ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Biopsy"

  • 2022 American Transplant Congress

    Role of Circulating Tumour Cells in the Management of the Liver Transplant Patient with Hepatocellular Carcinoma

    F. Villalba1, F. Alconchel2, L. Sáenz3, M. Sánchez-Lorencio1, D. Ferreras2, P. Cascales2, F. Sánchez-Bueno2, R. Robles2, P. Ramírez2

    1IMIB-Virgen de la Arrixaca, Murcia, Spain, 2Surgery and Organ Transplantation, Virgen de la Arrixaca University Hospital (IMIB-Virgen de la Arrixaca), Murcia, Spain, 3Rafael Méndez Hospital, Lorca, Spain

    *Purpose: For hepatocellular carcinoma (HCC), liver transplantation (LT) is considered a curative treatment, however, more than 10% of transplant recipients have recurrences within the first…
  • 2022 American Transplant Congress

    Deep Phenotyping Methods Highlight Recipient-Derived CD16+ NK and CD16+ Monocyte Infiltration During Kidney Transplant Rejection

    B. Lamarthée1, J. Callemeyn1, P. Koshy2, T. Debyser3, E. Van Loon1, A. Franken4, T. Van Brussel4, I. Arijs4, D. Lambrechts4, A. Senev1, T. Vaulet5, C. Tinel1, M. Naesens1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium, 3Faculty of Medicine, KU Leuven, Leuven, Belgium, 4Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, 5ESAT Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium

    *Purpose: How the immune system participates to kidney transplant rejection has not been fully elucidated. Single-cell (sc) genomics techniques are revolutionizing our ability to characterize…
  • 2022 American Transplant Congress

    Spatially Resolved Molecular Profiling of Endothelial Cells in Antibody-Mediated Kidney Transplant Rejection

    M. Melendez-Ferro, D. R. Kelly, M. E. Seifert

    UAB School of Medicine, Birmingham, AL

    *Purpose: Endothelial cells are key targets of alloimmune injury in antibody-mediated rejection (ABMR), but are challenging to study in situ using high-throughput methods. We aimed…
  • 2022 American Transplant Congress

    Can dd-cf DNA Eliminate Unnecessary Biopsies? The Answer is Yes!

    K. Andreoni, Y. Chalicheemala, M. Debroy, M. Maklad, K. Zhao, M. Aeder, A. Jittirat, D. Ecabert, A. Bixby, C. Burrelli, K. Chavin

    University Hospitals Cleveland Medical Center, Cleveland, OH

    *Purpose: Historically our center has been one that routinely performs biopsies. We perform them pre-perfusion, for slowly recovering allografts between day 10-14, and routinely at…
  • 2022 American Transplant Congress

    Establishment And Validation Of A Predictive Model For Differential Rejection Diagnosis By Gene Expression Profiling (GEP) In Renal Allograft Biopsies Using Banff Human Organ Transplant (B-HOT) Gene Panel

    H. Zhang1, R. Haun2, F. Collin1, C. Cassol2, S. Coley2, J. Wilson2, S. Stone1, K. Qu1, W. Tian1, N. Agrawal1, G. Shekhtman1, C. Larsen2

    1CareDx, Inc., Brisbane, CA, 2Arkana Laboratories, Little Rock, AR

    *Purpose: Large scale GEP studies evaluating the performance of Banff-endorsed B-HOT gene panel for allograft rejection diagnosis have not been published. In this study, we…
  • 2022 American Transplant Congress

    Antibody-Mediated Allograft Rejection is Associated with an Increase in Peripheral Differentiated Cd28-cd8+ T Cells – Analyses of a Cohort of 1032 Kidney Transplant Recipients

    H. L. Mai1, N. Degauque1, S. Le Bot1, M. Rimbert1, K. Renaudin1, R. Danger1, F. Le Borgne2, C. Kerleau1, F. Delbos3, M. Giral1, S. Brouard1

    1UMR 1064 - CRTI, INSERM - CHU de Nantes, Nantes, France, 2UMR 1046 - SPHERE, INSERM - IDBC-A2COM, Nantes, France, 3Etablissement Français du Sang (EFS) - CHU de Nantes, Nantes, France

    *Purpose: CD28-CD8+ T cells represent a differentiated CD8+ T cell subset that is found to be increased in various conditions associated with chronic antigenic stimulation…
  • 2022 American Transplant Congress

    Recoverability of Diabetic Nephropathy of Donor Kidney After Kidney Transplantation

    K. Lee, J. Park

    Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: The natural course of diabetic donors on the outcome of kidney transplantation (KT) is controversial. The aim of this study was to analyze the…
  • 2022 American Transplant Congress

    Acute Tubular Injury and Necrosis Do Not Lead to Meaningful Elevations in Donor-Derived Cell-Free DNA (dd-cfDNA)

    S. R. Allam1, M. Cooper2, D. Kumar3, T. Maw4, A. Wiseman5, P. Chuang6, G. Shekhtman7, N. Agrawal7, J. Zeng7, E. Huang8

    1Medical City Transplant Institute, Fort Worth, TX, 2Medstar Georgetown Transplant Institute, Washington, DC, 3Virginia Commonwealth University, Richmond, VA, 4University of Southern California, Los Angeles, CA, 5Centura Health, Denver, CO, 6Metrolina Nephrology, Charlotte, NC, 7CareDx, Brisbane, CA, 8Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: Associations between non-rejection histologic diagnoses and dd-cfDNA have not been extensively characterized. We explored these associations in kidney transplant recipients enrolled in the Kidney…
  • 2022 American Transplant Congress

    Digital Spatial Profiling of Kidney Allograft Biopsies with Chronic Allograft Dysfunction in African American Transplant Recipients

    C. R. Dorr1, S. A. Elmer1, B. Wu2, B. Guo2, J. Czyzyk2, G. Crary3, G. Onyeaghala1, W. Oetting2, P. Jacobson2, R. B. Mannon4, G. Agarwal5, J. Maltzman6, A. Matas2, A. Israni3

    1Hennepin Healthcare Research Institute, Minneapolis, MN, 2University of Minnesota, Minneapolis, MN, 3Hennepin County Medical Center, Minneapolis, MN, 4Medicine, University of Nebraska Medical Center, Omaha, NE, 5University of Alabama at Birmingham, Birmingham, AL, 6Stanford University, Palo Alto, CA

    *Purpose: Understanding tissue heterogeneity is important to identify the molecular and cellular mechanisms of kidney allograft loss in African American (AA) transplant recipients. Our aim…
  • 2022 American Transplant Congress

    Use of Everolimus and Reduced Calcineurin Inhibitors in Bk Nephropathy: Insights from Follow-Up and Surveillance Biopsies

    Z. S. Zaky, M. Spinner, B. Stephany

    Cleveland Clinic, Cleveland, OH

    *Purpose: BK virus-associated nephropathy (BKVAN) is a clinically important entity that results in an allograft loss in kidney transplant recipients (KTRs). Mammalian target of rapamycin…
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