Articles tagged "Biopsy"

2019 American Transplant Congress
Kidney Biopsies In Hiv-negative To Hiv-positive Kidney Transplants – An Institutional Experience
V. Walavalkar¹, A. Zarinsefat², A. Urisman¹, D. Dobi¹, J. Vasquez³, P. Stock², Z. Laszik¹
¹Pathology, UCSF Medical Center, San Francisco, CA, ²Transplant Surgery, UCSF Medical Center, San Francisco, CA, ³Medicine, UCSF Medical Center, San Francisco, CA
*Purpose: Increased life expectancy in HIV+ patients has resulted in an increase in CKD leading to ESRD; and therefore renal transplantation in these individuals is…
2019 American Transplant Congress
Impact of T-cell Mediated Allograft Rejection and Antibody Mediated Rejection within the First Year after Kidney Transplantation
I. Owoyemi, D. Jorgensen, S. Tandukar, R. Mehta, S. Hariharan
Thomas E. Starzl Institute of Transplantation and Division of Transplant Nephrology, UPMC, Pittsburgh, PA
*Purpose: This study evaluated the impact of Clinical and Sub-clinical T-Cell-Mediated Rejection (TCMR), Sub-Clinical Inflammation and Antibody Mediated Rejection (ABMR) within the 1st year post-kidney…
2019 American Transplant Congress
Clostridium difficile Infection Mimics Intestinal Acute Cellular Rejection in Pediatric Multivisceral Transplant – A Case Series
D. A. Cheung¹, T. Beduschi², A. Tekin², G. Selvaggi², R. M. Vianna², J. Garcia¹
¹Pediatric Gastroenterology, University of Miami, Miami, FL, ²Surgery, Division of Liver/GI Transplant, University of Miami, Miami, FL
*Purpose: Clostridium difficile infection (CDI) is the most common healthcare-associated infection in the United States. One out of 8 recipients who undergo transplantation with more…
2019 American Transplant Congress
The Degree of Glomerulosclerosis in Procurement Renal Biopsy and its Implications in Predicting Graft Outcomes in Marginal Donor Kidneys
W. Cheungpasitporn¹, W. Chon², E. Island², L. Cummings², J. Forster², N. Leeaphorn²
¹University of Mississippi Medical Center, Jackson, MS, ²Saint Luke's Health System, Kansas City, MO
*Purpose: Percentage of glomerulosclerosis (GS) is a major determinant for kidney discard. However, GS failed to consistently predict graft outcomes across studies in the literature.…
2019 American Transplant Congress
Molecular Microscope Proves i-IFTA Lack of Specificity
A. Perkowska-Ptasinska¹, M. Ciszek², D. Deborska-Materkowska¹, A. Debska-Slizien³, P. F. Halloran⁴, M. Myslak⁵
¹Warsaw Medical Univeristy, Warsaw, Poland, ²Department of Immunology, Transplantology and Internal Diseases, Warsaw Medical Univeristy, Warsaw, Poland, ³Gdansk Medical University, Gdansk, Poland, ⁴ATAGC, University of Alberta, Edmonton AB, AB, Canada, ⁵Pomeranian Medical University, Szczecin, Poland
*Purpose: According to 2017 Banff classification, inflammatory infiltrate in the fibrotic renal tissue with at least moderate total inflammations score (ti≥2), and tubulitis (t≥2) should…
2019 American Transplant Congress
Molecular Phenotype of Proliferative Arteriopathy in Kidney Grafts
A. Perkowska-Ptasinska¹, M. Ciszek¹, D. Deborska-Materkowska¹, A. Debska-Slizien², P. F. Halloran³, M. Myslak⁴
¹Warsaw Medical University, Warsaw, Poland, ²Gdansk Medical University, Gdansk, Poland, ³University of Alberta, Edmonton AB, AB, Canada, ⁴Pomeranian Medical University, Szczecin, Poland
*Purpose: Proliferative arteriopathy (PA) is a lesion characterized by a fibrotic tissue in the arterial intima. The phenomenon is marked by the lack of elastic…
2019 American Transplant Congress
Renal Pathological Findings in Living Kidney Donor Candidates with Minimal Urinary Abnormalities
H. Ahmed¹, C. Drachenberg², R. Ugarte¹, N. Costa¹, C. Cangro¹, R. N. Barth³, M. Weir¹, A. Harirain¹
¹Medicine-Nephrology, University of Maryland Medical Center, Baltimore, MD, ²Pathology, University of Maryland Medical Center, Baltimore, MD, ³Surgery, University of Maryland Medical Center, Baltimore, MD
*Purpose: With the increasing number of ESRD patients requiring transplantation and stagnant number of deceased-donor organs available, minimizing the exclusion of living donor candidates with…
2019 American Transplant Congress
Long-term Impact of Antihypertensive Treatment and Tacrolimus Dose in Renal Allograft Recipients 5 Years Post-Transplantation
D. Rush¹, S. Cockfield², S. Wilson³, J. Schwartz⁴
¹University of Manitoba, Winnipeg, MB, Canada, ²University of Alberta Hopspital, Edmonton, AB, Canada, ³Astellas Pharma Global Development, Northbrook, IL, ⁴Astellas Pharma US, Northbrook, IL
*Purpose: Inflammation and fibrosis after renal transplantation may be modulated by optimizing tacrolimus exposure, or by use of angiotensin-converting enzyme inhibitors (ACEi), or angiotensin receptor…
2019 American Transplant Congress
Inflammation and Fibrosis Are Observed in 34% of Clinically Stable Adult Liver Transplant Recipients
L. Sun¹, J. Levitsky², S. Feng³, A. Humar⁴, A. J. Demetris⁴, J. Emond⁵, A. Shaked⁶, G. Klintmalm⁷, K. Mason⁸, M. DesMarais¹, A. Priore⁹, N. Bridges⁹, B. E. Burrell¹⁰, S. Chandran³, J. Markmann¹¹
¹ITN, San Francisco, CA, ²Northwestern, Chicago, IL, ³UCSF, San Francisco, CA, ⁴UPMC, Pittsburg, PA, ⁵Columbia, New York, NY, ⁶UPenn, Philadelphia, PA, ⁷Baylor, Dallas, TX, ⁸Rho, Chapel Hill, NC, ⁹NIAID, Bethesda, MD, ¹⁰ITN, Bethesda, MD, ¹¹MGH, Boston, MA
*Purpose: OPTIMAL is a 7-center immunosuppression withdrawal (ISW) study in non-autoimmune, non-HCV adult liver transplant recipients ≥3 yrs post-transplant (tx) (NCT02533180). Subjects underwent a screening…
2019 American Transplant Congress
Microscopic Hepatic Steatosis Prior to Liver Transplantation Influences Clinical Outcomes
K. Nakamura, H. Hirao, T. Ito, S. Kageyama, K. Kadono, K. J. Dery, J. Aziz, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski
Surgery, Liver Transplant, UCLA, Los Angeles, CA
*Purpose: Although liver transplantation (LT) has become a standard care for end-stage liver diseases, early allograft dysfunction (EAD) and rejection crises curtail the outcomes. Considering…