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Articles tagged "HLA antibodies"

  • 2015 American Transplant Congress

    CPRA Values Are Substantially Increased for Some Candidates Subsequent to Inclusion of Unacceptable C-locus (UA-C) Antigens While Listing Practices Remain Unchanged

    A. Kucheryavaya,1 R. Bray,2 A. Miller,1 D. Tyan.3

    1UNOS, Richmond; 2Emory University Hospital, Atlanta; 3Stanford University, Palo Alto.

    Background: CPRA is the % of deceased donors expected to have one or more UAs with a given candidate. Prior to 12/5/13, candidates with UA-C…
  • 2015 American Transplant Congress

    Immunoglobulin G Donor-Specific Anti-HLA Antibody Subclasses and Kidney Allograft Antibody-Mediated Injury

    D. Viglietti,1,2 C. Bentlejewski,3 J.-P. Duong van Huyen,4,2 D. Vernerey,5,2 O. Aubert,2 J. Verine,1 X. Jouven,2 C. Legendre,4 D. Glotz,1 A. Loupy,2,4 A. Zeevi,3 C. Lefaucheur.1,2

    1Saint-Louis Hospital, Paris, France; 2Paris Translational Research Center for Organ Transplantation - INSERM U970, Paris, France; 3University of Pittsburgh Medical Center, Pittsburgh; 4Necker Hospital, Paris, France; 5CHRU de Besançon, Besançon, France.

    Experimental and clinical data suggest that antibodies have different pathogenicities according to their IgG subclasses. We investigated the association between IgG subclasses of circulating anti-HLA…
  • 2015 American Transplant Congress

    De Novo Donor-Specific HLA Antibodies After Kidney Transplantation Are Associated With Donation After Circulatory Death and HLA-DQ Mismatch

    G. Dreyer,1 D. Roelen,2 S. Brand-Schaaf,2 O. Dekkers,3 M. Reinders,1 F. Claas,2 J. de Fijter.1

    1Nephrologie, LUMC, Leiden, Netherlands; 2Immunohaematology and Blood Transfusion, LUMC, Leiden, Netherlands; 3Clinical Epidemiology, Aarhus Medical Center, Aarhus C, Denmark.

    Introduction: De novo donor-specific HLA-antibodies (dnDSA) have been associated with rejection and inferior kidney graft survival. The purpose of this study was to investigate the…
  • 2015 American Transplant Congress

    C1q Reactivity and IgG Subtypes After HLA Antibody Removal Therapy With Carfilzomib in Thoracic Transplant Recipients

    A. Zeevi, M. Marrari, C. Bentlejewski, J. Pilewski, M. Morrell, J. McDyer, M. Shullo, J. Teuteberg, C. Bermudez, C. Ensor.

    Univ of Pittsburgh, Pittsburgh.

    Conventional therapies for antibody removal consisting of plasma exchange with IVIG and Rituximab are partially effective in desensitization protocols and for treatment of antibody mediated…
  • 2015 American Transplant Congress

    A Specific Inhibitor of C1s, TNT003, Prevents Complement-Mediated Enhancement of Monocyte Adhesion to Endothelium in Response to HLA Antibodies

    N. Valenzuela,1 K. Thomas,1 A. Mulder,2 G. Parry,3 S. Parker,3 E. Reed.1

    1Immunogenetics Center, UCLA, Los Angeles, CA; 2Leiden University, Leiden, Netherlands; 3True North Therapeutics, San Francisco, CA.

    HLA antibody (Ab) mediated complement activation on endothelial cells (EC) is likely a critical driver of antibody-mediated inflammation. Production of complement anaphylatoxins by HLA antibodies…
  • 2015 American Transplant Congress

    Clinical Relevance of C3d-Binding Donor-Specific Antibodies in Late Kidney Allograft Failure

    J. Lan, D. Gjertson, Y. Zheng, DeKAF Investigators, E. Reed, M. Cecka.

    Path, UCLA, LA, CA.

    Background: The objective of this study was to investigate the prognostic value of C3d-binding donor-specific antibodies (DSA) in determining late kidney allograft failure.Methods: 1048 patients…
  • 2015 American Transplant Congress

    Repeat Donor HLA Mismatch Antigens and Kidney Transplant Outcome

    P. Lokhandwala,1 M. Wang,2 Z. Kadry,3 R. Shah,3 A. Jain,3 J. Gaspari,1 N. Ghahramani,4 C. Abendroth,1 H. Shike.1

    1Pathology, Penn State Hershey Medical Center, Hershey, PA; 2Public Health Sciences, Penn State College of Medicine, Hershey; 3Transplant Surgery, PSHMC, Hershey; 4Nephrology, PSHMC, Hershey.

    Background: Historically, poorer outcome has been reported in kidney re-transplant patients with repeat HLA mismatch antigens. Transplant practice has evolved. Risk of repeat mismatch antigen…
  • 2015 American Transplant Congress

    Clinical Significance of Estimated DSA MFI Values at 1,000 C1q MFI for Differentiation Between Harmful and Harmless DSA

    K. Horimi,1 T. Akaza,2 K. Kuroki,2 S. Sakamoto,2 Y. Matsuoka,1 Y. Watarai,2 S. Narumi,2 A. Katayama,3 K. Uchida,1 T. Kobayashi.4

    1Aichi Medical University, Nagkute, Japan; 2Nagoya Daini Red Cross Hospital, Nagoya, Japan; 3Masuko Memorial Hospital, Nagoya, Japan; 4Nagoya University School of Medicine, Nagoya, Japan.

    INTRODUCTIONControl of chronic antibody mediated rejection (CAMR) is essential for further improvement of long-term graft survival. Early detection of de novo donor specific antibodies (DSA)…
  • 2015 American Transplant Congress

    Impact of Positive Crossmatch Due to Non-HLA Antibodies on Graft Outcomes in Renal Transplantation

    S. Kuten, S. Patel, G. Land, T. Eagar, R. Knight, J. Loucks, L. Gaber, A. Gaber.

    Houston Methodist Hospital, Houston, TX.

    It is widely recognized that a positive allogeneic crossmatch (+alloXM) due to pre-existing human leukocyte antigen (HLA) antibodies is associated with early rejection episodes. However,…
  • 2015 American Transplant Congress

    Assessment of Circulating HLA-Specific Alloreactive Memory B Cells Reveals Surreptitious Immunized Kidney Transplant Recipients at High Risk of Antibody-Mediated Rejection

    M. Lúcia,1 S. Luque,1 E. Crespo,1 J. Cruzado,1,2 E. Melilli,2 J. Martorell,3 J. Torras,1,2 S. Gil-Vernet,2 J. Grinyo,1,2 O. Bestard.1,2

    1Renal transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Catalunya, Spain; 2Experimental Nephrology Laboratory, IDIBELL, Barcelona, Catalunya, Spain; 3Histocompatibility Unit, Immunology Department, Hospital Clinic, Barcelona, Catalunya, Spain.

    Even though current bead-based multiplex techniques enable an accurate assessment of circulating HLA-specific antibodies, a more comprehensive study of the humoral alloimmune response through the…
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