Articles tagged "Biopsy"

2020 American Transplant Congress
Natural Course of Borderline Changes in Kidney Allografts: A MMDx Study
P. Hruba¹, K. S. Madill-Thomsen², M. Mackova², J. Maluskova³, E. Honsova³, J. Slatinska⁴, P. F. Halloran², O. Viklicky⁴
¹Transplant Laboratory, IKEM, Prague, Czech Republic, ²ATAGC, University of Alberta, Edmonton, AB, Canada, ³Department of Pathology, IKEM, Prague, Czech Republic, ⁴Department of Nephrology, IKEM, Prague, Czech Republic
*Purpose: Molecular assessment of kidney allograft biopsies with Banff borderline changes (BL) category has showed only 30% of rejection phenotype in various post-transplant follow-up and…
2020 American Transplant Congress
Impact of Variation in Histological Assessments and Their Impact on Clinical Trial Enrollment and Endpoints – Preliminary Report of The Gen04 Study
W. Park¹, M. Ryan², L. Herrera Hernandez³, M. Smith², X. Geiger⁴, T. Sandor⁵, L. Cornell³, M. Stegall¹
¹Transplant Center, Mayo Clinic, Rochester, MN, ²Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ, ³Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, ⁴Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, ⁵Pathology, University of Szegad, Szegad, Hungary
*Purpose: Renal allograft histology is often used as inclusion criteria for clinical trials. This includes Gen04, which is an NIH sponsored multi-center clinical trial involving…
2020 American Transplant Congress
Machine Learning to Predict Deceased Donor Kidney Biopsy Results
C. Martinez, A. Placona
United Network for Organ Sharing, Richmond, VA
*Purpose: Despite inconclusive evidence that kidney biopsy findings are associated with graft outcomes, biopsies are often cited as a key factor on whether to accept…
2020 American Transplant Congress
Calcium Oxalate Deposition in Kidney Allografts: Clinical Chracteristics and Outcome
S. Sritharan¹, J. Kamal², S. A. Husain¹, I. Batal¹, J. Chang¹
¹Columbia University Irving Medical Center, New York, NY, ²University of Virginia, Charlottesville, VA
*Purpose: To better understand its clinical significance and prognostic value, we investigated the clinical characteristics and outcomes of patients with calcium oxalate deposition in kidney…
2020 American Transplant Congress
The Role of the Molecular Microscope to Guide Therapy for T-Cell Mediated Rejection in Kidney Transplants
D. Kumar¹, M. Demehin¹, J. Christensen¹, L. Kamal¹, I. Moinuddin¹, M. Levy¹, C. Bhati¹, A. King¹, H. D. Massey¹, P. Halloran², G. Gupta¹
¹Virginia Commonwealth University, Glen Allen, VA, ²ATAGC, Edmonton, AB, Canada
*Purpose: Histologic lesions (I+T) to characterize T-cell mediated rejection (TCMR) can be non-specific. In some cases the inflammation may represent a ‘response to wounding’ rather…
2020 American Transplant Congress
Impact of Severity of Glomerulosclerosis on Long-Term Outcomes in Deceased Donor Renal Transplant Recipients with Donor Acute Kidney Injury
A. Brar¹, A. Gruessner², D. Adey¹, M. Salifu²
¹University of California, San Francisco, San Francisco, CA, ²SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: With long waitlist times for renal transplantation,there is a need to reduce discard rates of donor kidneys.The purpose of this study is to assess…
2020 American Transplant Congress
Calcium Phosphate Crystals: An Under Recognized Cause of Kidney Allograft Injury?
R. H. Naik, E. Ramos, B. Paueksakon, M. Anand, A. Fogo, B. P. Concepcion, M. Lusco
Vanderbilt University Medical Center, Nashville, TN
*Purpose: Calcium phosphate (CaPhos) crystals are a known cause of dysfunction in native kidneys. Our objectives were to describe the incidence of CaPhos crystal deposition…
2019 American Transplant Congress
C4d Positivity in Renal Biopsies Following A₂ to B Kidney Transplantation: Not All A B O Incompatibilities Are Equal
S. Radomski¹, G. Vranic², B. Thomas², P. Abrams², M. Cooper², A. Gilbert²
¹Georgetown University School of Medicine, Washington, DC, ²Medstar Georgetown Transplant Institute, Washington, DC
*Purpose: With the new allocation rules implemented in 2014, the number of transplants from A2 and A2B donors to B or O recipients (minor ABO…
2019 American Transplant Congress
CNI-Free Therapy with Iscalimab (anti-CD40 mAb) Preserves Allograft Histology Compared to Standard of Care after Kidney Transplantation
E. Farkash¹, A. Naik¹, H. Tedesco-Silva², B. Nashan³, O. Witzke⁴, M. van den Hoogen⁵, S. Berger⁶, D. M. Cibrik⁷, S. Mulgaonkar⁸, D. B. Leeser⁹, R. Alloway¹⁰, A. Patel¹¹, J. Pratchke¹², C. Sommerer¹³, A. Wiseman¹⁴, A. Van Zuilen¹⁵, U. Laessing¹⁶, J. Rush¹⁶, B. Haraldsson¹⁶
¹Univ of Michigan, Ann Arbor, MI, ²Hospital do Rim, São Paulo, Brazil, ³Univ. Hamburg, Hamburg, Germany, ⁴Univ Essen, Essen, Germany, ⁵Erasmus MC, Rotterdam, Netherlands, ⁶UMC Groningen, Gröningen, Netherlands, ⁷Univ of Kansas, Kansas City, KS, ⁸Saint Barnabas MC, Livingston, NJ, ⁹East Carolina Univ, Greenville, NC, ¹⁰Univ of Cincinnati, Cincinnati, OH, ¹¹Henry Ford Hosp, Detroit, MI, ¹²Charité Univ, Berlin, Germany, ¹³Univ Heidelberg, Heidelberg, Germany, ¹⁴Univ of Colorado SM, Denver, CO, ¹⁵Univ MC, Utrecht, Netherlands, ¹⁶Novartis, Basel, Switzerland
*Purpose: To assess if calcineurin (CNI)-free therapy with iscalimab preserves the quality of transplanted kidney grafts.*Methods: Iscalimab (CFZ533) is a new, fully human, Fc-silenced, non-depleting,…
2019 American Transplant Congress
Validation of Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) in Renal Allograft Biopsies (Bx) of HLA-Sensitized Patients
H. Zhang¹, C. C. Nast², N. Ammerman³, A. A. Vo³, S. C. Jordan³, M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: "Thoroughly validated gene transcripts” in renal Bx was adopted as one of the criteria for ABMR diagnosis in the latest Banff classification. Previously, we…