, Bone Micro-Architecture Evolution After Kidney Transplantation: A Prospective Cohort Study
*Purpose: Bone loss and mineral abnormalities are frequent in kidney transplant recipients (KTRs) and associated with a high risk of fracture and cardiovascular mortality. In…2021 American Transplant Congress
Trugraf Gene Expression Testing Can Discriminate Rejection in the Setting of Acute Kidney Injury
*Purpose: The TruGraf kidney blood gene expression test is a well-validated non-invasive biomarker to detect immune quiescence thus ruling out silent subclinical rejection in stable…2021 American Transplant Congress
Comparison of Next Generation Sequencing Donor-derived Cell Free DNA Assay Utilizing Whole Genome Sequencing
*Purpose: Circulating donor-derived cell free DNA (dd-cfDNA) is a non-invasive biomarker of kidney allograft injury with a high negative predictive value for ruling out acute…2021 American Transplant Congress
Nonadherence Post-kidney Transplant is Associated with Increased Immune Activation Detected by Peripheral Blood Gene Expression Assay
*Purpose: Nonadherence to immunosuppression medications is common post-transplantation. We hypothesize that nonadherence results in a heightened alloimmune response in kidney transplant recipients (KTRs) which in…2021 American Transplant Congress
Donor-Derived Cell-Free DNA Performance Characteristics are Similar for Repeat and Primary Kidney Transplant Recipients
*Purpose: Repeat kidney transplants (RKT) represent 12.4% of kidney transplants (KT) (10.9% of all living donor and 13.6% of all deceased donor). Most RKT are…
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