2020 American Transplant Congress
Assessment of the Usefulness of Urine Signature to Differentiate Acute Rejection in a Prospective Kidney Transplantation Cohort
*Purpose: Despite many biomarker studies in the field of transplantation, development and validation of noninvasive molecular assays to diagnose disease and monitor immune activity is…2020 American Transplant Congress
Calibration of Donor-Derived Cell-Free DNA Criteria for Rejection with Molecular Diagnoses of Kidney Transplant Biopsies
*Purpose: Traditional microscopic histopathologic assessment (HDx) can be prone to error due to inter-observer variability as well as the non-specificity of some histologic lesions. Donor-derived…2020 American Transplant Congress
Urine Donor Derived Cell Free DNA Aids in the Diagnosis of BK Polyomavirus Nephropathy in Kidney Transplant Recipients with BK Viruria
*Purpose: BK polyomavirus nephropathy (BKVN) are important cause of dysfunction and failure of renal transplants, which is similar to T cell mediated rejection (TCMR) in…2020 American Transplant Congress
Non-Invasive Near Infrared Fluorescence Based Monitoring of Macrophage Mediated Inflammation
*Purpose: Clinical assessments for inflammation and acute rejection (AR) require regular, invasive biopsies followed by staining protocols that provide static images of tissue. Despite such…2020 American Transplant Congress
Donor-Derived Cell-Free DNA is Not Influenced by Steroid Dosing in Heart Transplant Recipients
*Purpose: Gene expression profiling (GEP) was recognized as an alternative to biopsy for rejection surveillance in the 2010 International society for Heart and Lung Transplantation…2020 American Transplant Congress
Two Pilot Studies Exploring the Diagnostic and Predictive Potential of Serum LAG3 and FGL1 in Kidney Transplant Recipients
*Purpose: Lymphocyte activation gene 3 (LAG3), an immune checkpoint, plays an important role in the negative regulation of immune response and the induction of immune…2020 American Transplant Congress
An Optimized Integrative Model Using Urinary Chemokines for Noninvasive Diagnosis of Acute Allograft Rejection
*Purpose: The aim of this study was to optimize the performance of urinary chemokines C-X-C motif ligand (CXCL) 9 and CXCL10 as noninvasive diagnostic markers…2020 American Transplant Congress
Noninvasive Detection of Subclinical Rejection in Urine RNA
*Purpose: Subclinical rejection may lead to long-term graft injury and can currently only be detected by repeated biopsies. A noninvasive method is needed to monitor…2020 American Transplant Congress
Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection
*Purpose: Monitoring kidney transplant rejection by repeated biopsies might result in increased procedural complications and cost. Exosomes are nanometer-sized vesicles released by cells carrying trans…2020 American Transplant Congress
Noninvasive Imaging of CD122+ T Cells via Immuno-PET for Detection of Acute Cellular Rejection
*Purpose: Acute cellular rejection (ACR) remains a clinically important problem following organ transplantation. Clinically, suspicion of ACR is dependent upon serum laboratory values, and diagnosis…
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