Susceptibility Patterns of Pre-Transplant Pseudomonas and Post-Lung Transplant Outcomes in Patients with Cystic Fibrosis.

S. Pouch,¹ E. Lease,² T. Bogdanovich,³ D. Ho,⁴ R. Miller,⁵ M. Estabrook,⁶ T. Babu,⁷ C. Kotton,⁷ C. Shaver,⁸ L. Thomas,⁸ S. Aslam,⁹ T. McCarty,¹⁰ J. Garcia-Diaz,¹¹ K. Doucette,¹² S. Kirkby,¹³ D. van Duin.¹⁴

¹Ohio State University, Columbus, OH
²University of Washington, Seattle, WA
³University of Pittsburgh, Pittsburgh, PA
⁴Stanford University, Stanford, CA
⁵University of Iowa, Iowa City, IA
⁶Washington University St. Louis, St. Louis, MO
⁷Massachusetts General Hospital, Boston, MA
⁸Vanderbilt University, Nashville, TN
⁹University of California San Diego, San Diego, CA
¹⁰University of Alabama, Birmingham, AB
¹¹Ochsner Clinic Foundation, New Orleans, LA
¹²University of Alberta, Edmonton, AB, Canada
¹³Nationwide Children's Hospital, Columbus, OH
¹⁴University of North Carolina, Chapel Hill, NC.

Meeting: 2016 American Transplant Congress

Abstract number: B283

Keywords: Lung infection, Lung transplantation, Mortality, Rejection

Topic:

Session Information

Session Name: Poster Session B: Lung Transplantation Posters

Date: Sunday, June 12, 2016

Session Time: 6:00pm-7:00pm

Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Background: The impact of pre-lung transplant (LT) pan-drug-resistant Pseudomonas aeruginosa (PDR PsA) colonization on post-LT mortality and bronchiolitis obliterans syndrome (BOS) rates in cystic fibrosis (CF) LT recipients (LTR) is unknown.

Methods: Retrospective, multicenter study from 1/1/2010 to 12/31/2011 of CF LTR with PsA airway colonization within 6 months of LT with 3 years of follow-up post-LT.

Results: 14 centers enrolled 99 LTR (median lung allocation score 40 [IQR 37-51]). 52/99 (53%) LTR had pre-LT PDR PsA. LTR with PDR PsA were older (median age 29 [IQR 25-36] vs 24 years [IQR 19-29], p<0.01), received more peri-LT antibiotics (median 4 [IQR 3-5] vs 3 [IQR 3-4], p<0.01), were more likely to receive induction therapy (88% vs 70%, p=0.02), and had a longer post-LT length of stay (LOS, mean 29 vs 19 days, p<0.05). Rates of BOS (19% vs 36%, [p=0.07]), 3-year mortality (17% vs 30%, [p=0.16]) and time from LT to BOS or death were similar among LTR with vs without PDR PsA.

Conclusions: While PDR PsA colonization is associated with longer post-LT LOS in CF LTR, rates of post-LT BOS and mortality were similar in patients with PDR vs other PsA.

CITATION INFORMATION: Pouch S, Lease E, Bogdanovich T, Ho D, Miller R, Estabrook M, Babu T, Kotton C, Shaver C, Thomas L, Aslam S, McCarty T, Garcia-Diaz J, Doucette K, Kirkby S, van Duin D. Susceptibility Patterns of Pre-Transplant Pseudomonas and Post-Lung Transplant Outcomes in Patients with Cystic Fibrosis. Am J Transplant. 2016;16 (suppl 3).

To cite this abstract in AMA style:

Pouch S, Lease E, Bogdanovich T, Ho D, Miller R, Estabrook M, Babu T, Kotton C, Shaver C, Thomas L, Aslam S, McCarty T, Garcia-Diaz J, Doucette K, Kirkby S, Duin Dvan. Susceptibility Patterns of Pre-Transplant Pseudomonas and Post-Lung Transplant Outcomes in Patients with Cystic Fibrosis. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/susceptibility-patterns-of-pre-transplant-pseudomonas-and-post-lung-transplant-outcomes-in-patients-with-cystic-fibrosis/. Accessed May 17, 2021.

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