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American Transplant Congress abstracts

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Articles tagged "Lung transplantation"

  • 2016 American Transplant Congress

    Susceptibility Patterns of Pre-Transplant Pseudomonas and Post-Lung Transplant Outcomes in Patients with Cystic Fibrosis.

    S. Pouch,1 E. Lease,2 T. Bogdanovich,3 D. Ho,4 R. Miller,5 M. Estabrook,6 T. Babu,7 C. Kotton,7 C. Shaver,8 L. Thomas,8 S. Aslam,9 T. McCarty,10 J. Garcia-Diaz,11 K. Doucette,12 S. Kirkby,13 D. van Duin.14

    1Ohio State University, Columbus, OH; 2University of Washington, Seattle, WA; 3University of Pittsburgh, Pittsburgh, PA; 4Stanford University, Stanford, CA; 5University of Iowa, Iowa City, IA; 6Washington University St. Louis, St. Louis, MO; 7Massachusetts General Hospital, Boston, MA; 8Vanderbilt University, Nashville, TN; 9University of California San Diego, San Diego, CA; 10University of Alabama, Birmingham, AB; 11Ochsner Clinic Foundation, New Orleans, LA; 12University of Alberta, Edmonton, AB, Canada; 13Nationwide Children's Hospital, Columbus, OH; 14University of North Carolina, Chapel Hill, NC.

    Background: The impact of pre-lung transplant (LT) pan-drug-resistant Pseudomonas aeruginosa (PDR PsA) colonization on post-LT mortality and bronchiolitis obliterans syndrome (BOS) rates in cystic fibrosis…
  • 2016 American Transplant Congress

    The Apoptosis of the Tracheal Epithelia Increase the Recipient's MSCs Derived Myofibroblasts in Allografts to Exacerbate Obliterative Bronchiolitis After Tracheal Transplantation in Mice.

    C. Wang,1 T. Xia,1 X. Zhang,2 K. Jiang,1 J. Wang,1 J. Nie.1

    1Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuahn, Hubei, China; 2Department of Integrative Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuahn, Hubei, China.

    Background: The long-term outcome of lung transplantation is impeded by obliterative bronchiolitis (OB). However, the current treatment cannot effectively prevent the process of OB. The…
  • 2016 American Transplant Congress

    Achieving Timely Therapeutic Mycophenolic Acid Levels in Pediatric Lung Transplant Patients.

    C. Kam, S. Kim, E. Melicoff.

    Texas Children's Hospital, Houston, TX.

    The purpose of this study was to determine the appropriate initial dose of mycophenolate mofetil (MMF) in pediatric cystic fibrosis (CF) and non-CF lung transplant…
  • 2016 American Transplant Congress

    Are We Refusing Good Organs? Outcomes of Ventilator Management of Sub-Optimal Lung Donors.

    B. Scully,1 D. Horne,1 J. Heinle,1 E. McKenzie,1 K. Hosek,2 W. Zhang,2 G. Mallory,3 E. Melicoff.3

    1Congenital Heart Surgery, Texas Children's Hospital, Houston, TX; 2Outcomes and Impact Services, Texas Children's Hospital, Houston, TX; 3Pulmonology, Texas Children's Hospital, Houston, TX.

    PurposeOptimizing donor lung function is essential for organ acceptance and successful lung transplantation (LTx). We hypothesized that ventilator management of sub-optimal donor lungs, PaO2<300 mmHg,…
  • 2016 American Transplant Congress

    Outcomes in Lung Transplant Patients Requiring Extracorporeal Membrane Oxygenation (ECMO) in the Perioperative Period.

    A. Habertheuer, M. Williams, S. Miller, E. Cantu, C. Bermudez, P. Vallabhajosyula.

    Cardiovascular Surger, Hospital of the University of Pennsylvania, Philadelphia, PA.

    Objective As ECMO therapy is increasingly used to bridge high-risk patients with end-stage respiratory failure to lung transplantation, outcomes of this strategy employed in the…
  • 2016 American Transplant Congress

    Abrogating Donor-Derived Myd88 Signaling Impairs the Recruitment of Recipient Neutrophils and CD8 T Cells into Lung Allografts in Mice.

    Z. Zheng,1 J.-J. Wang,1 X. Yeap,1 X. Kang,1 Y. Xie,1 X. Luo,2 Z. Zhang.1

    1Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; 2Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.

    Objectives: Transplant ischemia reperfusion injury (IRI) mediated primary graft dysfunction (PGD) remains the predominant cause of short- and long-term graft loss in lung transplantation. This…
  • 2016 American Transplant Congress

    Hospitalizations, Survival, and Complications: 1-Year Outcomes for Elderly Lung Transplant Recipients.

    N. Casciello, A. Fuentes, J. Krisl, N. Sinha, T. Kaleekal.

    Houston Methodist Hospital, Houston, TX.

    Purpose: In 2014, The International Society for Heart and Lung Transplantation published consensus guidelines listing age greater than 65 years as a relative contraindication to…
  • 2016 American Transplant Congress

    BATF Deficiency in Tolerant Lung Allograft Recipients Are Resistant to Anti-MHC and Anti-Self-Antigen Mediated Pathogenesis of Obliterative Airway Disease.

    Z. Xu,1,2 X. Lin,1 M. Gunasekaran,1,2 M. Sharma,1,2 A. Gelman,1 T. Mohanakumar.1,2

    1Washington Univ Sch Med, St. Louis, MO; 2Norton Thoracic Institute - St. Joseph's Hospital, Phoenix, AZ.

    Antibodies (Abs) to donor MHC and lung self-antigens (SAgs) administered following induction of lung allograft tolerance by co-stimulation blockade can result in breaking of tolerance…
  • 2016 American Transplant Congress

    Comparison of Clinical Outcomes in Lung Transplant Patients with and without Preoperative Pulmonary Hypertension.

    A. Kalya, M. Boga, S. Dasyam, R. Walia, M. Smith, R. Bremner, A. Omar, V. Patel, E. Kuo, J. Huang, S. Hashimi.

    St. Joseph's Hospital and Medical Center, Phoenix.

    Purpose: End-stage lung disease patients (pts) who undergo lung transplantation (LTx) with an elevated mean pulmonary artery pressure (mPAP) are known to have adverse outcomes.…
  • 2016 American Transplant Congress

    Obliterative Bronchiolitis Following Lung Transplantation Is Preceded by Depletion of Airway Submucosal Glands and Basal Stem Cells.

    A. Swatek, A. Crooke, P. Anderson, T. Lynch, M. Ivanovic, J. Klesney-Tait, M. Eberlein, T. Pena, J. Engelhardt, K. Parekh.

    University of Iowa, Iowa City, IA.

    Background: Obliterative bronchiolitis (OB), a major cause of morbidity and mortality following lung transplantation, is characterized by progressive fibrosis of distal airways. We hypothesized that…
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