ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Lung transplantation"

  • 2020 American Transplant Congress

    Circulatory Extracellular Vesicles from Lung Allograft Recipients with Chronic Lung Allograft Dysfunction Can Induce LKB1 Dependent Epithelial-Mesenchymal Transition

    M. Rahman, S. Angara, A. Arjuna, M. Smith, R. Bremner, T. Mohanakumar

    Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ

    *Purpose: Extracellular vesicles (EVs) play important role in physiological and pathological conditions. Recently we demonstrated that circulating exosomes (EVs) with lung self-antigens (SAgs) play important…
  • 2020 American Transplant Congress

    Improved Platelet Sequestration with Humanization of Von Willebrand Factor in Pig Xenogeneic Lung Perfusion Model

    M. R. Connolly1, L. Burdorf1, Z. Abady1, S. Sendil2, E. Redding2, B. Cerel1, S. Pratts1, C. Phelps3, W. Eyestone3, D. Ayares3, A. Azimzadeh1, R. N. Pierson III1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2University of Maryland, Baltimore, Baltimore, MD, 3Revivicor, Blacksburg, VA

    *Purpose: Von Willebrand factor (vWF) is an important element of hemostasis and when activated, mediates platelet adhesion and promotes platelet aggregation under shear stress conditions.…
  • 2020 American Transplant Congress

    A Large Animal Model of Ex-Vivo Lung Perfusion as a Platform to Deliver Therapeutic Agents to Lungs Before Lung Transplant

    T. M. Egan1, B. Haithcock1, M. H. Ali1, J. W. Blackwell1, B. Masuodi1, S. Shipley2, T. Long3, A. Akerman1, S. Montgomery4, H. Yuan5, P. Stewart6, J. Potenziano7, C. Sekaran7, R. Fitch7

    1Surgery, UNC at Chapel Hill, Chapel Hill, NC, 2Department of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, 3Pathology and Laboratory Medicine,, UNC at Chapel Hill, Chapel Hill, NC, 4Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, 5Radiology, UNC at Chapel Hill, Chapel Hill, NC, 6Gillings Global School of Public Health, UNC at Chapel Hill, Chapel Hill, NC, 7Mallinckrodt Pharmaceuticals, Hazelwood, MO

    *Purpose: Ex-vivo lung perfusion (EVLP) has been used to evaluate lung function before lung transplant (LT). We used EVLP to expose lungs recovered 6 hours…
  • 2020 American Transplant Congress

    What’s Lung Got to Do with It?: The Impact of the 2017 Lung Allocation Policy at a Single Organ Procurement Organization

    A. J. Boyer, J. B. Nave, C. A. Hostetler, C. C. Muse, R. A. Squires, J. P. Orlowski

    LifeShare Transplant Donor Services of Oklahoma, Oklahoma City, OK

    *Purpose: To describe the impact of the lung allocation change on a single organ procurement organization (OPO). The allocation change took place on 11/24/2017 and…
  • 2020 American Transplant Congress

    Incidence and Influencing Factors of Venous Thromboembolism after Lung Transplantation

    L. Fan1, J. Chen2, B. Wu1, Z. Zhai3

    1Pulmonary and Critical Care Medicine, Wuxi People’s Hospital, Wuxi, China, 2Thoracic Surgery, Wuxi People’s Hospital, Wuxi, China, 3Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China

    *Purpose: To analyze the incidence and influencing factors of venous thromboembolism (VTE) after lung transplantation.*Methods: This study retrospectively analyzed the clinical data of 375 lung…
  • 2020 American Transplant Congress

    Application of Image-Guidance Using 2D Illustrations and 3D Modeling of Donor Anatomy During Living Donor Hepatectomy

    M. Lim, S. Kim, K. Kim, O. Lee, J. Kwon, E. Jeong, J. Yang, G. Choi

    Transplantation, Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: For living donor liver transplantation, preoperative imaging is required for the safety of donor and recipient. As we started our image-guidance program using 2D…
  • 2020 American Transplant Congress

    High Frequencies of Donor-Derived Memory T and NK Cells in the Blood of Lung Transplant Recipients May Contribute to Protection from Chronic Lung Allograft Dysfunction

    R. Bellmàs Sanz1, A. Hitz1, B. Wiegmann2, K. Bläsing1, F. Ius2, W. Sommer2, J. Kühne1, L. Horn1, A. Knöfel2, I. Tudorache2, A. Haverich2, D. Jonigk3, G. Warnecke2, C. Falk1

    1Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, 2Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany, 3Institute of Pathology, Hannover Medical School MHH, Hannover, Germany

    *Purpose: After lung transplantation (LuTx), a transient chimerism of donor cells exists in the blood of recipients due to the migration of lymphocytes from the…
  • 2020 American Transplant Congress

    Proteomic Profiling of Circulating Extracellular Vesicles Isolated from Human Lung Transplant Recipients

    S. Bansal1, M. McGilvrey2, K. Garcia-Mansfield2, R. Sharma2, R. Bremner1, M. Smith1, R. Hachem3, P. Pirrotte2, T. Mohanakumar1

    1Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, 2Translational Genomics Research Institute (TGen), Collaborative Center for Translational Mass Spectrometry (CCTMS), Phoenix, AZ, 3Department of Medicine, Washington University School of Medicine, Phoenix, AZ

    *Purpose: Circulating exosomes in human lung transplant recipients (LTxRs) with acute (AR) and chronic rejection (bronchiolitis obliterans syndrome [BOS]) contain donor human leukocyte antigen (HLA)…
  • 2020 American Transplant Congress

    Late Onset Primary Graft Dysfunction after Lung Transplantation Correlates with Transplant Arteriosclerosis in a Humanized Mouse Model

    M. Franz1, T. Siemeni1, A. Knöfel1, W. Sommer1, M. Avsar1, F. Ius1, I. Tudorache1, C. Kühn1, C. S. Falk2, G. Warnecke1, A. Haverich1

    1Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, 2IFB-Tx, Hannover Medical School, Hannover, Germany

    *Purpose: Primary Graft dysfunction (PGD) is one of the most important causes of early mortality after lung transplantation. We investigated the correlation between the incidence…
  • 2020 American Transplant Congress

    Dosing and Outcomes of Conversion to Extended-Release Tacrolimus in Heart and Lung Transplant Recipients

    C. Doligalski1, K. Walter1, P. Chang2, L. J. Lobo2

    1University of North Carolina Medical Center, Chapel Hill, NC, 2Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC

    *Purpose: Extended release tacrolimus (LCP-Tac) is a novel once daily formulation with improved pharmacokinetic parameters compared to immediate release tacrolimus (IR-Tac). LCP-Tac use in renal…
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