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American Transplant Congress abstracts

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Articles tagged "Non-invasive diagnosis"

  • 2022 American Transplant Congress

    Can dd-cf DNA Eliminate Unnecessary Biopsies? The Answer is Yes!

    K. Andreoni, Y. Chalicheemala, M. Debroy, M. Maklad, K. Zhao, M. Aeder, A. Jittirat, D. Ecabert, A. Bixby, C. Burrelli, K. Chavin

    University Hospitals Cleveland Medical Center, Cleveland, OH

    *Purpose: Historically our center has been one that routinely performs biopsies. We perform them pre-perfusion, for slowly recovering allografts between day 10-14, and routinely at…
  • 2022 American Transplant Congress

    Interleukin-31 (IL-31) and Leukemia Inhibitory Factor (LIF) Are Upregulated in Acute Rejection of Kidney Allograft

    I. Striz, L. Krupickova, M. Fialova, M. Novotny, E. Cecrdlova, O. Viklicky

    Institute for Clinical and Experimental Medicine, Praha, Czech Republic

    *Purpose: Interleukin-31 (IL-31) and leukemia inhibitory factor (LIF) belong to the IL-6 cytokine family clustered by their pro-inflammatory properties and a shared signaling pathway of…
  • 2022 American Transplant Congress

    Can Fibroscan Evaluation Of A Liver Predict Transplantability As Accurately As A Biopsy?

    S. J. Sander1, M. Moncure2

    1Organ Procurement, Midwest Transplant Network, Westwood, KS, 2Midwest Transplant Network, Westwood, KS

    *Purpose: Liver transplants are essential procedures that can impact a patient with chronic liver disease’s overall survival. Historically liver biopsies are the gold standard in…
  • 2022 American Transplant Congress

    Tissue Engineering Scaffolds for Minimally Invasive Immunosurveillance of Acute Cellular Graft Rejection

    R. R. Urie1, D. Farris2, A. Morris1, E. Lombard1, J. Z. Li3, D. Goldstein2, L. Shea1

    1Biomedical Engineering, University of Michigan, Ann Arbor, MI, 2Internal Medicine, University of Michigan, Ann Arbor, MI, 3Human Genetics, University of Michigan, Ann Arbor, MI

    *Purpose: As there is no assay to predict the risk of acute cellular allograft rejection (ACAR), clinicians rely on protocol graft biopsy and aggressive, one-size-fits-all…
  • 2022 American Transplant Congress

    Infection Impacts dd-cfDNA in Lung Transplant Recipients

    D. Levine1, C. Giner1, C. Pham2, R. Woodward2, A. Roux3

    1University of Texas Health System San Antonio, San Antonio, TX, 2CareDX, South San Francisco, CA, 3Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France

    *Purpose: Infection is the leading cause of death within 1 year post lung transplant. Graft injury secondary to infection is affected by both source and…
  • 2022 American Transplant Congress

    Bone Mineral Density, Bone Micro-Architecture Evolution After Kidney Transplantation: A Prospective Cohort Study

    A. Bouquegneau, O. Malaise, L. Seidel, L. Weekers, C. Bonvoisin, F. Jouret, E. Cavalier, P. Delanaye

    CHU de Liège, Liege, Belgium

    *Purpose: Bone loss and mineral abnormalities are frequent in kidney transplant recipients (KTRs) and associated with a high risk of fracture and cardiovascular mortality. In…
  • 2022 American Transplant Congress

    A Sign of Things to Come? Clinical Markers After Elevated Donor-Derived Cell-Free DNA in Heart Transplant Recipients

    D. T. Kim1, E. J. Henricksen2, B. M. Zhang3, J. J. Teuteberg1, Y. Moayedi4, H. I. Luikart1, J. Han5, B. Wayda1, K. Khush1

    1Cardiology, Stanford University, Stanford, CA, 2Transplant, Stanford Health Care, Stanford, CA, 3Pathology, Stanford University, Stanford, CA, 4Cardiology, University Health Network, Toronto, ON, Canada, 5Cardiology, University of Chicago, Chicago, IL

    *Purpose: Endomyocardial biopsy (EMBx) has historically been the standard of care for surveillance post heart transplant (HTx), but is limited by sample area and interpretation.…
  • 2022 American Transplant Congress

    Nonadherence Post-Kidney Transplant is Associated with Increased Immune Activation Detected by Peripheral Blood Gene Expression Assay

    M. S. Naseer, H. Shokouh-Amiri, T. Creamer, R. McMillan, S. Tandukar, D. Aultman, G. B. Zibari, N. Singh

    Transplant, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA

    *Purpose: Nonadherence to immunosuppressive medications is common post-transplantation. We hypothesized that nonadherence results in a heightened alloimmune response in kidney transplant recipients (KTRs), which may…
  • 2022 American Transplant Congress

    dd-cfDNA Varies Among Diagnostics Groups of Pulmonary AMR

    D. Levine1, C. Giner1, C. Pham2, R. Woodward3, A. Roux4

    1University of Texas Health System San Antonio, San Antonio, TX, 2CareDX, South San Francisco, CA, 3CareDx, South San Francisco, CA, 4Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France

    *Purpose: Antibody mediated rejection (AMR) in lung transplant remains complex, with differential diagnosis often overlapping with other causes of lung dysfunction. Diagnostic certainty declines to…
  • 2022 American Transplant Congress

    The Unique Course of dd-cfDNA After Lung Transplant

    D. Levine1, C. Giner1, C. Pham2, R. Woodward3, A. Roux4

    1University of Texas Health System San Antonio, San Antonio, TX, 2CareDX, South San Francisco, CA, 3CareDx, South San Francisco, CA, 4Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France

    *Purpose: The time necessary for dd-cfDNA to reach baseline levels following transplantation has been reported in kidney, heart, and liver as 14-21 days. We explored…
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