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American Transplant Congress abstracts

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Articles tagged "HLA antibodies"

  • 2015 American Transplant Congress

    Number of Antigen Targets: A Key Parameter for Accurate Flow Cytometry Crossmatch Interpretation of Weak DSA

    L. Hidalgo,1 S. Hasenbank,1 A. Halpin,1 P. Campbell.1,2

    1Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; 2Medicine, University of Alberta, Edmonton, AB, Canada.

    BACKGROUND: Flow cytometry crossmatch (FCXM) results are used to assess the safety of a transplant across pre-existing DSA. The number of targets on donor cells…
  • 2015 American Transplant Congress

    Improving the Predictive Value of the Virtual Crossmatch: Is the C1Q Assay Needed?

    A. Colovai,1 C. Savchik,1 P. Masiakos,1 S. Calp-Inal,2 L. Kayler,3 E. Akalin.2

    1Transplant Immunology Laboratory, Montefiore Medical Center, Bronx, NY; 2Nephrology, Montefiore Medical Center, Bronx, NY; 3Surgery, Montefiore Medical Center, Bronx, NY.

    The criteria for reporting unacceptable HLA antigens of renal transplant candidates differ greatly between transplant centers. In the attempt to refine these criteria, the experience…
  • 2015 American Transplant Congress

    Outcome of Bortezomib/Plasmapheresis for the Sensitized Patient Awaiting Heart Transplant

    J. Patel, N. Reinsmoen, M. Kittleson, D. Dilibero, F. Liou, D. Chang, M. Hamilton, L. Czer, F. Esmailian, J. Kobashigawa.

    Cedars-Sinai Heart Institute, Los Angeles, CA.

    Purpose: Allosensitization of patients (pts) awaiting heart transplantation is a significant challenge as it prolongs the time to transplant, increases wait-list mortality and increases risk…
  • 2015 American Transplant Congress

    Bortezomib Treatment in Antibody Mediated Rejection After Kidney Transplantation

    J. Lee,1 J. Lee,1 B. Kim,2 Y. Park,3 M. Ju,1 M. Kim,1 S. Kim,1 Y. Kim,1 K. Huh.1

    1Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; 2Department of Internal Medicine, Yonsei University Health System, Seoul, Republic of Korea; 3Department of Laboratory Medicine, Yonsei University Health System, Seoul, Republic of Korea.

    BackgroundSeveral studies demonstrated bortezomib therapy for antibody-mediated rejection (AMR) in renal transplants. However, the treatment efficacy according to target antigen or occurrence time of AMR…
  • 2015 American Transplant Congress

    Are DQA Antibodies Real?

    J. Jones, D. Lucas, M. Leffell, A. Zachary.

    Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

    Antibodies specific for HLA-DQ antigens appear to be increasing in frequency in the post-transplant period and are difficult to reduce effectively with desensitization protocols using…
  • 2015 American Transplant Congress

    Extended Analysis of Tocilizumab (anti-IL-6R) + Intravenous Immunoglobulin (IVIG) as Desensitization (DES) Agents for Reduction of Donor Specific Antibodies (DSA) in Patients Resistant to DES With IVIG + Rituximab

    A. Vo, J. Choi, I. Kim, J. Kahwaji, A. Peng, R. Villicana, S. Jordan.

    Kidney Transplant, Cedars-Sinai Medical Center, Los Angeles, CA.

    Introduction: IVIG+rituximab is an acceptable approach for DES with good outcomes. Despite this, ∼30% of patients fail DES, thus other approaches are needed. Options include…
  • 2015 American Transplant Congress

    Incidence of De Novo Donor Specific Antibodies in Kidney Transplant Recipients

    C. Staino, N. Pilch, O. Moussa, K. Boyle, J. Casale, K. Covert, J. Fleming, D. Taber, H. Meadows, C. Mardis, K. Chavin, S. Nadig, J. McGillicuddy, C. Bratton, T. Srinivas, P. Baliga.

    MUSC, Charleston, SC.

    The reported incidence and risk factors for the development of de novo donor specific antibodies (dnDSA) are variable. Although dnDSA is a negative predictor of…
  • 2015 American Transplant Congress

    Differences in Reactivity of HLA-Specific Antibodies May Be Explained By Differences in Their Affinities for Selected Epitopes on HLA Proteins

    S. Daga,1,2 D. Lowe,6 R. Buchli,5 J. Collard,5 A. Mulder,8 C. McMurtrey,4,5 H. Moyse,7 N. Evans,7 N. Krishnan,2 W. Hildebrand,4,5 F. Claas,8 D. Briggs,3 D. Zehnder,1,2 D. Mitchell,1 R. Higgins.1,2

    1Clinical Sciences Research Laboratories, University of Warwick, Coventry, United Kingdom; 2Renal Unit, University Hospital, Coventry and Warwickshire NHS Trust, Coventry, United Kingdom; 3Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Birmingham, United Kingdom; 4University of Oklahoma Health Science Center, Oklahoma City; 5Pure Protein LLC, Oklahoma City; 6Department of Histocompatibility and Immunogenetics, Royal Liverpool University Hospital, Liverpool, United Kingdom; 7School of Engineering, University of Warwick, Coventry, United Kingdom; 8Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.

    Affinity of IgG immunoglobulins for antigen varies and matures within the evolution of immune responses. Affinity is likely to be different for different epitope-antibody interactions…
  • 2015 American Transplant Congress

    Impact of Pretransplant Pregnancy On Immunization and Immunologic Outcome in Kidney Transplantation

    O. Staeck,1 D. Khadzhynov,1 S. Kreimer,1 E. Rajakangas,1 C. Schönemann,2 N. Lachmann,2 K. Budde,1 F. Halleck.1

    1Nephrology, Charité Universitätsmedizin, Berlin, Germany; 2Zentrum für Transfusionsmedizin, Charité Universitätsmedizin, Berlin, Germany.

    BACKGROUND:The detailed impact of pretransplant pregnancy on HLA alloimmunization and outcome after kidney transplantation is so far not well known.PATIENTS AND METHODS:A retrospective single center…
  • 2015 American Transplant Congress

    Pre-Transplant Donor Specific Antibody With Negative Flow-Crossmatch Was Related to Higher Acute Rejection But Not to Poor Graft Survival

    A. Guichard-Romero, L. Marino-Vazquez, M. Lopez, N. Castelan, A. De-Santiago, N. Uribe-Uribe, J. Alberu, L. Morales-Buenrostro.

    Nephrology, Transplantation, and Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

    Background: DSA have been associated to lower graft survival and a higher humoral rejection rate, but there is a concern about the clinical impact of…
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