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Articles tagged "HLA antibodies"

  • 2015 American Transplant Congress

    A Specific Inhibitor of C1s, TNT003, Prevents Complement-Mediated Enhancement of Monocyte Adhesion to Endothelium in Response to HLA Antibodies

    N. Valenzuela,1 K. Thomas,1 A. Mulder,2 G. Parry,3 S. Parker,3 E. Reed.1

    1Immunogenetics Center, UCLA, Los Angeles, CA; 2Leiden University, Leiden, Netherlands; 3True North Therapeutics, San Francisco, CA.

    HLA antibody (Ab) mediated complement activation on endothelial cells (EC) is likely a critical driver of antibody-mediated inflammation. Production of complement anaphylatoxins by HLA antibodies…
  • 2015 American Transplant Congress

    Clinical Relevance of C3d-Binding Donor-Specific Antibodies in Late Kidney Allograft Failure

    J. Lan, D. Gjertson, Y. Zheng, DeKAF Investigators, E. Reed, M. Cecka.

    Path, UCLA, LA, CA.

    Background: The objective of this study was to investigate the prognostic value of C3d-binding donor-specific antibodies (DSA) in determining late kidney allograft failure.Methods: 1048 patients…
  • 2015 American Transplant Congress

    Repeat Donor HLA Mismatch Antigens and Kidney Transplant Outcome

    P. Lokhandwala,1 M. Wang,2 Z. Kadry,3 R. Shah,3 A. Jain,3 J. Gaspari,1 N. Ghahramani,4 C. Abendroth,1 H. Shike.1

    1Pathology, Penn State Hershey Medical Center, Hershey, PA; 2Public Health Sciences, Penn State College of Medicine, Hershey; 3Transplant Surgery, PSHMC, Hershey; 4Nephrology, PSHMC, Hershey.

    Background: Historically, poorer outcome has been reported in kidney re-transplant patients with repeat HLA mismatch antigens. Transplant practice has evolved. Risk of repeat mismatch antigen…
  • 2015 American Transplant Congress

    Clinical Significance of Estimated DSA MFI Values at 1,000 C1q MFI for Differentiation Between Harmful and Harmless DSA

    K. Horimi,1 T. Akaza,2 K. Kuroki,2 S. Sakamoto,2 Y. Matsuoka,1 Y. Watarai,2 S. Narumi,2 A. Katayama,3 K. Uchida,1 T. Kobayashi.4

    1Aichi Medical University, Nagkute, Japan; 2Nagoya Daini Red Cross Hospital, Nagoya, Japan; 3Masuko Memorial Hospital, Nagoya, Japan; 4Nagoya University School of Medicine, Nagoya, Japan.

    INTRODUCTIONControl of chronic antibody mediated rejection (CAMR) is essential for further improvement of long-term graft survival. Early detection of de novo donor specific antibodies (DSA)…
  • 2015 American Transplant Congress

    Impact of Positive Crossmatch Due to Non-HLA Antibodies on Graft Outcomes in Renal Transplantation

    S. Kuten, S. Patel, G. Land, T. Eagar, R. Knight, J. Loucks, L. Gaber, A. Gaber.

    Houston Methodist Hospital, Houston, TX.

    It is widely recognized that a positive allogeneic crossmatch (+alloXM) due to pre-existing human leukocyte antigen (HLA) antibodies is associated with early rejection episodes. However,…
  • 2015 American Transplant Congress

    Assessment of Circulating HLA-Specific Alloreactive Memory B Cells Reveals Surreptitious Immunized Kidney Transplant Recipients at High Risk of Antibody-Mediated Rejection

    M. Lúcia,1 S. Luque,1 E. Crespo,1 J. Cruzado,1,2 E. Melilli,2 J. Martorell,3 J. Torras,1,2 S. Gil-Vernet,2 J. Grinyo,1,2 O. Bestard.1,2

    1Renal transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Catalunya, Spain; 2Experimental Nephrology Laboratory, IDIBELL, Barcelona, Catalunya, Spain; 3Histocompatibility Unit, Immunology Department, Hospital Clinic, Barcelona, Catalunya, Spain.

    Even though current bead-based multiplex techniques enable an accurate assessment of circulating HLA-specific antibodies, a more comprehensive study of the humoral alloimmune response through the…
  • 2015 American Transplant Congress

    DQB1 Epitope Matching Predicts the Development of De Novo DSA and Antibody Mediated Rejection

    M. Willicombe,1 M. Blow,2 P. Brookes,2 E. Santos,2 D. Taube.1

    1Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London, United Kingdom; 2H&I, Hammersmith Hospital, London, United Kingdom.

    HLA DQ antibodies are the commonest de novo [DN] DSA specificity seen post renal transplantation. Their presence is associated with antibody mediated injury and allograft…
  • 2015 American Transplant Congress

    Measuring Affinity of Polyclonal HLA-Specific Antibodies in Highly Sensitised Cases Can Serve as an Additional Biomarker to Guide Direct Transplantation

    S. Daga,1,2 D. Lowe,6 R. Buchli,3 J. Collard,3 A. Mulder,8 C. McMurtrey,3,4 H. Moyse,7 N. Evans,7 N. Krishnan,2 W. Hildebrand,3,4 F. Claas,8 D. Briggs,5 D. Zehnder,1,2 D. Mithcell,1 R. Higgins.1,2

    1Clinical Sciences Research Laboratories, University of Warwick, Coventry, United Kingdom; 2Renal Unit, University Hospital, Coventry and Warwickshire NHS Trust, Coventry, United Kingdom; 3Pure Protein LLC, Oklahoma; 4University of Oklahoma Health Science Center, Oklahoma City; 5Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Birmingham, United Kingdom; 6Department of Histocompatibility and Immunogenetics, Royal Liverpool University Hospital, Liverpool, United Kingdom; 7School of Engineering, University of Warwick, Coventry, United Kingdom; 8Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.

    Significant numbers of patients on transplant waiting lists in the UK are sensitised (43%). Direct transplantation across these HLA-specific antibodies using risk stratification strategies are…
  • 2015 American Transplant Congress

    The Correlation Between Donor Specific Antibodies and Heart Transplant Rejection

    R. Bedard,1 P. Jindra,2 M. Manson,1 M. Moaddab,1 H. Mallidi,3 W. Etheridge,1 A. Civitello,3 R. Kerman.2

    1CHI St. Luke's Health - Baylor St. Luke's Medical Center, Houston, TX; 2Immune Evaluation Laboratory, Baylor College of Medicine, Houston, TX; 3Texas Heart Institute, Baylor College of Medicine, Houston, TX.

    The presence of donor specific HLA antibodies (DSA) has been shown to be detrimental to heart transplant (HTx) survival. Virtual crossmatching (VXM) offers a rapid…
  • 2015 American Transplant Congress

    Risk of HLA Antibody Sensitization in Pediatric Heart Failure Patients Pre/Post Berlin VAD Procedure and Pre/Post Heart Transplantation

    R. Kerman, P. Jindra, A. Jeewa, S. Burki, C. Fraser, I. Adachi.

    Baylor College of Medicine, Houston, TX; Texas Children's Hospital, Houston, TX.

    The Berlin Heart Excor Ventricular Assist Device (Berlin VAD) was designed for use in children with heart failure. The Berlin VAD has allowed for successful…
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