2020 American Transplant Congress
High-Activity Classical and Alternative Complement Pathway Genotypes – Association with Donor-Specific Antibody-Triggered Injury and Renal Allograft Survival
*Purpose: Complement may contribute to donor-specific antibody (DSA)-triggered transplant injury. Here, we investigated whether the intrinsic strength of classical (CP) and alternative complement pathways (AP)…2020 American Transplant Congress
Donor-Derived Cell-Free DNA Combined with Histology Improves Prediction of eGFR Decline in Kidney Transplant Recipients over Histology Alone
*Purpose: Higher Banff inflammation and chronicity scores on kidney transplant (KTx) biopsies (Bx) have been associated with poorer graft survival, but Bx scores alone imperfectly…2020 American Transplant Congress
From Marginal to Meaningful: Donor Liver Biopsy Increases Donation Rates amongst Elderly Donors
*Purpose: Recently, there has been public scrutiny on the non-utilization of elderly donors in liver transplantation. Here, we evaluate the influence of donor liver biopsy…2020 American Transplant Congress
Microvascular Inflammation without DSA or C4d: An Orphan Category in Banff Classification with Intense Capillaritis and Cytotoxic T-Cell Infiltration
*Purpose: Antibody-mediated rejection (ABMR) associated with donor-specific HLA antibodies (DSA) is the leading cause of late allograft failure after kidney transplantation. Microvascular inflammation (MVI) without…2020 American Transplant Congress
Kidney Procurement Biopsy Technique Does Not Determine Histologic Accuracy
Medicine-Nephrology, Columbia University, New York, NY
*Purpose:Procurement biopsies (PBx) are commonly used to evaluate the quality of deceased donor kidneys (DDK). However, the validity of PBx biopsy interpretation has been questioned,…2020 American Transplant Congress
Time-Zero Histology Correlates with Donor Characteristics but Does Not Predict Short-Term Outcomes in Kidney Transplantation
University of Alabama School of Medicine, Birmingham, AL
*Purpose: Time-zero biopsies provide important information about baseline histology but their clinical utility compared to other non-invasive predictors is unclear. Our center performs universal time-zero…2020 American Transplant Congress
Incidence of Skin Cancer – A Long Term Outcome of Immunosuppression in Renal Transplant Recipients Associated with the Usage of Azathioprine
*Purpose: The main cause of mortality in Kidney Transplant Recipient’s (KTRs) is malignancy. The cancer incidence is increased by treating with immunosuppressive agents and longer…2020 American Transplant Congress
Should Steatotic Livers Be Transplanted Into Pediatric Recipients?
*Purpose: Although steatotic livers are frequently transplanted in the adult population, they are not commonly transplanted in pediatric recipients. We questioned if the outcomes of…2020 American Transplant Congress
Temporal Trends in Utilization and Outcomes of Sclerotic Donor Kidneys in the United States
Johns Hopkins University, Baltimore, MD
*Purpose: Sclerotic donor kidneys (SDK, glomerulosclerosis ≥20% on biopsy) represent a possible expansion to the donor pool but are often discarded due to historical association…2020 American Transplant Congress
Hif-1a Expression Influences Recipient Clinical Outcomes in Liver Transplant Patients
Liver Transplant Surgery, UCLA, Los Angeles, CA
*Purpose: Liver ischemia-reperfusion injury (IRI), an innate-immune dominated hepatocellular damage, is a risk factor for early allograft dysfunction (EAD) and rejection crises in liver transplantation…
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