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Articles tagged "Non-invasive diagnosis"

  • 2022 American Transplant Congress

    Can Fibroscan Evaluation Of A Liver Predict Transplantability As Accurately As A Biopsy?

    S. J. Sander1, M. Moncure2

    1Organ Procurement, Midwest Transplant Network, Westwood, KS, 2Midwest Transplant Network, Westwood, KS

    *Purpose: Liver transplants are essential procedures that can impact a patient with chronic liver disease’s overall survival. Historically liver biopsies are the gold standard in…
  • 2022 American Transplant Congress

    Tissue Engineering Scaffolds for Minimally Invasive Immunosurveillance of Acute Cellular Graft Rejection

    R. R. Urie1, D. Farris2, A. Morris1, E. Lombard1, J. Z. Li3, D. Goldstein2, L. Shea1

    1Biomedical Engineering, University of Michigan, Ann Arbor, MI, 2Internal Medicine, University of Michigan, Ann Arbor, MI, 3Human Genetics, University of Michigan, Ann Arbor, MI

    *Purpose: As there is no assay to predict the risk of acute cellular allograft rejection (ACAR), clinicians rely on protocol graft biopsy and aggressive, one-size-fits-all…
  • 2022 American Transplant Congress

    Infection Impacts dd-cfDNA in Lung Transplant Recipients

    D. Levine1, C. Giner1, C. Pham2, R. Woodward2, A. Roux3

    1University of Texas Health System San Antonio, San Antonio, TX, 2CareDX, South San Francisco, CA, 3Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France

    *Purpose: Infection is the leading cause of death within 1 year post lung transplant. Graft injury secondary to infection is affected by both source and…
  • 2022 American Transplant Congress

    Bone Mineral Density, Bone Micro-Architecture Evolution After Kidney Transplantation: A Prospective Cohort Study

    A. Bouquegneau, O. Malaise, L. Seidel, L. Weekers, C. Bonvoisin, F. Jouret, E. Cavalier, P. Delanaye

    CHU de Liège, Liege, Belgium

    *Purpose: Bone loss and mineral abnormalities are frequent in kidney transplant recipients (KTRs) and associated with a high risk of fracture and cardiovascular mortality. In…
  • 2022 American Transplant Congress

    A Sign of Things to Come? Clinical Markers After Elevated Donor-Derived Cell-Free DNA in Heart Transplant Recipients

    D. T. Kim1, E. J. Henricksen2, B. M. Zhang3, J. J. Teuteberg1, Y. Moayedi4, H. I. Luikart1, J. Han5, B. Wayda1, K. Khush1

    1Cardiology, Stanford University, Stanford, CA, 2Transplant, Stanford Health Care, Stanford, CA, 3Pathology, Stanford University, Stanford, CA, 4Cardiology, University Health Network, Toronto, ON, Canada, 5Cardiology, University of Chicago, Chicago, IL

    *Purpose: Endomyocardial biopsy (EMBx) has historically been the standard of care for surveillance post heart transplant (HTx), but is limited by sample area and interpretation.…
  • 2022 American Transplant Congress

    Nonadherence Post-Kidney Transplant is Associated with Increased Immune Activation Detected by Peripheral Blood Gene Expression Assay

    M. S. Naseer, H. Shokouh-Amiri, T. Creamer, R. McMillan, S. Tandukar, D. Aultman, G. B. Zibari, N. Singh

    Transplant, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA

    *Purpose: Nonadherence to immunosuppressive medications is common post-transplantation. We hypothesized that nonadherence results in a heightened alloimmune response in kidney transplant recipients (KTRs), which may…
  • 2021 American Transplant Congress

    Donor-derived Cell-free DNA in Upper Extremity Vascular Composite Allograft Recipients

    R. Kalsi1, M. Abuzeineh2, J. Littleton1, J. T. Shores1, D. S. Cooney1, C. Cooney1, R. J. Redett1, G. Brandacher1, D. C. Brennan2

    1Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD, 2Nephrology, Johns Hopkins University, Baltimore, MD

    *Purpose: Diagnosing rejection in VCA recipients relies on clinical exam and biopsy which are both easily confounded by common causes of skin irritation. dd-cfDNA in…
  • 2021 American Transplant Congress

    Donor-Derived Cell-Free DNA Performance Characteristics are Similar for Repeat and Primary Kidney Transplant Recipients

    V. R. Peddi1, S. Akkina2, S. C. Jordan3, W. Tian4, Y. Qazi5

    1California Pacific Medical Center, San Francisco, CA, 2Loyola University Medical Center, Maywood, IL, 3Cedars-Sinai Medical Center, Los Angeles, CA, 4CareDx, Brisbane, CA, 5University of Southern California, Los Angeles, CA

    *Purpose: Repeat kidney transplants (RKT) represent 12.4% of kidney transplants (KT) (10.9% of all living donor and 13.6% of all deceased donor). Most RKT are…
  • 2021 American Transplant Congress

    Nonadherence Post-kidney Transplant is Associated with Increased Immune Activation Detected by Peripheral Blood Gene Expression Assay

    N. Singh1, A. Palermini1, M. S. Naseer1, T. Le1, S. Tandukar1, D. Aultman2, H. Shokouh-Amiri2, G. Zibari2

    1Transplant, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, 2Advanced Surgery, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA

    *Purpose: Nonadherence to immunosuppression medications is common post-transplantation. We hypothesize that nonadherence results in a heightened alloimmune response in kidney transplant recipients (KTRs) which in…
  • 2021 American Transplant Congress

    Trugraf Gene Expression Testing Can Discriminate Rejection in the Setting of Acute Kidney Injury

    N. Singh1, M. S. Naseer1, D. Aultman2, H. Shokouh-Amiri2, G. Zibari2

    1Nephrology, John C. McDonald Regional Transplant Center - Willis Knighton Medical Center, Shreveport, LA, 2Advanced Surgery, John C. McDonald Regional Transplant Center - Willis Knighton Medical Center, Shreveport, LA

    *Purpose: The TruGraf kidney blood gene expression test is a well-validated non-invasive biomarker to detect immune quiescence thus ruling out silent subclinical rejection in stable…
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