Articles tagged "Bone marrow transplantation"

2019 American Transplant Congress
JAK Inhibitor as a Novel Conditioning Approach to Establish Mixed Chimerism and Prevent Type 1 Diabetes Nonmyeloablatively
H. Xu¹, A. Merchak¹, J. Xu², Y. Huang¹, S. T. Ildstad¹
¹University of Louisville, Institute for Cellular Therapeutics, Louisville, KY, ²DuPont Manual High School, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of islet β cells. T1D has been found to be associated…
2019 American Transplant Congress
Galectin-3 Levels Are Associated with the Incidence and Severity of Chronic GVHD One Year after Allogeneic Hematopoietic Cell Transplantation
N. Navarro-Alvarez¹, A. R. Andrews¹, Z. DeFilipp², Y. A. Chen², V. T. Ho³, J. Ritz³, T. R. Spitzer⁴, C. A. Huang⁵
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, MA, ³Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA, ⁴Hematology/Oncology, Massachusetts General Hospital, Boston, MA, ⁵Plastic & Reconstructive Surgery and Transplant Surgery Divisions, University of Colorado, Denver, Aurora, CO
*Purpose: Chronic graft-versus-host disease (cGVHD) is a frequent complication of allogeneic hematopoietic cell transplantation (HCT) and a leading cause of late morbidity and mortality. T-…
2019 American Transplant Congress
Quality of Life in Tolerant Living Donor Kidney Transplants vs. Standard of Care
D. Tollerud¹, J. Leventhal², J. Galvin², J. Mathew², L. Gallon², D. Stare², J. Miller², M. Abecassis², S. Ildstad³
¹Regenerex, Inc., Louisville, KY, ²Northwestern U, Chicago, IL, ³U of Louisville, Louisville, KY
*Purpose: 37 subjects have been transplanted since 2009 in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts. The protocol…
2019 American Transplant Congress
Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice
Y. Huang, H. Xu, Y. Wen, S. Ildstad
University of Louisville, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…
2018 American Transplant Congress
A Novel Conditioning Approach to Establish Chimerism Using Manipulation of JAK-STAT Pathways
H. Xu, A. Merchak, L. Kahn, A. Chhabra, Y. Wen, Y. Huang, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Hematopoietic chimerism establishes donor-specific tolerance to solid organ allografts. Targeting recipient immune cells (T, NK cells and macrophages) can effectively reduce the dose of total…
2018 American Transplant Congress
Characterization of Renal Allograft Tolerance Induction via Transient Mixed Chimerism in Non-Human Primates
H. Sasaki,¹ C. Thaiss,¹ T. Oura,¹ A. Rosales,² R. Smith,² R. Colvin,² B. Cosimi,¹ T. Kawai.¹
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston; ²Pathology, Massachusetts General Hospital, Boston.
Background: We have previously reported long-term renal allograft tolerance after induction of transient mixed chimerism in non-human primates. However, some recipients developed late onset chronic…
2018 American Transplant Congress
Post-Transplant High Dose Cyclophosphamide Treatment Induces Thymus-Independent Immune Tolerance of Vascularized Composite Allografts via Complete Depletion of the Alloreactive TCR Repertoire.
G. Furtmüller,¹ B. Oh,¹ J. Sidhom,² M. Fryer,¹ V. Malek,¹ X. Zhou,¹ D. Cooney,¹ C. Brayton,³ J. Dodd-o,⁴ S. Ganguly,² G. Raimondi,¹ W. Lee,¹ L. Luznik,² G. Brandacher.¹
¹Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD; ²Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD; ³Department for Comparative Pathobiology, Johns Hopkins University, Baltimore, MD; ⁴Department of Anesthesiology, Johns Hopkins University, Baltimore, MD.
Background: Treatment with PT/Cy in the setting of combined donor bone marrow transplantation and VCA has shown encouraging results with regards to chimerism induction and…
2018 American Transplant Congress
CD4⁺CD25^bright Regulatory T Cells Prevent Acute Xenogeneic GVHD
Y. Huang, A. Merchak, H. Xu, A. Chhabra, A. Khalil, Y. Wen, M. Binion, M. Badder, L. Kahn, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Graft-versus-host disease (GVHD) is a major complication and limitation to the broad application of hematopoietic stem cell transplantation. Cell therapy has emerged as a promising…
2018 American Transplant Congress
Low Intensity Conditioning Protocol for Inducing Chimerism-Based Tolerance in Non-Obese Diabetic Mice
A. Chhabra, Y. Huang, H. Xu, A. Merchak, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Type 1 diabetes is the most common chronic disease affecting children. Islet cell or pancreas transplantation offer the most physiologic approach to glucose homostasis. However…
2018 American Transplant Congress
Outcomes after Kidney Transplantation in Patients with AL Amyloid Following Autologous Stem Cell Transplantation
V. Gutgarts,^1,2 I. Jaffer Sathick,² C. Rosenbaum,³ T. Muthukumar,¹ H. Hassoun,⁴ C. Flombaum,² H. Landau.⁴
¹Nephrology, Weill Cornell, NY; ²Renal Medicine, Memorial Sloan Kettering, NY; ³Hematology, Weill Cornell, NY; ⁴Hematology, Memorial Sloan Kettering, NY.
BackgroundAL amyloidosis results in kidney failure in about 15-30% of patients and is considered a relative contraindication for kidney transplantation. There is limited data on…