ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Biopsy"

  • 2015 American Transplant Congress

    Gene Expression Profiles Indicate That Many Discarded Kidneys Are Potentially Transplantable

    K. Famulski,1 S. Niederhaus,2 J. Reeve,1 J. Bromberg,2 P. Halloran.

    1University of Alberta, Edmonton, Canada; 2University of Marlyland, Baltimore.

    We previously showed that the molecular kidney injury-repair response (AKI score) in implantation core biopsies (Bx) predict future graft function better than histology. This could…
  • 2015 American Transplant Congress

    Arterial Blood Pressure at Time of Liver Transplant (LT) Evaluation Correlates With Kidney Biopsy Findings in LT Candidates With Renal Dysfunction

    H. Wadei, A. Peguero, A. Alsaad, M. Mai, K. Oshel, T. Gonwa, C. Taner, A. Keaveny.

    Transplant, Mayo Clinic, Jacksonville, FL.

    Renal dysfunction is common in LT candidates; however, predicting post-LT renal recovery is sometimes difficult. Kidney biopsy is helpful in identifying reversible renal injury but…
  • 2015 American Transplant Congress

    End of Treatment Liver Biopsy With Sofosbuvir: Histologic Changes Suggestive of Hepatitis C Activity in Liver Transplant Recipients With Achieved SVR

    B. Ismail,1 X. Zervos,1 P. Bejarano,2 M. Waton,1 D. Beltran,3 D. Sears,1 A. Tzakis.1

    1Liver Transplant, Cleveland Clinic Florida, Weston, FL; 2Pathology, Cleveland Clinic Florida, Weston, FL; 3Pharmacy, Cleveland Clinic Florida, Weston, FL.

    Background: Interferon (IFN) free HCV regimens are associated with better tolerability and efficacy. The majority of studies report biochemical and virological response; however limited information…
  • 2015 American Transplant Congress

    The Influence of Immunosuppressive Drugs On the Epithelial Microenvironment in Solid Organ Transplantation – Identification of Biomarker Candidates for Rejection Vs. Tolerance

    A. Akhdar,1 B. Mueller,2 C. Neudoerfl,1 F. Lehner,3 M. Stevanovic-Meyer,1 K. Daemen,1 J. Keil,1 H. Haller,4 C. Blume,4,5 C. Falk.1,6

    1Institute of Transplant Immunology, IFB-Tx, Hanover Medical School, Hanover, Germany; 2MorphoSys, Munich, Germany; 3Department of General, Visceral and Transplantation Surgery, Hanover Medical School, Hanover, Germany; 4Department of Nephrology and Hypertension, Hanover Medical School, Hanover, Germany; 5Institute of Technical Chemistry, Leibniz University Hanover, Hanover, Germany; 6German Center for Infection Research, Braunschweig, Germany.

    In the context of kidney transplantation, NK cells may play an important role by targeting the allogeneic organ due to "missing-self recognition", which leads to…
  • 2015 American Transplant Congress

    Multicenter Validation of a Molecular Diagnostic for Antibody-Mediated Rejection in Formalin-Fixed Paraffin-Embedded Human Renal Allograft Biopsies

    B. Adam,1 B. Afzali,1 N. Shah,1 K. Dominy,2 R. Gill,1 L. Hidalgo,1 P. Campbell,1 C. Roufosse,2 M. Mengel,1 B. Sis.1

    1University of Alberta, Edmonton, Canada; 2Imperial College, London, United Kingdom.

    Background: In 2013, the Banff classification adopted molecular diagnostics as an adjunct for the diagnosis of antibody-mediated rejection (ABMR) in renal allografts. The NanoString gene…
  • 2015 American Transplant Congress

    Hybrid Ostomy – New Technique in Intestinal Transplantation

    T. Beduschi, J. Garcia, P. Ruiz, A. Tekin, G. Selvaggi, S. Nishida, J. Fan, R. Vianna.

    Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL.

    Introduction: Many experimental non-invasive methods have been tested to assess the intestinal graft, but none of them proved to be reliable. Biopsy of the intestine…
  • 2015 American Transplant Congress

    Explorative Analysis of ZEUS After 5 Years: Histological Assessment from Biopsy Analyses

    U. Eisenberger,1 K. Budde,1 O. Witzke,1 F. Lehner,1 C. Sommerer,1 R. Wuethrich,3 P. Reinke,1 A. Muehlfeld,1 K. Heller,1 R. Stahl,1 H. Wolters,1 I. Hauser,1 M. Porstner,2 W. Arns.1

    1ZEUS Study Group, Germany; 2Novartis, Pharma, Germany; 3ZEUS Study Group, Switzerland.

    Background: Analysis of pathologists' assessments and histological data allow for deeper insight on patient outcome together with investigator's final clinical diagnoses. Here we present 5…
  • 2015 American Transplant Congress

    De Novo DSA Would Not Necessarily Cause Graft Rejection After Renal Transplantation: Characteristics of DSA Developing Biopsy-Proven Chronic Antibody-Mediated Rejection

    T. Yamamoto, Y. Watarai, A. Takeda, M. Okada, M. Tsujita, H. Takahisa, N. Goto, S. Narumi, T. Kobayashi.

    Kidney Center, Nagoya Daini Red Cross Hospital, Nagoya, Japan.

    Introduction:De novo donor-specific HLA antibodies (dn DSA) production after renal transplantation has been reported to be associated with chronic antibody mediated rejection (CAMR), which leads…
  • 2015 American Transplant Congress

    A Single Center Study on Pregnacy and Allograf Function Outcomes Post Heart Transplant

    S. Adams, M. Wigger.

    Heart Transplant, Vanderbilt Medical Center, Nasvhille, TN.

    Pregnancy is a special time during a young woman's life, especially more so in those young women who are post heart transplant. The purpose of…
  • 2015 American Transplant Congress

    Reduction of Tacrolimus With Everolimus Addition in Maintenance Immunosuppression Improves Calcineurin Inhibitor-Induced Arteriolopathy in Kidney Allografts

    M. Miura,1 H. Higashiyama,1 Y. Fukasawa.2

    1Department of Renal Transplant Surgery, Sapporo Hokuyu Hospital, Sapporo, Japan; 2Department of Pathology, Sapporo City General Hospital, Sapporo, Japan.

    Objectives: Although conversion of calcineurin inhibitor (CNI)-based immunosuppression to everolimus (EVR) has been shown to improve graft function, no histopathological evidence has been reported. The…
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