ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

ABH Subtype-Specific Tolerance after ABO-Mismatched Hematopoietic Cell Transplantation

B. Motyka1, A. Halpin1, J. Pearcey1, A. Kariminia2, A. Halevy2, S. Maier1, A. Halevy2, P. Subrt2, C. W. Cairo1, G. D. Cuvelier3, K. R. Schultz2, L. J. West1

1Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada, 2British Columbia Children’s Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada, 3CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada

Meeting: 2020 American Transplant Congress

Abstract number: B-383

Keywords: Bone marrow transplantation, IgG, Infant, Pediatric

Session Information

Date: Saturday, May 30, 2020

Session Name: Poster Session B: Tolerance / Immune Deviation

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

Related Abstracts
  • Changes in Phenotype, Immune Suppressive, Function, and Gene Expression of Myeloid Derived Suppressor Cells in Patients Given Combined Kidney and Hematopoietic Cell Transplants in a Tolerance Protocol
  • Chimerism and Tolerance without GVHD in Mismatched Recipients of Combined Hematopoietic Stem Cell/Kidney Transplants: Donor-Specific Hyporeactivity Is Not a Reliable Biomarker for Tolerance

*Purpose: ABO-mediated immunity is reported to have minimal detrimental impact after ABO-mismatched hematopoietic cell transplantation (HCT). Patients are generally presumed ‘tolerant’ with regard to ABO. However, this has not been systematically evaluated, nor have ‘solid-phase’ assays been used for detection of ABO antibodies (Ab). A unique aspect post-HCT is immune reconstitution including delayed responses to polysaccharides, similar to normal infant development. We hypothesized that dynamics of immune reconstitution post-HCT mimics infant development, leading to ABO tolerance, and that ABO antibody solid-phase technology will yield accurate information allowing investigation of tolerance.

*Methods: Through the Applied Biomarkers of Late Effects of Childhood Cancer (ABLE) study (Cuvelier et al. 2019, Blood) plasma samples were collected from 287 patients at 27 sites at timepoints pre-HCT/pre-conditioning and 3, 6, 12 and 24 months post-HCT. Age at HCT was 0.2-17.9 (median 9.3) years. Donors and recipients were ABO-typed. Of HCT, 47% were ABO-mismatched. ABO Ab, including isotype and ABH-subtype specificity, was assessed by our newly-developed ABH-glycan microarray (Jeyakanthan et al. 2016, Amer J Transplant).

*Results: Ab to recipient A/B antigens were undetectable in most patients after ABO-mismatched HCT (O into A; O into B; O into AB). In contrast, Ab to ‘third-party’ A/B antigens and alpha-gal (a-gal) were detected in most patients pre- and post-ABO-matched/mismatched HCT. ‘O into A’ patients are shown in Fig 1A: most have undetectable IgM and IgG anti-A (subtypes I-IV) Ab both pre- and post-HCT, whereas anti-B and anti-a-gal Ab were detected (although not in all patients) pre- and post-HCT. In comparison, IgM and IgG anti-A and anti-B subtype I-IV Ab (and a-gal) were present at variable levels in ABO-matched ‘O into O’ patients (Fig 1B).

*Conclusions: The absence of Ab to recipient A/B antigens in the presence of third-party ABO/a-gal Ab after ABO-mismatched HCT is consistent with development of recipient-specific ABO tolerance in the donor-derived immune system. Delineating mechanisms of ABO tolerance in the HCT environment using solid-phase technologies may lead to more opportunities for safe ABOi solid organ transplantation.

 border=

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Motyka B, Halpin A, Pearcey J, Kariminia A, Halevy A, Maier S, Halevy A, Subrt P, Cairo CW, Cuvelier GD, Schultz KR, West LJ. ABH Subtype-Specific Tolerance after ABO-Mismatched Hematopoietic Cell Transplantation [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/abh-subtype-specific-tolerance-after-abo-mismatched-hematopoietic-cell-transplantation/. Accessed February 28, 2021.

« Back to 2020 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.