2015 American Transplant Congress
Inflammation in Regions of Tubular Atrophy (IATR) Predicts Adverse Graft Outcome in Patients With Late Graft Dysfunction: A Multicenter Study
Purpose: Inflammation in regions of tubular atrophy (IATR) is a risk factor for late graft loss. However, IATR is associated with inflammation in non-atrophic regions…2015 American Transplant Congress
Histological Analysis in ABO-Compatible and Incompatible Kidney Transplantation By Performing 3-Month and 1-Year Protocol Biopsies
Background. ABO incompatible kidney transplantation (ABO-I KTx) is nowadays a well-established procedure to expand living donor source. Graft and patient survivals of ABO-I KTx were…2015 American Transplant Congress
Intra-Renal Cytokine Measurement Detected During Kidney Allograft Biopsies Portend Severity of Histological Injury
Division of Nephrology, University of Washington, Seattle, WA.
Histological changes observed on renal allograft biopsies, although considered the current standard for evaluation of allograft injury, lack specificity and disease activity assessment. We devised…2015 American Transplant Congress
A Comparative Analysis of Histological Scoring in Living Donor Renal Transplants from Donors Above and Below 60 Years of Age
BACKGROUND AND OBJECTIVES: World Health Organisation estimates that the absolute number of people aged 60yrs and over will increase from 605-million to 2-billion over the…2015 American Transplant Congress
Tacrolimus for the Treatment of Refractory Biopsy-Proven Acute Cellular Rejection in Patients on Belatacept-Based, CNI- and Steroid-Free Immunosuppression Regimens
1Univ of Cincinnati, Cincinnati; 2The Christ Hospital, Cincinnati.
Background: Tacrolimus (TAC) is effective as rescue treatment (tx) in renal transplant patients (pts) on cyclosporine-based immunosuppression (IS) who have recurrent or resistant acute rejection…2015 American Transplant Congress
Anti-Donor T-Cell Immunity Is a Continuum Immune Process Favouring Subclinical Rejection After Kidney Transplantation
Subclinical T-cell mediated rejection (sc-TCR) accounts for a major cause of kidney allograft loss and is unexpectedly found in a rather important number of protocol…2015 American Transplant Congress
Glomerulosclerosis Patterns Are Non-Uniform Throughout the KDPI Spectrum With Impact on Biopsy Evaluation of Kidneys for Transplant
1Gift of Hope Organ & Tissue Donor Network, Itasca, IL; 2Rush University, Chicago, IL.
Background: The kidney donor profile index (KDPI) stratifies kidney quality with direct bearing on organ allocation and utilization. Procurement biopsy is commonly performed and factored…2015 American Transplant Congress
Reassessing Tubulitis and Interstitial Infiltrate: Creating a New Probabilistic Definition of TCMR
Alberta Transplant Applied Genomics Centre, Edmonton, Canada.
Conventional diagnosis of T cell-mediated rejection (TCMR) in kidney transplant biopsies relies on interstitial inflammation (i-lesions), tubulitis (t-lesions), vasculitis (v-lesions) and experience-derived interpretation rules. The…2015 American Transplant Congress
Intra-Allograft Common Rejection Module (CRM) Expression in Kidney Transplants Diagnoses Acute Rejection and Predicts Long Term Graft Prognosis
Surgery, UC San Francisco, San Francisco, CA.
Background: Previous studies with cross-organ transcriptional analysis of 794 allograft biopsies from kidney, liver, heart and lung transplant patients identified a common rejection module (CRM)…2015 American Transplant Congress
Histopathological Criteria for Elevated Risk of Delayed Graft Function in German Pretransplantation Kidney Biopsies from Deceased Donors
Introduction:Delayed graft function (DGF) is more frequent with so called marginal kidney donors. Moreover, it is linked to increased recipient mortality and inferior transplant outcome.…
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