End of Treatment Liver Biopsy With Sofosbuvir: Histologic Changes Suggestive of Hepatitis C Activity in Liver Transplant Recipients With Achieved SVR
B. Ismail,1 X. Zervos,1 P. Bejarano,2 M. Waton,1 D. Beltran,3 D. Sears,1 A. Tzakis.1
1Liver Transplant, Cleveland Clinic Florida, Weston, FL
2Pathology, Cleveland Clinic Florida, Weston, FL
3Pharmacy, Cleveland Clinic Florida, Weston, FL.
Meeting: 2015 American Transplant Congress
Abstract number: A197
Keywords: Biopsy, Hepatitis C, Liver transplantation, Viral therapy
Session Information
Session Name: Poster Session A: Liver Transplantation: Viral Hepatitis
Session Type: Poster Session
Date: Saturday, May 2, 2015
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Exhibit Hall E
Background: Interferon (IFN) free HCV regimens are associated with better tolerability and efficacy. The majority of studies report biochemical and virological response; however limited information has been published on histologic findings. Aim: Report histologic findings following sustained virological response (SVR) in LT patients (pts). Methods: HCV treatment was started between 12/2013 and 5/2014 on pts who underwent LT between 1990 and 2014. Sofosbuvir (SOF) started in all 17 pts, 8 pts treated with SOF and Ribavirin (RBV), 2 pts SOF/RBV switched to SOF and Simeprevir (SIM), 6 pts treated with SOF/SIM and one with SOF/RBV/IFN (co-infection with HIV). All but 1 pt was on tacrolimus.
Mean age (range) | 64 (53-80) |
Gender (M:F) | 11:6 |
Race (Caucasian:Hispanic) | 15:2 |
Mean AST (range) | 54 (12-172) U/L |
Mean ALT (range) | 59 (9-166) U/L |
Mean prior to treatment RNA level (range) | 29.6 (1.24 105.9) x10 5 IU/mL |
HCV Genotype | 1a (11 patients), 1a or 1b (2), 1b (1), 2b (1), 3 (2) |
Cirrhosis prior to treatment | 5 patients |
To cite this abstract in AMA style:
Ismail B, Zervos X, Bejarano P, Waton M, Beltran D, Sears D, Tzakis A. End of Treatment Liver Biopsy With Sofosbuvir: Histologic Changes Suggestive of Hepatitis C Activity in Liver Transplant Recipients With Achieved SVR [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/end-of-treatment-liver-biopsy-with-sofosbuvir-histologic-changes-suggestive-of-hepatitis-c-activity-in-liver-transplant-recipients-with-achieved-svr/. Accessed October 3, 2024.« Back to 2015 American Transplant Congress