ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "HLA antibodies"

  • 2020 American Transplant Congress

    CD56DimCD16Bright NK Cells from Kidney Transplant Recipients with Antibody-Mediated Rejection Display Increased Proliferation, Self-Renewal, Pro-Inflammatory and Cytotoxic Profile

    E. A. Bailly1, K. Louis1, C. Macedo1, B. Ramaswami1, M. Lucas1, A. Zeevi1, C. Lefaucheur2, D. Metes1

    1Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, 2INSERM UMR-S976. Endothelium, Inflammation & Alloreactivity, Université de Paris, France

    *Purpose: Contribution of NK cells to antibody-mediated rejection (ABMR) injuries have recently been highlighted through transcriptomic analysis and immunohistochemistry of kidney and heart allograft biopsies.…
  • 2020 American Transplant Congress

    The Impact of DSA Screening in Stable Kidney Transplant Recipients in the 1st Year Post-Transplant

    A. Sharma1, D. Jorgensen2, R. Mehta1, P. Sood1, C. Wu1, C. M. Puttarajappa1, A. Tevar1, S. Hariharan1

    1Thomas E. Starzl Transplant Institute, Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA, 2Thomas E. Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: The importance of Donor Specific Antibody (DSA) as a screening tool within the 1st year post kidney transplant in stable patients remains unclear. We…
  • 2020 American Transplant Congress

    Donor-Specific B Cell Frequency Assessed by a Novel Multiplex Bead-Based Assay Predicts Graft Failure in Kidney Transplant Recipients

    Z. Ilyas, A. Akl, D. Pinelli, L. Gallon, A. R. Tambur, M. Ansari

    Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: Kidney transplant recipients with sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) or Donor-specific anti-HLA antibodies (DSA) are at…
  • 2020 American Transplant Congress

    Desensitization Combining Costimulation Blockade with Proteasome Inhibition in Highly Sensitized Transplant Candidates

    S. Restaino1, D. Jennings2, G. Serban3, E. Vasilescu3, G. Sayer1, N. Uriel1, K. Takeda4, Y. Naka4, M. Farr1, M. V. Habal1

    1Cardiology, Columbia University Irving Medical Center, New York, NY, 2School of Nursing, Columbia University Irving Medical Center, New York, NY, 3Pathology&Cell Biology, Columbia University Irving Medical Center, New York, NY, 4Cardiothoracic Surgery, Columbia University Irving Medical Center, New York, NY

    *Purpose: Antibodies to human leukocyte antigens (HLA) pose a significant barrier to transplantation. Strategies to reduce allosensitization have modest efficacy and may result in antibody…
  • 2020 American Transplant Congress

    A Single-Center Analysis of Using Allele-Level 11 HLA Loci Information on cPRA and Organ-Allocation Points in Kidney Transplant Candidates

    C. Maguire1, P. Muluhngwi1, E. Kransdorf2, L. Gragert3, A. R. Tambur1

    1Northwestern University, Chicago, IL, 2Cedars-Sinai Heart Institute, Beverly Hills, CA, 3Tulane University, New Orleans, LA

    *Purpose: Calculated panel reactive antibodies (cPRA) is used by the United Network for Organ Sharing (UNOS) to quantify degree of HLA sensitization and assign priority…
  • 2020 American Transplant Congress

    The Association between Alloimmunity and De Novo Glomerulonephritis Post Kidney Transplantation

    P. Khairallah, J. Kamal, E. Vasilescu, I. Batal, G. Dube

    Columbia University Medical Center, New York, NY

    *Purpose: In contrast to recurrent immune complex-mediated glomerulonephritis (ICGN), de novo ICGN of the allograft is poorly characterized. We hypothesize that alloimmunity results in immune-complex…
  • 2020 American Transplant Congress

    The Role of Galectin-1 and Basement Membrane Remodeling in Kidney Antibody-Mediated Rejection

    S. Clotet-Freixas1, C. McEvoy1, I. Batruch2, M. Kotlyar3, C. Pastrello3, J. Van1, M. Arambewela1, A. Boshart1, S. Farkona1, A. Bozovic4, V. Kulasingam4, P. Chen1, I. Jurisica3, A. Chruscinski1, R. John4, A. Konvalinka5

    1Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 2Department of Laboratory Medicine and Pathobiology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, 3Krembil Research Institute, University Health Network, Toronto, ON, Canada, 4Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, 5Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada

    *Purpose: Antibody-mediated rejection (AMR), the leading cause of kidney graft loss, is caused by anti-HLA and non-HLA antibodies against proteins in two main kidney compartments:…
  • 2020 American Transplant Congress

    The Ratio between Naïve and Memory B Cells is Associated with Development of Early Donor-Specific Antibodies within the First Month after Lung Transplantation

    A. Hitz1, R. Bellmàs Sanz1, F. Ius2, J. Kühne1, B. Wiegmann2, W. Sommer2, J. Salman2, T. Siemeni2, C. Kühn2, M. Avsar2, A. Haverich2, I. Tudorache2, G. Warnecke2, C. Falk1

    1Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, 2Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany

    *Purpose: After lung transplantation (LuTx), the development of early donor HLA-specific antibodies (eDSA) has been shown to be associated with antibody-mediated rejection (AMR) and poor…
  • 2020 American Transplant Congress

    The Liver Protects All? Donor Specific Antibody Formation in Heart-Liver Transplant Recipients

    A. W. Rogers1, T. N. Eagar2, C. Pham1, J. Krisl1, B. J. Pierce1, M. Moaddab1, R. Ghobrial3, B. Trachtenberg4, A. Bhimaraj4, A. O. Gaber3

    1Department of Pharmacy, Houston Methodist Hospital, Houston, TX, 2Department of Pathology, Houston Methodist Hospital, Houston, TX, 3Department of Surgery, Houston Methodist Hospital, Houston, TX, 4Houston Methodist Hospital, Houston, TX

    *Purpose: Donor specific antibodies (DSAs) are key in the development of antibody mediated rejection (AMR). Their role in decreased patient and graft survival has been…
  • 2020 American Transplant Congress

    Single Dose Rituximab and Anti-Thymocyte Globulin (ATG) Induction in Hypersensitized Kidney Transplant Recipients

    A. X. Wang, U. Wang, S. Busque, C. R. Lenihan

    Stanford University School of Medicine, Stanford, CA

    *Purpose: Hypersensitized kidney transplant recipients (calculated panel reactive antibody (cPRA) ≥98%) may represent a population at high risk of posttransplant immunologic events. While access to…
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