Articles tagged "Bone marrow transplantation"

2020 American Transplant Congress
Cardiac Allograft Tolerance Can be Achieved in Non-Human Primates via Transient Mixed Hematopoietic Chimerism and Erythropoietin Administration
K. Ahrens¹, J. M. O¹, W. Sommer², J. Morrissette¹, D. Becerra¹, P. M. Patel¹, A. Dehnadi¹, T. Costa¹, I. M. Hanekamp¹, J. S. Allan³, P. Cravedi⁴, P. S. Heeger⁴, G. Benichou¹, J. C. Madsen⁵
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ³Center for Transplantation Sciences, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, ⁴Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: In non-human primates (NHPs), a mixed chimerism-based conditioning protocol results in kidney transplant tolerance and combined kidney and heart allograft tolerance. Previous work showed…
2020 American Transplant Congress
Efficacy and Tolerability of Tedizolid Phosphate in the Treatment of Mycobacterium Abscessus Infection among Pediatric Hematopoietic Stem Cell Transplant Recipients
Y. Kang, V. M. Aquino, A. Y. Koh, D. Wetzel, P. K. Sue
Pediatrics, UT Southwestern Medical Center, Dallas, TX
*Purpose: Mycobacterium abscessus complex infections are associated with high rates of morbidity and mortality in immunocompromised hosts. Treatment can be challenging due to broad spectrum…
2020 American Transplant Congress
Kidney Transplantation after Multiple Myeloma: The Last 2 Decades
V. Nair, K. Jhaveri, M. Abate
Medicine, Northwell Health, Manhasset, NY
*Purpose: Due to recent advances, patients with a history of multiple myeloma (MM) and ESKD are more frequently offered kidney transplantation (Ktx). Existing literature does…
2020 American Transplant Congress
ABH Subtype-Specific Tolerance after ABO-Mismatched Hematopoietic Cell Transplantation
B. Motyka¹, A. Halpin¹, J. Pearcey¹, A. Kariminia², A. Halevy², S. Maier¹, A. Halevy², P. Subrt², C. W. Cairo¹, G. D. Cuvelier³, K. R. Schultz², L. J. West¹
¹Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada, ²British Columbia Children’s Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada, ³CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada
*Purpose: ABO-mediated immunity is reported to have minimal detrimental impact after ABO-mismatched hematopoietic cell transplantation (HCT). Patients are generally presumed ‘tolerant’ with regard to ABO.…
2020 American Transplant Congress
Incidence of Non-Tuberculous Mycobacteria in the Transplant Population at a University Transplant Center in Northern Florida
D. Schain, Z. Breslow, G. El Helou, A. Cannella
Medicine/IDGM, Univ of Florida, College of Med, Gainesville, FL
*Purpose: Over the past decade, there has been an increase in the number of non-tuberculous mycobacteria (NTM) infections in the United States, especially in the…
2020 American Transplant Congress
Successful Use of Tedizolid for the Treatment of Nocardiosis in Transplant Recipients
R. Odrobina¹, B. Tritle², C. A.Gomez¹
¹Division of Infectious Diseases, University of Utah, Salt Lake City, UT, ²Department of Pharmacy, University of Utah, Salt Lake City, UT
*Purpose: Nocardiosis is an opportunistic infection occasionally seen after solid organ (SOT) and hematopoietic stem-cell transplantation. Treatment is challenging due to the limited number of…
2020 American Transplant Congress
Hematopoietic Cell Transplantation and Solid Organ Transplantation: Outcomes of Sequential Transplantation in the United States
M. Gupta¹, M. Levine², D. Porter², R. Brazauskas³, S. Bo-Subait⁴, R. Phelan³, M. Battiwalla⁵, D. Buchbinder⁶, B. Hamilton⁷, B. Shaw³, P. Abt²
¹University of Kentucky, Lexington, KY, ²University of Pennsylvania, Philadelphia, PA, ³Medical College of Wisconsin, Milwaukee, WI, ⁴CIBMTR, NMDP, Minneapolis, MN, ⁵Sarah Cannon Blood Cancer Network, Nashville, TN, ⁶Children's Hospital of Orange County, Orange, CA, ⁷Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH
*Purpose: Survival after solid organ transplantation(SOT) and hematopoietic cell transplantation(HCT) has steadily risen. Despite these improvements, SOT recipients may develop conditions requiring HCT, and HCT…
2020 American Transplant Congress
Induction of Delayed Immune Tolerance after Reconstructive Transplantation by Combining Donor Bone Marrow Transplantation and High-Dose Cyclophosphamide Treatment
Y. Guo¹, F. Messner¹, B. Oh¹, G. Furtmüller¹, W. Lee¹, D. Cooney¹, L. Luznik², G. Brandacher¹
¹Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Immunosuppression avoidance by induction of immune tolerance represents a primary goal in the field of transplantation. Yet, success of this concept relies on extensive…
2020 American Transplant Congress
Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
J. Leventhal¹, J. Mathew¹, J. Galvin², L. Gallon¹, D. Belshe¹, K. Ravindra³, M. Horwitz³, J. Miller¹, S. Ildstad⁴
¹Northwestern, Chicago, IL, ²UIC, Chicago, IL, ³Duke, Durham, NC, ⁴U Louisville, Louisville, KY
*Purpose: 37 pts have been transplanted since 2009 in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts (KTx). The…
2020 American Transplant Congress
Orthogonal IL-2 Cytokine-Receptor Pair Capable of Selective Expansion of Regulatory T Cells Facilitates Alloengraftment
T. Hirai¹, F. Simonetta², L. L. Su³, L. Picton³, J. Baker², J. Lin⁴, P. Li⁴, W. J. Leonard⁴, K. C. Garcia³, R. S. Negrin²
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA, ³Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University, Stanford, CA, ⁴Laboratory of Molecular Immunology, National Institutes of Health, Bethesda, MD
*Purpose: Adoptive transfer of regulatory T cells (Tregs) has been shown to improve alloengraftment in animal models. However, ex vivo Treg expansion for the purpose…