Articles tagged "Bone marrow transplantation"

2020 American Transplant Congress
ABH Subtype-Specific Tolerance after ABO-Mismatched Hematopoietic Cell Transplantation
B. Motyka¹, A. Halpin¹, J. Pearcey¹, A. Kariminia², A. Halevy², S. Maier¹, A. Halevy², P. Subrt², C. W. Cairo¹, G. D. Cuvelier³, K. R. Schultz², L. J. West¹
¹Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada, ²British Columbia Children’s Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada, ³CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada
*Purpose: ABO-mediated immunity is reported to have minimal detrimental impact after ABO-mismatched hematopoietic cell transplantation (HCT). Patients are generally presumed ‘tolerant’ with regard to ABO.…
2020 American Transplant Congress
Incidence of Non-Tuberculous Mycobacteria in the Transplant Population at a University Transplant Center in Northern Florida
D. Schain, Z. Breslow, G. El Helou, A. Cannella
Medicine/IDGM, Univ of Florida, College of Med, Gainesville, FL
*Purpose: Over the past decade, there has been an increase in the number of non-tuberculous mycobacteria (NTM) infections in the United States, especially in the…
2020 American Transplant Congress
Successful Use of Tedizolid for the Treatment of Nocardiosis in Transplant Recipients
R. Odrobina¹, B. Tritle², C. A.Gomez¹
¹Division of Infectious Diseases, University of Utah, Salt Lake City, UT, ²Department of Pharmacy, University of Utah, Salt Lake City, UT
*Purpose: Nocardiosis is an opportunistic infection occasionally seen after solid organ (SOT) and hematopoietic stem-cell transplantation. Treatment is challenging due to the limited number of…
2020 American Transplant Congress
Hematopoietic Cell Transplantation and Solid Organ Transplantation: Outcomes of Sequential Transplantation in the United States
M. Gupta¹, M. Levine², D. Porter², R. Brazauskas³, S. Bo-Subait⁴, R. Phelan³, M. Battiwalla⁵, D. Buchbinder⁶, B. Hamilton⁷, B. Shaw³, P. Abt²
¹University of Kentucky, Lexington, KY, ²University of Pennsylvania, Philadelphia, PA, ³Medical College of Wisconsin, Milwaukee, WI, ⁴CIBMTR, NMDP, Minneapolis, MN, ⁵Sarah Cannon Blood Cancer Network, Nashville, TN, ⁶Children's Hospital of Orange County, Orange, CA, ⁷Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH
*Purpose: Survival after solid organ transplantation(SOT) and hematopoietic cell transplantation(HCT) has steadily risen. Despite these improvements, SOT recipients may develop conditions requiring HCT, and HCT…
2020 American Transplant Congress
Induction of Delayed Immune Tolerance after Reconstructive Transplantation by Combining Donor Bone Marrow Transplantation and High-Dose Cyclophosphamide Treatment
Y. Guo¹, F. Messner¹, B. Oh¹, G. Furtmüller¹, W. Lee¹, D. Cooney¹, L. Luznik², G. Brandacher¹
¹Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Immunosuppression avoidance by induction of immune tolerance represents a primary goal in the field of transplantation. Yet, success of this concept relies on extensive…
2019 American Transplant Congress
JAK Inhibitor as a Novel Conditioning Approach to Establish Mixed Chimerism and Prevent Type 1 Diabetes Nonmyeloablatively
H. Xu¹, A. Merchak¹, J. Xu², Y. Huang¹, S. T. Ildstad¹
¹University of Louisville, Institute for Cellular Therapeutics, Louisville, KY, ²DuPont Manual High School, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of islet β cells. T1D has been found to be associated…
2019 American Transplant Congress
Galectin-3 Levels Are Associated with the Incidence and Severity of Chronic GVHD One Year after Allogeneic Hematopoietic Cell Transplantation
N. Navarro-Alvarez¹, A. R. Andrews¹, Z. DeFilipp², Y. A. Chen², V. T. Ho³, J. Ritz³, T. R. Spitzer⁴, C. A. Huang⁵
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, MA, ³Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA, ⁴Hematology/Oncology, Massachusetts General Hospital, Boston, MA, ⁵Plastic & Reconstructive Surgery and Transplant Surgery Divisions, University of Colorado, Denver, Aurora, CO
*Purpose: Chronic graft-versus-host disease (cGVHD) is a frequent complication of allogeneic hematopoietic cell transplantation (HCT) and a leading cause of late morbidity and mortality. T-…
2019 American Transplant Congress
Quality of Life in Tolerant Living Donor Kidney Transplants vs. Standard of Care
D. Tollerud¹, J. Leventhal², J. Galvin², J. Mathew², L. Gallon², D. Stare², J. Miller², M. Abecassis², S. Ildstad³
¹Regenerex, Inc., Louisville, KY, ²Northwestern U, Chicago, IL, ³U of Louisville, Louisville, KY
*Purpose: 37 subjects have been transplanted since 2009 in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts. The protocol…
2019 American Transplant Congress
Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice
Y. Huang, H. Xu, Y. Wen, S. Ildstad
University of Louisville, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…
2019 American Transplant Congress
Donor-Specific Tregs Prolong Peripheral Chimerism in Baboons Receiving GalTKO hCD47-tg Porcine Peripheral Blood Stem Cells
N. P. Llore¹, J. Stern¹, G. Pierre¹, E. Lopes¹, D. Ekanayake-Alper¹, P. Alonso-Guallart¹, K. Bruestle¹, H. Sakai¹, D. Ayares², M. Lorber², R. Hawley¹, D. H. Sachs¹, M. Sykes¹, A. D. Griesemer¹
¹Columbia Center for Translational Immunology, New York, NY, ²United Therapeutics, Silver Springs, MD
*Purpose: We have previously evaluated the ability of transplantation of polyclonal expanded recipient T regulatory cells to prolong xenogeneic chimerism and skin grafts after transplantation…