2016 American Transplant Congress
Microarray Analysis of Transbronchial and Mucosal Biopsies in Lung Transplant Recipients Detects Molecular Changes of T-Cell Mediated Inflammation.
Purpose: The main diagnostic platform for rejection in lung transplant recipients is histology of transbronchial biopsies (TBB), a test with a poor performance and safety…2016 American Transplant Congress
Role of Natural Killer Cells in Kidney Transplant Outcome.
Aim of the study was to evaluate the relationship between killer cell immunoglobulin-like receptor (KIR) phenotype and kidney transplant rejection. NK-target cell interaction depends on…2016 American Transplant Congress
Interaction Between Kidney Tissue Proteome and Humoral Immunity in Antibody Mediated Rejection.
PURPOSE: Antibody-mediated rejection (AMR) is caused by antibodies against human leukocyte antigens (HLA) on graft endothelium, and non-HLA antibodies that target endothelial and epithelial proteins.…2016 American Transplant Congress
Mapping Heterogeneity in Antibody-Mediated Rejection Using Molecular Phenotypes and Archetype Analysis.
Archetype analysis is a method for identifying new relationships among samples without subdividing them into classes, finding a limited number of archetypical cases and calculating…2016 American Transplant Congress
Predictors of Early Rejection and Allograft Failure in Pediatric Kidney Transplantation: Impact of Histology and Behavior.
University of Alabama at Birmingham School of Medicine, Birmingham.
Background: Early inflammatory events that lead to allograft dysfunction are often missed by creatinine-based estimates in children. Surveillance biopsies can detect early allograft dysfunction due…2016 American Transplant Congress
Chronic Infection by Hepatitis C Virus and the Development of Transplant Glomerulopathy.
OBJETIVE: To demonstrate that chronic infection with the hepatitis C virus (HCV) is a risk factor for the development of transplant glomerulopathy in a large…2016 American Transplant Congress
Standardized Pre-Implantation Kidney Biopsies of Expanded Criteria Donors to Improve the Kidney Donor Profile Index (KDPI) for the Evaluation of Marginal Donors.
There is no consensus of selection criteria used to allocate renal transplants from expanded criteria donors (ECD). The Kidney Donor Profile Index (KDPI) has been…2016 American Transplant Congress
Everolimus with Low-Dose Tacrolimus vs. a Standard Immunosuppressive Regimen: Renal Histology at 6 Months in De Novo Renal Transplant Patients.
Morphologic changes in transplant protocol biopsies provide early evidence of renal damage. This study examined the renal histology of de novo patients 6 months post…2016 American Transplant Congress
Long-Term Deterioration of Graft Function (DeKAF) Study: Histologic Interpretation of Cross-sectional vs Prospective Cohorts.
1U of MN, Mpls, MN; 2U IA, Iowa City, IA; 3Mayo, Rochester, MN.
The major aim of the DeKAF study was to define previously unidentified phenotypes resulting in late graft dysfunction and loss (GL). Two cohorts were developed,…2016 American Transplant Congress
Elevated Intragraft Expression of Innate Immunity and Cell Death-Related Markers Characterizes Deceased Donor Conditions and Is a Risk Factor for Adverse Graft Outcome.
Background: The innate immune response is increasingly being recognized in allograft injury after kidney transplantation. We aimed to establish the relationship of innate immune gene…
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