Articles tagged "Bone marrow transplantation"

2020 American Transplant Congress
Hepatitis B Virus Prophylaxis and Treatment among Hematopoietic Stem Cell Transplant Recipients: Impact on Engraftment and Outcomes
B. Buzo¹, J. Fernandes Ramos², R. Marques Rossetti³, N. Salles⁴, A. Mendrone-Junior⁴, V. Rocha³, A. de Seixas Santos Nastri⁵
¹Division of Infectious Diseases, University of Alberta, Edmonton, AB, Canada, ²Division of Infectious Diseases and Division of Hematology, University of Sao Paulo, Sao Paulo, Brazil, ³Division of Hematology, University of Sao Paulo, Sao Paulo, Brazil, ⁴Fundacao Pro-Sangue, Sao Paulo, Brazil, ⁵Division of Infectious Diseases, University of Sao Paulo, Sao Paulo, Brazil
*Purpose: Hepatitis B virus infection is a worldwide concern with a broad distribution. It can reactivate in immunocompromised populations such as solid organ and hematopoietic…
2020 American Transplant Congress
Cardiac Allograft Tolerance Can be Achieved in Non-Human Primates via Transient Mixed Hematopoietic Chimerism and Erythropoietin Administration
K. Ahrens¹, J. M. O¹, W. Sommer², J. Morrissette¹, D. Becerra¹, P. M. Patel¹, A. Dehnadi¹, T. Costa¹, I. M. Hanekamp¹, J. S. Allan³, P. Cravedi⁴, P. S. Heeger⁴, G. Benichou¹, J. C. Madsen⁵
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ³Center for Transplantation Sciences, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, ⁴Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: In non-human primates (NHPs), a mixed chimerism-based conditioning protocol results in kidney transplant tolerance and combined kidney and heart allograft tolerance. Previous work showed…
2020 American Transplant Congress
Efficacy and Tolerability of Tedizolid Phosphate in the Treatment of Mycobacterium Abscessus Infection among Pediatric Hematopoietic Stem Cell Transplant Recipients
Y. Kang, V. M. Aquino, A. Y. Koh, D. Wetzel, P. K. Sue
Pediatrics, UT Southwestern Medical Center, Dallas, TX
*Purpose: Mycobacterium abscessus complex infections are associated with high rates of morbidity and mortality in immunocompromised hosts. Treatment can be challenging due to broad spectrum…
2020 American Transplant Congress
Kidney Transplantation after Multiple Myeloma: The Last 2 Decades
V. Nair, K. Jhaveri, M. Abate
Medicine, Northwell Health, Manhasset, NY
*Purpose: Due to recent advances, patients with a history of multiple myeloma (MM) and ESKD are more frequently offered kidney transplantation (Ktx). Existing literature does…
2020 American Transplant Congress
ABH Subtype-Specific Tolerance after ABO-Mismatched Hematopoietic Cell Transplantation
B. Motyka¹, A. Halpin¹, J. Pearcey¹, A. Kariminia², A. Halevy², S. Maier¹, A. Halevy², P. Subrt², C. W. Cairo¹, G. D. Cuvelier³, K. R. Schultz², L. J. West¹
¹Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada, ²British Columbia Children’s Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada, ³CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada
*Purpose: ABO-mediated immunity is reported to have minimal detrimental impact after ABO-mismatched hematopoietic cell transplantation (HCT). Patients are generally presumed ‘tolerant’ with regard to ABO.…
2019 American Transplant Congress
Expansion of Regulatory T and B Cells in Swine Rendered Tolerant of Allogeneic Vascularized Composite Allografts via Mixed Chimerism
G. Saviane¹, A. Lellouch¹, A. Andrews¹, L. Lantieri², M. Randolph¹, G. Benichou¹, C. Cetrulo Jr¹
¹Center for Transplantation Sciences, Division of Plastic Surgery, Boston, MA, USA, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA, ²European Georges Pompidou Hospital, University of Paris, Department of Plastic Surgery, Paris, France
*Purpose: Prevention of acute rejection of vascularized composite allografts (VCAs) requires ongoing systemic immunosuppression, which subject patients to infectious, metabolic, reno-vascular and neoplastic complications. It…
2019 American Transplant Congress
Ten Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
J. Leventhal¹, J. Galvin¹, L. Gallon¹, D. Stare¹, K. Ravindra², M. Horwitz², M. Abecassis¹, S. Ildstad³
¹Northwestern U, Chicago, IL, ²Duke U, Durham, NC, ³U Louisville, Louisville, KY
*Purpose: 37 subjects have been transplanted in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts (KTx) based upon tolerogenic…
2019 American Transplant Congress
After 10 Years: The Results of HLA Mismatched Combined Kidney and Bone Marrow Transplantation for Renal Allograft Tolerance
T. Kawai¹, D. H. Sachs¹, T. Spitzer¹, N. Tolkoff-Rubin¹, R. B. Colvin¹, N. Elias¹, M. Sykes², A. Cosimi¹
¹Massachusetts General Hospital, Boston, MA, ²Columbia University, NYC, NY
*Purpose: Based on decades-long basic studies in animal models, we have applied combined kidney and donor bone marrow transplantation (CKBMT) for induction of allograft tolerance…
2019 American Transplant Congress
Conceptual Extension of SNP Based Abundance Profiling to Infer Donor Derived Cell-Free DNA Fraction as an Indication of Organ Rejection
R. Sinha, K. Mickey, J. Grantham, M. Wissel, M. Altrich, S. Kleiboeker
R&D, Viracor-Eurofins, Lee's Summit, MO
*Purpose: Rejection is a major post-transplant complication for organ transplant recipients. Biopsy remains the standard to diagnose rejection, but other non-invasive methods, such as transcript…
2019 American Transplant Congress
JAK Inhibitor as a Novel Conditioning Approach to Establish Mixed Chimerism and Prevent Type 1 Diabetes Nonmyeloablatively
H. Xu¹, A. Merchak¹, J. Xu², Y. Huang¹, S. T. Ildstad¹
¹University of Louisville, Institute for Cellular Therapeutics, Louisville, KY, ²DuPont Manual High School, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of islet β cells. T1D has been found to be associated…