ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "HLA antibodies"

  • 2015 American Transplant Congress

    Impact of Positive Crossmatch Due to Non-HLA Antibodies on Graft Outcomes in Renal Transplantation

    S. Kuten, S. Patel, G. Land, T. Eagar, R. Knight, J. Loucks, L. Gaber, A. Gaber.

    Houston Methodist Hospital, Houston, TX.

    It is widely recognized that a positive allogeneic crossmatch (+alloXM) due to pre-existing human leukocyte antigen (HLA) antibodies is associated with early rejection episodes. However,…
  • 2015 American Transplant Congress

    Extended Analysis of Tocilizumab (anti-IL-6R) + Intravenous Immunoglobulin (IVIG) as Desensitization (DES) Agents for Reduction of Donor Specific Antibodies (DSA) in Patients Resistant to DES With IVIG + Rituximab

    A. Vo, J. Choi, I. Kim, J. Kahwaji, A. Peng, R. Villicana, S. Jordan.

    Kidney Transplant, Cedars-Sinai Medical Center, Los Angeles, CA.

    Introduction: IVIG+rituximab is an acceptable approach for DES with good outcomes. Despite this, ∼30% of patients fail DES, thus other approaches are needed. Options include…
  • 2015 American Transplant Congress

    Clinical Outcome of Patients With De Novo C1q Binding Donor-Specific HLA Antibodies After Renal Transplantation

    J. Bamoulid,1 A. Roodenburg,2 O. Staeck,1 C. Schoenemann,2 N. Lachmann,2 K. Budde.1

    1Nephrology, Charite Hospital-University of Medicine, Berlin, Germany; 2HLA Laboratory, Charite Hospital-University of Medicine, Berlin, Germany.

    A. Not all de novo donor-specific HLA antibodies (dnDSA) are causing immediate graft loss. The importance of complement-binding DSA was recently shown with a commercial…
  • 2015 American Transplant Congress

    Evaluation of Preformed Anti-HLA Antibody of "Unknown Origin" after Kidney Transplant in a Brazilian Center

    D. Glasberg,1 D. Monteiro de Carvalho,2 T. Matuck,2 G. Fabricio-Silva,3 M. Barbosa,1 A. Borela,1 L. Christiani,1 R. Malta,1 L. Porto.3

    1Nephrology, Bonsucesso Federal Hospital, Rio de Janeiro, Brazil; 2Transplant Service, São Francisco de Assis Hospital, Rio de Janeiro, Brazil; 3Histocompatibility and Cryopreservation Laboratory, State University of Rio de Janeiro, Rio de Janeiro, Brazil.

    Background: The use of single antigen beads assay (SAFB) for the detection of anti-HLA antibodies (Abs) may reveal the presence of Abs in individuals without…
  • 2015 American Transplant Congress

    The Correlation Between Donor Specific Antibodies and Heart Transplant Rejection

    R. Bedard,1 P. Jindra,2 M. Manson,1 M. Moaddab,1 H. Mallidi,3 W. Etheridge,1 A. Civitello,3 R. Kerman.2

    1CHI St. Luke's Health - Baylor St. Luke's Medical Center, Houston, TX; 2Immune Evaluation Laboratory, Baylor College of Medicine, Houston, TX; 3Texas Heart Institute, Baylor College of Medicine, Houston, TX.

    The presence of donor specific HLA antibodies (DSA) has been shown to be detrimental to heart transplant (HTx) survival. Virtual crossmatching (VXM) offers a rapid…
  • 2015 American Transplant Congress

    Pre-Transplant Donor Specific Antibody With Negative Flow-Crossmatch Was Related to Higher Acute Rejection But Not to Poor Graft Survival

    A. Guichard-Romero, L. Marino-Vazquez, M. Lopez, N. Castelan, A. De-Santiago, N. Uribe-Uribe, J. Alberu, L. Morales-Buenrostro.

    Nephrology, Transplantation, and Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

    Background: DSA have been associated to lower graft survival and a higher humoral rejection rate, but there is a concern about the clinical impact of…
  • 2015 American Transplant Congress

    Early Antibody Mediated Rejection in HLA Antibody Incompatible Kidney Transplantation – A Treatable Condition Without Heavy Induction Immunosuppression

    S. Daga,1,2 N. Krishnan,1 D. Lowe,3 F. Lam,1 C. Imray,1,2 H. Kashi,1 L. Tan,1 D. Briggs,3 R. Higgins.1,2

    1Renal Department, University Hospital, Coventry, United Kingdom; 2Warwick Medical School, University of Warwick, Coventry, United Kingdom; 3H&I Department, NHSBT, Birmingham, United Kingdom.

    Transplantation across preformed donor specific HLA antibodies (DSA) not only carries a risk of early acute antibody mediated rejection (AMR) and graft loss, but also…
  • 2015 American Transplant Congress

    Does Switching Predict Conversion: IgM De Novo Donor Specific HLA Antibodies Class Switch to IgG in Subclinical Antibody Mediated Rejection in Heart Transplant Recipients

    M. Askar,1 R. Rodriguez,1 L. Klingman,1 D. Thomas,1 A. Zhang,1 H. Morf,2 N. Hamon,1 N. Moazami,1 E. Hsich,1 D. Taylor,1 R. Starling,1 C. Tan.1

    1Cleveland Clinic, Cleveland; 2School of Medicine, Leipzig University, Leipzig, Germany.

    Background: Concomitant C4d and C3d detection in heart biopsies correlates with circulating DSA and graft dysfunction. Detection of C4d only in surveillance biopsies is not…
  • 2015 American Transplant Congress

    Improved Long-Term Graft Survival in Renal Transplant Recipients With Donor Specific Antibodies (DSA) After Mycophenolic Acid Escalation

    L. Rebellato,1 K. Parker,2 F. Rana,3 S. Kendrick,4 C. Morgan,5 C. Haisch,5 M. Everly,6 R. Harland,5 P. Bolin.3

    1Pathology and Laboratory Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; 2Vidant Medical Center, Greenville, NC; 3Internal Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; 4Eastern Nephrology Associates, Greenville, NC; 5Surgical Immunology and Transplantation, East Carolina University, Brody School of Medicine, Greenville, NC; 6Terasaki Foundation, Los Angeles, CA.

    Background: DSA formation in post-renal transplant patients is associated with chronic rejection and graft failure. Previous studies in our population indicate DSA formation is a…
  • 2015 American Transplant Congress

    A Distinct Glomerular Complement Deposition Pattern in Transplant Glomerulopathy

    P. Verghese, R. Reed, A. Matas, Y. Kim.

    University of Minnesota, Minneapolis.

    While many patients with transplant glomerulopathy (TG) have donor-specific antibodies, the lack of C4d deposition in the peritubular capillaries (ptc-C4d) in some cases has caused…
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