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Articles tagged "HLA antibodies"

  • 2015 American Transplant Congress

    Risk of HLA Antibody Sensitization in Pediatric Heart Failure Patients Pre/Post Berlin VAD Procedure and Pre/Post Heart Transplantation

    R. Kerman, P. Jindra, A. Jeewa, S. Burki, C. Fraser, I. Adachi.

    Baylor College of Medicine, Houston, TX; Texas Children's Hospital, Houston, TX.

    The Berlin Heart Excor Ventricular Assist Device (Berlin VAD) was designed for use in children with heart failure. The Berlin VAD has allowed for successful…
  • 2015 American Transplant Congress

    Post Transplant De Novo Donor Specific Antibodies Correlate With the Development of Bronchiolitis Obliterans Syndrome Following Pediatric Lung Transplantation

    E. Melicoff, J. Maddox, M. Ebenbichler, J. Heinle, D. McKenzie, P. Jindra, G. Mallory, R. Kerman.

    Texas Children's Hospital, Houston, TX; Baylor College of Medicine, Houston, TX.

    HLA donor specific antibodies (DSA) have been associated with poor allograft survival following adult solid organ transplantation (Tx). However, there is little evidence implicating post-Tx…
  • 2015 American Transplant Congress

    De Novo Donor-Specific HLA Antibodies After Kidney Transplantation Are Associated With Donation After Circulatory Death and HLA-DQ Mismatch

    G. Dreyer,1 D. Roelen,2 S. Brand-Schaaf,2 O. Dekkers,3 M. Reinders,1 F. Claas,2 J. de Fijter.1

    1Nephrologie, LUMC, Leiden, Netherlands; 2Immunohaematology and Blood Transfusion, LUMC, Leiden, Netherlands; 3Clinical Epidemiology, Aarhus Medical Center, Aarhus C, Denmark.

    Introduction: De novo donor-specific HLA-antibodies (dnDSA) have been associated with rejection and inferior kidney graft survival. The purpose of this study was to investigate the…
  • 2015 American Transplant Congress

    Both Preformed and De Novo Cw Donor Specific Antibodies Are Clinically Significant in Renal Transplantation

    A. Gueret-Wardle, M. Willicombe, V. Dibbur, P. Brookes, A. McLean, D. Taube.

    Imperial College Kidney and Transplant Centre, Imperial College NHS, London, United Kingdom.

    Preformed [PF] and de novo [DN] anti-HLA A, B, DR and DQ donor specific antibodies [DSAbs] are associated with poorer allograft outcomes secondary to antibody…
  • 2015 American Transplant Congress

    Antibodies Directed Against HLA-DQ Are Significantly Associated to Complement Activation In Vitro

    J. Arreola-Guerra, A. de Santiago, A. Arvizu, N. Gonzalez-Tableros, M. Lopez, M. Vilatoba, L. Morales-Buenrostro, J. Alberu, N. Castelan.

    1Transplantation, 1aNephrology-Mineral Metabolism, Inst Nal de Ciencias Medicas y Nutricion SZ, Mexico City, Distrito Federal, Mexico.

    Background: C1q-binding HLA antibodies (HLAabs) have been related to acute rejection and long-term graft loss. The characteristics of these antibodies and factors associated to complement…
  • 2015 American Transplant Congress

    Prediction of Acute Antibody Mediated Rejection in Antibody Incompatible Renal Transplantation Using Machine Learning for Wide Data

    T. Shaikhina,1 N. Khovanova,1 S. Daga,1,3 N. Krishnan,2 D. Lowe,3 D. Mitchell,1 D. Briggs,2 R. Higgins.3

    1University of Warwick, Coventry, United Kingdom; 2NHS Blood and Transplant, Birmingham, United Kingdom; 3University Hospitals Coventry and Warwickshire, Coventry, United Kingdom.

    The dynamic field of renal transplantation is characterised by limited access to data, the high cost of equipment and underlying complexity of immunological responses to…
  • 2015 American Transplant Congress

    Bortezomib Treatment in Antibody Mediated Rejection After Kidney Transplantation

    J. Lee,1 J. Lee,1 B. Kim,2 Y. Park,3 M. Ju,1 M. Kim,1 S. Kim,1 Y. Kim,1 K. Huh.1

    1Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; 2Department of Internal Medicine, Yonsei University Health System, Seoul, Republic of Korea; 3Department of Laboratory Medicine, Yonsei University Health System, Seoul, Republic of Korea.

    BackgroundSeveral studies demonstrated bortezomib therapy for antibody-mediated rejection (AMR) in renal transplants. However, the treatment efficacy according to target antigen or occurrence time of AMR…
  • 2015 American Transplant Congress

    Desensitization Protocol Including Concomitant Bortezomib and Rituximab Did Not Reduce Calculated PRA Nor Mean MFI Values Among Waitlisted Patients for Deceased Donor Kidney Transplantation

    S. Kang,1 H. Lim,1 J. Jeong,1 E. Song,2 I. Yun,3 C. Ahn,1 J. Yang.1

    1Transplantation Center, Seoul National University Hospital, Seoul, Korea; 2Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea; 3Department of Surgery, Konkuk University, Seoul, Korea.

    Highly sensitized (HS) patients (pts) seldom have chance to receive deceased donor kidney transplant (DDKT). A desensitization (DES) program including bortezomib was employed to facilitate…
  • 2015 American Transplant Congress

    Intermittent High Dose Intravenous Immunoglobulin as Treatment for Donor Specific Antibodies in Renal Transplant Recipients

    P. Bolin,1 K. Parker,2 F. Rana,1 W. Bryant,1 P. Jawa,1 R. Harland.3

    1Internal Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; 2Vidant Medical Center, Greenville, NC; 3Surgical Immunology and Transplantation, East Carolina University, Brody School of Medicine, Greenville, NC.

    Background: Donor-specific HLA antibody (DSA) formation in post-renal transplant patients is associated with chronic rejection and graft failure. Previous studies in our population have indicated…
  • 2015 American Transplant Congress

    Immunoglobulin G Donor-Specific Anti-HLA Antibody Subclasses and Kidney Allograft Antibody-Mediated Injury

    D. Viglietti,1,2 C. Bentlejewski,3 J.-P. Duong van Huyen,4,2 D. Vernerey,5,2 O. Aubert,2 J. Verine,1 X. Jouven,2 C. Legendre,4 D. Glotz,1 A. Loupy,2,4 A. Zeevi,3 C. Lefaucheur.1,2

    1Saint-Louis Hospital, Paris, France; 2Paris Translational Research Center for Organ Transplantation - INSERM U970, Paris, France; 3University of Pittsburgh Medical Center, Pittsburgh; 4Necker Hospital, Paris, France; 5CHRU de Besançon, Besançon, France.

    Experimental and clinical data suggest that antibodies have different pathogenicities according to their IgG subclasses. We investigated the association between IgG subclasses of circulating anti-HLA…
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