2019 American Transplant Congress
Expansion of Regulatory T and B Cells in Swine Rendered Tolerant of Allogeneic Vascularized Composite Allografts via Mixed Chimerism
*Purpose: Prevention of acute rejection of vascularized composite allografts (VCAs) requires ongoing systemic immunosuppression, which subject patients to infectious, metabolic, reno-vascular and neoplastic complications. It…2019 American Transplant Congress
Ten Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
1Northwestern U, Chicago, IL, 2Duke U, Durham, NC, 3U Louisville, Louisville, KY
*Purpose: 37 subjects have been transplanted in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts (KTx) based upon tolerogenic…2019 American Transplant Congress
After 10 Years: The Results of HLA Mismatched Combined Kidney and Bone Marrow Transplantation for Renal Allograft Tolerance
1Massachusetts General Hospital, Boston, MA, 2Columbia University, NYC, NY
*Purpose: Based on decades-long basic studies in animal models, we have applied combined kidney and donor bone marrow transplantation (CKBMT) for induction of allograft tolerance…2019 American Transplant Congress
Conceptual Extension of SNP Based Abundance Profiling to Infer Donor Derived Cell-Free DNA Fraction as an Indication of Organ Rejection
R&D, Viracor-Eurofins, Lee's Summit, MO
*Purpose: Rejection is a major post-transplant complication for organ transplant recipients. Biopsy remains the standard to diagnose rejection, but other non-invasive methods, such as transcript…2019 American Transplant Congress
JAK Inhibitor as a Novel Conditioning Approach to Establish Mixed Chimerism and Prevent Type 1 Diabetes Nonmyeloablatively
*Purpose: Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of islet β cells. T1D has been found to be associated…2019 American Transplant Congress
Galectin-3 Levels Are Associated with the Incidence and Severity of Chronic GVHD One Year after Allogeneic Hematopoietic Cell Transplantation
*Purpose: Chronic graft-versus-host disease (cGVHD) is a frequent complication of allogeneic hematopoietic cell transplantation (HCT) and a leading cause of late morbidity and mortality. T-…2019 American Transplant Congress
Quality of Life in Tolerant Living Donor Kidney Transplants vs. Standard of Care
1Regenerex, Inc., Louisville, KY, 2Northwestern U, Chicago, IL, 3U of Louisville, Louisville, KY
*Purpose: 37 subjects have been transplanted since 2009 in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts. The protocol…2019 American Transplant Congress
Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice
University of Louisville, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…2019 American Transplant Congress
Donor-Specific Tregs Prolong Peripheral Chimerism in Baboons Receiving GalTKO hCD47-tg Porcine Peripheral Blood Stem Cells
*Purpose: We have previously evaluated the ability of transplantation of polyclonal expanded recipient T regulatory cells to prolong xenogeneic chimerism and skin grafts after transplantation…2018 American Transplant Congress
Low Intensity Conditioning Protocol for Inducing Chimerism-Based Tolerance in Non-Obese Diabetic Mice
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Type 1 diabetes is the most common chronic disease affecting children. Islet cell or pancreas transplantation offer the most physiologic approach to glucose homostasis. However…
American Transplant Congress abstracts