2015 American Transplant Congress
Donor Microbiota and Its Contribution for the Development of Primary Graft Dysfunction Following Human Lung Transplantation
Background: The microbiome of the donor lung will be imported to the recipient, and its role in allograft immunity remains speculative. The aims of this…2015 American Transplant Congress
Donor Lung Preservation With the Organ Care System® Promotes a Tissue Protective and Anti-Inflammatory Response During Transplantation
ObjectivesWithin INSPIRE trial standard cold storage (SOC) is compared to normothermic, ventilated donor lung preservation (Organ-Care-System®, OCS). As lung preservation may influence immune mediators (IM),…2015 American Transplant Congress
Respiratory Infections Following Lung Transplantation Leads to De Novo Development of Antibodies to Both Donor HLA and Lung Associated Self-Antigens and Increases the Risk for Bronchiolitis Obliterans Syndrome
Background: It is accepted that lower respiratory tract infections (LRI) post lung transplantation (LTx) are a risk factor for the development of Bronchiolitis Obliterans Syndrome…2015 American Transplant Congress
Ex Vivo Lung Perfusion: Revisit to the Optimal Oxygenation Circulating Lungs for Graft Preservation
Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
AimAccumulating evidence supports increasing the role of ex vivo lung perfusion (EVLP). However, there are evidenced limitations as well as the adverse effects of current…2015 American Transplant Congress
The Impact of Alemtuzumab and Basiliximab Induction On Patient and Graft Survival in Single Lung Transplant Recipients
PurposeTo evaluate the impact of alemtuzumab, basiliximab and no induction therapy on patient survival and chronic rejection.Methods3242 adult single lung transplantation from 2006 to 2013…2015 American Transplant Congress
Cross-Linking of MHC Class I Induces Unique Transcriptional Profiles Associated With Regulation of Both T and B Cells That Precedes Induction of Allo- and Auto-Immunity Leading to Obliterative Airway Disease
Surgery, Washington Univ Sch of Med, St. Louis, MO.
Background: Incidences of chronic rejection, bronchiolitis obliterans syndrome (BOS), remain a major challenge to lung transplantation and development of allo- and auto-immunity has been proposed…2015 American Transplant Congress
Lung Transplant Patients With Elevated Baseline Pulmonary Arterial Pressures Are More Likely to Recover from Post-Transplant Acute Kidney Injury
Purpose: Elevated pre-operative pulmonary arterial pressures predict acute kidney injury (AKI) after lung transplant. It is unknown if the elevated pulmonary pressures predict recovery from…2015 American Transplant Congress
Do CMS Oversight and the Systems Improvement Agreement Really Change Institutional Behavior?
Center for Transplantation and Organ Failure, University of kentucky, Lexington, KY.
In 2010 the pulmonary transplant program at the University of Kentucky entered a Systems Improvement Agreement (SIA) with CMS as a consequence of poor performance…2015 American Transplant Congress
Acute Kidney Injury After Lung Transplantation – Incidence, Risk Factors and Mechanisms
Background: Acute kidney injury (AKI) is a frequent and severe complication after solid organ transplantation. In a retrospective analysis and afterwards in a prospective clinical…2015 American Transplant Congress
Lung Transplantation from Donors With Kidney Disease
Duke University Medical Center, Durham, NC.
Background:Various donor characteristics are associated with decreased survival following single (SLT) or bilateral (BLT) lung transplantation. No current studies exist regarding use of lungs from…
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