2015 American Transplant Congress
Impact of Positive Crossmatch Due to Non-HLA Antibodies on Graft Outcomes in Renal Transplantation
Houston Methodist Hospital, Houston, TX.
It is widely recognized that a positive allogeneic crossmatch (+alloXM) due to pre-existing human leukocyte antigen (HLA) antibodies is associated with early rejection episodes. However,…2015 American Transplant Congress
Extended Analysis of Tocilizumab (anti-IL-6R) + Intravenous Immunoglobulin (IVIG) as Desensitization (DES) Agents for Reduction of Donor Specific Antibodies (DSA) in Patients Resistant to DES With IVIG + Rituximab
Kidney Transplant, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: IVIG+rituximab is an acceptable approach for DES with good outcomes. Despite this, ∼30% of patients fail DES, thus other approaches are needed. Options include…2015 American Transplant Congress
Clinical Outcome of Patients With De Novo C1q Binding Donor-Specific HLA Antibodies After Renal Transplantation
A. Not all de novo donor-specific HLA antibodies (dnDSA) are causing immediate graft loss. The importance of complement-binding DSA was recently shown with a commercial…2015 American Transplant Congress
Evaluation of Preformed Anti-HLA Antibody of "Unknown Origin" after Kidney Transplant in a Brazilian Center
Background: The use of single antigen beads assay (SAFB) for the detection of anti-HLA antibodies (Abs) may reveal the presence of Abs in individuals without…2015 American Transplant Congress
The Correlation Between Donor Specific Antibodies and Heart Transplant Rejection
The presence of donor specific HLA antibodies (DSA) has been shown to be detrimental to heart transplant (HTx) survival. Virtual crossmatching (VXM) offers a rapid…2015 American Transplant Congress
Pre-Transplant Donor Specific Antibody With Negative Flow-Crossmatch Was Related to Higher Acute Rejection But Not to Poor Graft Survival
Background: DSA have been associated to lower graft survival and a higher humoral rejection rate, but there is a concern about the clinical impact of…2015 American Transplant Congress
Early Antibody Mediated Rejection in HLA Antibody Incompatible Kidney Transplantation – A Treatable Condition Without Heavy Induction Immunosuppression
Transplantation across preformed donor specific HLA antibodies (DSA) not only carries a risk of early acute antibody mediated rejection (AMR) and graft loss, but also…2015 American Transplant Congress
Does Switching Predict Conversion: IgM De Novo Donor Specific HLA Antibodies Class Switch to IgG in Subclinical Antibody Mediated Rejection in Heart Transplant Recipients
1Cleveland Clinic, Cleveland; 2School of Medicine, Leipzig University, Leipzig, Germany.
Background: Concomitant C4d and C3d detection in heart biopsies correlates with circulating DSA and graft dysfunction. Detection of C4d only in surveillance biopsies is not…2015 American Transplant Congress
Improved Long-Term Graft Survival in Renal Transplant Recipients With Donor Specific Antibodies (DSA) After Mycophenolic Acid Escalation
Background: DSA formation in post-renal transplant patients is associated with chronic rejection and graft failure. Previous studies in our population indicate DSA formation is a…2015 American Transplant Congress
A Distinct Glomerular Complement Deposition Pattern in Transplant Glomerulopathy
University of Minnesota, Minneapolis.
While many patients with transplant glomerulopathy (TG) have donor-specific antibodies, the lack of C4d deposition in the peritubular capillaries (ptc-C4d) in some cases has caused…
American Transplant Congress abstracts