2016 American Transplant Congress » Poster Session D: Chimerism/Stem Cells, Cellular/Islet Transplantation, Innate Immunity, Chronic Rejection

Date: Tuesday, June 14, 2016

Time: 6:00pm-7:00pm

Location: Halls C&D

Session Type: Poster Session

Meeting: 2016 American Transplant Congress

6:00pm-7:00pm: In Vivo and In Vitro Characterization of 1.5 mm Ba²⁺-Alginate Macro-Encapsulated Cynomolgus Monkey Islets.

M. Bochenek,¹ J. McGarrigle,¹ J. Mendoza-Elias,¹ E. Marchese,¹ M. Nourmohammadzadeh,¹ Y. Wang,¹ A. Khan,¹ M. Omami,¹ C.-C. Yeh,¹ I. Lacik,² B. Strand,³ J. Oberholzer.¹

6:00pm-7:00pm: A Non-Hematopoietic Erythropoietin Analogue, ARA 290, Prolonged Allogeneic Pancreatic Islet Graft Survival in a Mouse Model.

M. Watanabe,¹ M. Yao,¹ D. Andersson,¹ M. Brines,² T. Lundgren,¹ M. Kumagai-Braesch.¹

6:00pm-7:00pm: A Novel Microfluidic Device for Purification of Pancreatic Islet Preparations.

W. Varhue,¹ L. Langman,² D. Bowers,³ S. Peirce-Cottler,³ N. Swami,¹ K. Brayman.²

6:00pm-7:00pm: A Novel, Non-Viral mRNA Delivery System for Targeted Protein Translation in Human Islets.

J. Oberholzer,^1,2 D. Gutierrez,^1,2 E. Marchese,¹ M. Nourmohammadzadeh,^1,2 Y. Wang.^1,2

6:00pm-7:00pm: Absence of Host CD137 Signaling Converts Chronic GVHD Toward Acute GVHD.

H. Cho,^1,3 J. Lee,^1,4 J. Kim,¹ U. Moon,¹ B. Kwon,^1,2 S. Park,³ K. Park.⁴

6:00pm-7:00pm: CD8⁺TCR^– Facilitating Cells in Mobilized Peripheral Blood Mononuclear Cells Are Enriched with IL-10 Producing B Cells.

Y. Wen, E. Yolcu, Y. Huang, L. Kahn, S. Ildstad.

6:00pm-7:00pm: Calcineurin Inhibitor (CNI) Nephrotoxicity Is Mediated by Defective Amp-Activated Protein Kinase (AMPK) Activation.

A. Zmijewska, J. Chen, J. Zmijewski, R. Mannon.

6:00pm-7:00pm: Chemokine Receptor CXCR4 Antagonist, a Novel Pathway to Prevent Chronic Allograft Nephropathy.

Y. Xu, Q. Zhang, X. Hu.

6:00pm-7:00pm: Chimeric Cell Transplantation for Treatment of Duchenne Muscular Dystrophy: A Preliminary Report.

E. Szilagyi, E. Bryndza Tfaily, J. Cwykiel, M. Siemionow.

6:00pm-7:00pm: Citrate-Based Thermoresponsive Hydrogel as a Versatile Platform for Extrahepatic Islet Transplantation.

Y. Zhu,¹ X. Zhang,² A. Guillermo,¹ X. Luo.²

6:00pm-7:00pm: Complement Receptor C5aR2 Deletion in Kidney Transplantation in Mice Attenuates Renal Damage.

A. Thorenz,¹ R. Chen,¹ K. Hueper,² B. Hensen,² C. Klemann,³ M. Meier,⁴ A. Klos,⁵ F. Gueler.¹

6:00pm-7:00pm: Contrasting Effects of Tacrolimus and Everolimus on Regulatory T Cell Activation and Mixed Hematopoietic Chimerism Induced by Natural Killer T Cell Stimulation.

S. Miyairi,^1,2 T. Hirai,¹ R. IShii,¹ M. Okumi,¹ Y. Ishii,³ S. Nunoda,² K. Yamazaki,² K. Tanabe.¹

6:00pm-7:00pm: Decellularized Rat Liver Scaffolds Support Multilineage Xenogenic and Heterogenic Cell Growth.

