2016 American Transplant Congress
Donor-Specific Antibodies in a Single-Center Pediatric Kidney Transplant Population – Incidence and Risk Factors.
In mid-2015, we implemented donor-specific antibody (DSA) monitoring in our pediatric kidney transplant recipient (pKTR) population as recommended (Transplantation 2013;95:19-). We now cross-sectionally analyzed our…2016 American Transplant Congress
Posttransplant AT1Rabs Precede De Novo HLA-DSA Development.
Angiotensin II type 1 receptor antibodies (AT1Rabs) have been associated with acute allograft rejection and graft loss. The possible implication of the generation of de…2016 American Transplant Congress
Anti-HLA Antibodies in Allogeneic and Autologous Hematopoietic Stem Cell Transplantation.
Introduction: Anti-HLA antibodies have been associated with graft rejection in solid organ and hematopoietic stem cell transplantation (HSCT). The aim of this study was describe…2016 American Transplant Congress
Antibody Mediated Rejection and Mixed Acute Rejection: Long Term Results and Predictive Factors for Graft Loss Following Proteasome Inhibitor Therapy.
1U of Cincinnati, Cincinnati; 2The Christ Hospital, Cincinnati.
Purpose: Proteasome inhibitor (PI) therapy has been increasingly used to treated antibody mediated rejection (AMR) and mixed acute rejection (MAR). The purpose of this study…2016 American Transplant Congress
Analysis of Intra-Graft Anti-HLA Antibodies Suggests That HLA Sensitization Occurs Long After an Allograft Nephrectomy and Is Not Due to a Release of Anti-HLA Antibodies from the Failed Kidney.
Background: The mechanism leading to the appearance of anti-HLA antibodies and donor-specific antibodies (DSAs) after an allograft nephrectomy (NTx) is not fully understood. Two mechanisms…2016 American Transplant Congress
Factors Predicting Risk for Antibody-Mediated Rejection in Highly Sensitized Pediatric Renal Transplants.
Introduction: Antibody-mediated rejection (ABMR) is a concern in highly sensitized (HS) patients (pts) receiving renal transplant (tx). We have previously published that a donor specific…2016 American Transplant Congress
Enhanced Natural Killer Responsiveness Is a Potent Cytotoxic Mechanism Associating to Kidney Allograft Dysfunction and Pathogenic Effects of Donor-Specific Antibodies (DSA).
While antibody mediated rejection (ABMR) is a major cause of kidney transplant loss, the role of Natural Killer cells (NK) as immune effectors of complement-independent…2016 American Transplant Congress
Kidney Graft Homing of De Novo Donor Specific HLA Antibodies Is an Early Step within the Antibody-Mediated Graft Damage Process.
In this study, by a parallel analysis on sera and graft biopsies we have analyzed, in a pediatric cohort of unsensitized recipients of a first…2016 American Transplant Congress
DSA After Transplant Increases Risk of Renal Allograft Failure Independent of Concurrent Biopsy Results: The DEKAF Study Data.
Donor-specific HLA antibodies (DSA) are a major cause of renal allograft dysfunction and loss following transplant. The presence of DSA, with or without C4d deposition,…2016 American Transplant Congress
Should HLA DR and DQ Eplet Mismatching Replace Traditional DR and DQ Mismatching for Deceased Donor Offers in Pediatric Renal Transplantation?
Introduction. It is now appreciated that greater HLA DR mismatching of the first pediatric kidney transplantation is associated with higher degrees of sensitization, lower rates…
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