Articles tagged "Bone marrow transplantation"

2020 American Transplant Congress
Hematopoietic Cell Transplantation and Solid Organ Transplantation: Outcomes of Sequential Transplantation in the United States
M. Gupta¹, M. Levine², D. Porter², R. Brazauskas³, S. Bo-Subait⁴, R. Phelan³, M. Battiwalla⁵, D. Buchbinder⁶, B. Hamilton⁷, B. Shaw³, P. Abt²
¹University of Kentucky, Lexington, KY, ²University of Pennsylvania, Philadelphia, PA, ³Medical College of Wisconsin, Milwaukee, WI, ⁴CIBMTR, NMDP, Minneapolis, MN, ⁵Sarah Cannon Blood Cancer Network, Nashville, TN, ⁶Children's Hospital of Orange County, Orange, CA, ⁷Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH
*Purpose: Survival after solid organ transplantation(SOT) and hematopoietic cell transplantation(HCT) has steadily risen. Despite these improvements, SOT recipients may develop conditions requiring HCT, and HCT…
2020 American Transplant Congress
Induction of Delayed Immune Tolerance after Reconstructive Transplantation by Combining Donor Bone Marrow Transplantation and High-Dose Cyclophosphamide Treatment
Y. Guo¹, F. Messner¹, B. Oh¹, G. Furtmüller¹, W. Lee¹, D. Cooney¹, L. Luznik², G. Brandacher¹
¹Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Immunosuppression avoidance by induction of immune tolerance represents a primary goal in the field of transplantation. Yet, success of this concept relies on extensive…
2020 American Transplant Congress
Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
J. Leventhal¹, J. Mathew¹, J. Galvin², L. Gallon¹, D. Belshe¹, K. Ravindra³, M. Horwitz³, J. Miller¹, S. Ildstad⁴
¹Northwestern, Chicago, IL, ²UIC, Chicago, IL, ³Duke, Durham, NC, ⁴U Louisville, Louisville, KY
*Purpose: 37 pts have been transplanted since 2009 in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts (KTx). The…
2020 American Transplant Congress
Orthogonal IL-2 Cytokine-Receptor Pair Capable of Selective Expansion of Regulatory T Cells Facilitates Alloengraftment
T. Hirai¹, F. Simonetta², L. L. Su³, L. Picton³, J. Baker², J. Lin⁴, P. Li⁴, W. J. Leonard⁴, K. C. Garcia³, R. S. Negrin²
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA, ³Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University, Stanford, CA, ⁴Laboratory of Molecular Immunology, National Institutes of Health, Bethesda, MD
*Purpose: Adoptive transfer of regulatory T cells (Tregs) has been shown to improve alloengraftment in animal models. However, ex vivo Treg expansion for the purpose…
2020 American Transplant Congress
Hepatitis B Virus Prophylaxis and Treatment among Hematopoietic Stem Cell Transplant Recipients: Impact on Engraftment and Outcomes
B. Buzo¹, J. Fernandes Ramos², R. Marques Rossetti³, N. Salles⁴, A. Mendrone-Junior⁴, V. Rocha³, A. de Seixas Santos Nastri⁵
¹Division of Infectious Diseases, University of Alberta, Edmonton, AB, Canada, ²Division of Infectious Diseases and Division of Hematology, University of Sao Paulo, Sao Paulo, Brazil, ³Division of Hematology, University of Sao Paulo, Sao Paulo, Brazil, ⁴Fundacao Pro-Sangue, Sao Paulo, Brazil, ⁵Division of Infectious Diseases, University of Sao Paulo, Sao Paulo, Brazil
*Purpose: Hepatitis B virus infection is a worldwide concern with a broad distribution. It can reactivate in immunocompromised populations such as solid organ and hematopoietic…
2019 American Transplant Congress
Expansion of Regulatory T and B Cells in Swine Rendered Tolerant of Allogeneic Vascularized Composite Allografts via Mixed Chimerism
G. Saviane¹, A. Lellouch¹, A. Andrews¹, L. Lantieri², M. Randolph¹, G. Benichou¹, C. Cetrulo Jr¹
¹Center for Transplantation Sciences, Division of Plastic Surgery, Boston, MA, USA, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA, ²European Georges Pompidou Hospital, University of Paris, Department of Plastic Surgery, Paris, France
*Purpose: Prevention of acute rejection of vascularized composite allografts (VCAs) requires ongoing systemic immunosuppression, which subject patients to infectious, metabolic, reno-vascular and neoplastic complications. It…
2019 American Transplant Congress
Ten Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
J. Leventhal¹, J. Galvin¹, L. Gallon¹, D. Stare¹, K. Ravindra², M. Horwitz², M. Abecassis¹, S. Ildstad³
¹Northwestern U, Chicago, IL, ²Duke U, Durham, NC, ³U Louisville, Louisville, KY
*Purpose: 37 subjects have been transplanted in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts (KTx) based upon tolerogenic…
2019 American Transplant Congress
After 10 Years: The Results of HLA Mismatched Combined Kidney and Bone Marrow Transplantation for Renal Allograft Tolerance
T. Kawai¹, D. H. Sachs¹, T. Spitzer¹, N. Tolkoff-Rubin¹, R. B. Colvin¹, N. Elias¹, M. Sykes², A. Cosimi¹
¹Massachusetts General Hospital, Boston, MA, ²Columbia University, NYC, NY
*Purpose: Based on decades-long basic studies in animal models, we have applied combined kidney and donor bone marrow transplantation (CKBMT) for induction of allograft tolerance…
2019 American Transplant Congress
Conceptual Extension of SNP Based Abundance Profiling to Infer Donor Derived Cell-Free DNA Fraction as an Indication of Organ Rejection
R. Sinha, K. Mickey, J. Grantham, M. Wissel, M. Altrich, S. Kleiboeker
R&D, Viracor-Eurofins, Lee's Summit, MO
*Purpose: Rejection is a major post-transplant complication for organ transplant recipients. Biopsy remains the standard to diagnose rejection, but other non-invasive methods, such as transcript…
2019 American Transplant Congress
JAK Inhibitor as a Novel Conditioning Approach to Establish Mixed Chimerism and Prevent Type 1 Diabetes Nonmyeloablatively
H. Xu¹, A. Merchak¹, J. Xu², Y. Huang¹, S. T. Ildstad¹
¹University of Louisville, Institute for Cellular Therapeutics, Louisville, KY, ²DuPont Manual High School, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of islet β cells. T1D has been found to be associated…