W. Hassanein, U. Dhru, J. Woodall, M. Uluer, A. Cimeno, D. Parsell, C. Rivera, S. Klepfer, C. Drachenberg, R. Barth, J. LaMattina.

6:00pm-7:00pm: Delaying the Induction of Mixed Chimerism Until Two Months After NHP Heart and Kidney Cotransplantation Results in Long Term Survival.

K. Huh,¹ M. Tonsho,¹ P. Spencer,¹ J. Paster,¹ X. Wu,¹ I. Hanekamp,¹ T. Kawai,^1,3 R. Smith,² A. Cosimi,¹ A. Dehnadi,¹ G. Benichou,¹ R. Colvin,^1,2 J. Madsen.^1,4

6:00pm-7:00pm: Dendritic Cells and Damage-Associated Molecular Patterns in Aging.

M. Seyda, H. Li, G. Liu, M. Quante, H. Uehara, J. Schuitenmaker, A. Elkhal, S. Tullius.

6:00pm-7:00pm: ESM1 Gene Promotes Hepatocyte Proliferation Through NF-κB Signal Pathway.

J. Zhou, W. Ju, X. Jiao, X. Zhu, X. He.

6:00pm-7:00pm: Establishment of SCID Pigs Cell Lines to Prevent Immunodeficiency Using RGEN System.

D.-H. Kim,¹ J.-S. Ahn,¹ S. Hwang,² J.-W. Lee.¹

6:00pm-7:00pm: Everolimus Abrogates C5a and TGFβ Mediated Perycite-to-Myofibroblast Transition (PMT) Inhibiting Vascular Rarefaction.

G. Castellano, R. Franzin, A. Stasi, C. Divella, L. Gesualdo.

6:00pm-7:00pm: FGF and Wnt Signaling in Pancreatic Progenitor and Beta-Cell Growth.

S. Afelik,¹ N. Yonan,¹ B. Pool,² J. Jensen,² J. Oberholzer.¹

6:00pm-7:00pm: HCK Is a Potential Mediator of Renal Fibrosis.

C. Wei,¹ M. Menon,¹ L. Li,² Z. Yi,¹ K. Keung,³ C. Woytovich,¹ I. Greene,¹ W. Zhang,¹ J. He,¹ B. Murphy.¹

6:00pm-7:00pm: High Resolution Detection of Human Pancreatic Islet Damage During and After Isolation Procedure Using MicroRNAs.

S. Prathab Balaji,¹ M. Kanak,² G. Yoshimatsu,¹ C. Chang,¹ M. Levy,² M. Lawrence,¹ P. Kim,³ N. Onaca,³ B. Naziruddin.³

6:00pm-7:00pm: Human Epineural Allograft Conduits Supported with Mesenchymal Stem Cells Enhance Peripheral Nerve Regeneration: A Preliminary Report.

M. Siemionow, M. Strojny, W. Malewski, J. Cwykiel, M. Cyran.

6:00pm-7:00pm: Human Multipotent Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact.

E. Montanari,¹ R. Meier,² D. Bosco,¹ R. Mahou,³ P. Morel,² J. Seebach,⁴ C. Wandrey,³ C. Gonelle-Gispert,¹ L. Bühler.²

6:00pm-7:00pm: Hydrogen Sulphide Is an Important Regulator of Erythropoietin Synthesis in Patients with Anemia of Chronic Kidney Disease.

J. Leigh,¹ P. Shao,¹ M. Saha,¹ I. Lobb,¹ A. Pasch,⁵ H. van Goor,⁴ M. Feelisch,² R. Wang,³ A. Sener.¹

6:00pm-7:00pm: IL-17A Preactivated Mesenchymal Stem Cells (MSC-17) Are Enriched for Genes Involved in T Cell Chemotaxis to Mediate Superior Immunosuppression.

K. Sivanathan,^1,2,3 D. Rojas-Canales,^1,2 S. Gronthos,⁴ S. Grey,⁵ P. Coates.^1,2,3

6:00pm-7:00pm: IgM Treatment Successfully Prevents Type 1 Diabetes by Dysregulation of Pancreatic MicroRNAs with Immunomodulatory Roles.

P. Chhabra, R. Gehrau, V. Mas, D. Bower, D. Maluf, K. Brayman.

6:00pm-7:00pm: Improved Regeneration of the Remnant Liver After Extended Hepatectomy or Partial Liver Transplantation by Pharmacologic Mobilization of Endogenous Stem Cells in Rats.

M. Chen, R. Zhai, L. Qi, A. Cameron, B. Philosophe, Z. Sun.

6:00pm-7:00pm: In Vitro and In Vivo Characterization of Human Hematopoietic Chimeric Cells – A Novel Approach for Tolerance Induction in Transplantation.

M. Siemionow, E. Tfaily, M. Cyran, R. Gendek, M. Strojny, E. Szilagyi, J. Cwykiel.

6:00pm-7:00pm: Inflammatory Conditions Switch the Effect of MSC on B Cells from Pro-Tolerogenic to Anti-Proliferative.

M. Franquesa,^1,2 F. Luk,¹ S. Korevaar,¹ L. Boon,³ F. Borras,² M. Betjes,¹ C. Baan,¹ M. Hoogduijn.¹

6:00pm-7:00pm: Mechanisms of Cellular Repopulation within Healthy or Intrinsically Scarred Kidney Extracellular Matrix Scaffolds.

J. Uzarski,¹ C. Deaton,⁵ H. Ward,² A. Wandinger-Ness,³ W. Miller,⁴ J. Wertheim.¹

6:00pm-7:00pm: MiRNA-200b Inhibits Epithelial-Mesenchymal Transition in TGF-β1 Induced Human Bronchial Epithelial Cells.

S. Ladak, C. Ward, S. Ali.

6:00pm-7:00pm: Monocyte Recruitment to HLA Class I Antibody-Activated Endothelial Cells Is Dependent Upon mTOR.

S. Salehi, E. Reed.

6:00pm-7:00pm: NFκB Inhibitor Withaferin A Blocks IBMIR In Vitro: miRNA 375 Analysis.

M. Kanak,¹ M. Takita,² G. Yoshimatsu,² M. Lawrence,² M. Levy,¹ B. Naziruddin.³

6:00pm-7:00pm: NKG2A-Expressing Natural Killer Cells Dominate the Response to Latent Epstein-Barr Virus Infection.

O. Hatton,¹ D. Strauss-Albee,² S. Krams,¹ C. Blish,² O. Martinez.¹

6:00pm-7:00pm: Natural Killer Cells Display Functional and Receptor Diversity in Response to Alloantigen.

O. Hatton,¹ T. Shawler,¹ C. Blish,² O. Martinez,¹ S. Krams.¹

6:00pm-7:00pm: Necroptosis Is Involved in CD4⁺ T-Cell Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection.

C. Kwok,^1,2 N. Montwill,^1,2 A. Pavlosky,^1,2 A. Haig,² X.-Y. Huang,¹ A. Jevnikar,^1,3 Z.-X. Zhang.^1,2,3

6:00pm-7:00pm: Novel Effect of miR-26a:Mdm2:p53 Pathway on Mouse Liver Regeneration.

J. Zhou, W. Ju, X. Yuan, X. Jiao, D. Wang, X. Zhu, X. He.

6:00pm-7:00pm: Novel Nuclear Factor-κB Activation Inhibitor, Dehydroxymethylepoxyquinomicin, Prevents the Development of Chronic Cyclosporine Nephropathy in Rats.

S. Morita,¹ K. Shinoda,¹ S. Tamaki,¹ H. Kono,² Y. Kanno,³ K. Umezawa,⁴ K. Nakagawa,² M. Oya.¹

6:00pm-7:00pm: Optimizing the Immunogenicity and Immunomodulatory Properties of MSC for Cellular Therapy.

S. de Witte,¹ M. Franquesa,¹ T. Strini,¹ S. Korevaar,¹ F. Luk,¹ S. Elliman,² P. Newsome,³ M. Gargesha,⁴ D. Roy,⁴ A. Merino,¹ C. Baan,¹ M. Hoogduijn.¹

6:00pm-7:00pm: Resveratrol Attenuates Liver IRI by Regulating Macrophage Activation Through SIRT1/p19/p53 Pathway.

K. Nakamura,¹ M. Zhang,² B. Ke,¹ S. Kageyama,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹

6:00pm-7:00pm: TNT009 and Its Parental Mouse Monoclonal Antibody TNT003 Target Complement Component C1s and Effectively Block Alloantibody-Induced Classical Complement Pathway Activation – The Preclinical Experience.

M. Wahrmann,¹ J. Mühlbacher,¹ H. Regele,¹ F. Eskandary,¹ J. Gilbert,² S. Panicker,² G. Böhmig.¹

6:00pm-7:00pm: Tacrolimus (Tac), Rather Than Cyclosporine (CsA), Interacts with Insulin Resistance (IR) to Alter Key Transcription Factors for β-Cell Identity & Function without Altering NFAT Localization.

J. Triñanes,¹ A. Rodriguez,² E. de Koning,¹ J. de Fijter,¹ F. Carlotti,¹ A. Torres,² A. de Vries,¹ E. Porrini.²

6:00pm-7:00pm: The Apoptosis of the Tracheal Epithelia Increase the Recipient's MSCs Derived Myofibroblasts in Allografts to Exacerbate Obliterative Bronchiolitis After Tracheal Transplantation in Mice.

C. Wang,¹ T. Xia,¹ X. Zhang,² K. Jiang,¹ J. Wang,¹ J. Nie.¹

6:00pm-7:00pm: The Function of CD8⁺TCR^– Facilitating Cells and Regulatory T Cells Is Impaired in Flt3-Ligand Knockout Mice.

Y. Huang, H. Xu, T. Miller, Y. Wen, S. Ildstad.

6:00pm-7:00pm: The IFN-Gamma-Inducible Protein (IP-10/CXCL10) Is a Promising Target to Improve Endocrine Function Following Islet Transplantation.

G. Yoshimatsu,¹ M. Kanak,² P. Balaji S,¹ C. Chang,³ C. Darden,³ M. Takita,¹ M. Lawrence,¹ B. Naziruddin.⁴

6:00pm-7:00pm: The Therapeutic Potential of Human Liver-Derived Stem Cell Transplantation in a Cirrhotic Liver Rat Model.

S. Lee,¹ J.-H. Lee,² H.-J. Park,² Y.-A. Kim,² M.-N. Park,² S.-K. Lee.¹

6:00pm-7:00pm: Thrombalexin: Detection & Efficacy of a Membrane-Bound Anti-Thrombin Agent.

M. Manook,^1,2 J. Kwun,¹ J. Yoon,¹ S. Sacks,² A. Dorling,² N. Mamode,² R. Smith,² S. Knechtle.¹

6:00pm-7:00pm: Tissue Priming of Plasmacytoid Dendritic Cells Enhances Their Phagocytosis and Lowers the Threshold for Subsequent Toll-Like Receptor 7/9 Activation.

J. Ruben,¹ G. Garcia-Romo,¹ E. Breman,¹ S. van der Kooij,¹ A. Redeker,² R. Arens,² C. van Kooten.¹

6:00pm-7:00pm: Tofacitinib Delivered by Solid Lipid Nanoparticles Inhibits Dendritic Cell Maturation and Their Allostimulatory Capacity.

J. Budihardjo,¹ M. Iglesias,¹ J. Walch,¹ X. Calderon-Colon,² W. Lee,¹ G. Brandacher,¹ J. Patrone,² G. Raimondi.¹

6:00pm-7:00pm: Transplantation of Islet Preconditioned with Hydrogen Sulfide Enhances the Graft Function in Diabetic Mice.

D. Wang, M. Ding, J. Xue, J. Zheng, S. Feng, H. Tian, Y. Li.

6:00pm-7:00pm: aPC Pretreatment of hEPCR-Expressing PAECs Attenuates Endothelial Cell Damage and Thrombosis.

C. Laird,¹ B. French,¹ D. Harris,¹ X. Chang,¹ D. Ayares,² R. Pierson,¹ A. Azimzadeh.¹

6:00pm-7:00pm: c-Kit⁺ Cells Are Kidney-Specific Progenitor/Stem Cells with Regenerative Potential.

S. Abreu Gomes,¹ G. Goss,² B. Goldstein,² B. Seidler,³ D. Saur,³ J. Hare,² E. Bevilaqua Rangel.¹

6:00pm-7:00pm: iNKT Cell Ligands Administered with Bone Marrow Cells Expand Allo-Specific Regulatory T Cells In Vivo and Establish Transplant Tolerance.

S. Miyairi,^1,2 T. Hirai,¹ M. Okumi,¹ Y. Ishii,³ K. Yamazaki,² K. Tanabe.¹

« View all sessions from the 2016 American Transplant Congress