ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell activation"

  • 2020 American Transplant Congress

    Autophagy-Lysosome Inhibitor Chloroquine Prevents CTLA-4 Degradation of T Cells and Attenuates Acute Rejection in Murine Skin and Heart Transplantation

    J. Wu

    Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    *Purpose: The immune checkpoint cytotoxic T lymphocyte antigen-4 (CTLA-4), which was induced upon T cell activation but degraded quickly, has been targeted in the clinical…
  • 2020 American Transplant Congress

    T Cell Hyporesponsiveness in Kidney Transplant Recipients is Associated with Urinary Tract Infections and Age of Kidney Transplant: Implications for Allograft Nephropathy

    A. Assounga, S. Omarjee

    Dept of Nephrology, University of KwaZulu-Natal, Durban, South Africa

    *Purpose: Chronic allograft nephropathy is the main cause of kidney graft loss. With the use of potent immunosuppressive treatments, acute rejections are less and less…
  • 2020 American Transplant Congress

    Notch Signaling Inhibition via Blockade of Delta-Like Ligand 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection

    A. J. Matar, B. P. Lovasik, Y. Dong, D. A. Faber, J. Habib, C. A. Breeden, J. Regenold, A. Ghosh, A. Stephenson, W. H. Kitchens, A. B. Adams

    Surgery and Transplantation, Emory University, Atlanta, GA

    *Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of Belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…
  • 2020 American Transplant Congress

    Efficacy of Photobiomodulation Therapy Combined with Short-Term Immunosuppressants Prolonged Allotransplant Survival in a Rodent Hind-Limb Model

    Y. Kuo1, C. Chen2, R. Chen2, Y. Li2

    1Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, 2Division of Plastic Surgery, Department of Surgery,, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

    *Purpose: Photobiomodulation has been applied for accelerating the skeletal muscle repair process. Our formal study demonstrated vitamin D could be involved in allograft survival and…
  • 2020 American Transplant Congress

    Mitochondrion-Endothelial Interaction Generates Danger Signal in Promoting Costimulation-Resistant T Cell-Mediated Allograft Rejection

    S. Li1, M. Song1, Q. Li2, A. Kirk1, H. Xu1

    1Surgery, Duke University, Durham, NC, 2Immunology, Duke University, Durham, NC

    *Purpose: Endothelial cells (ECs) play a critical role in allorecognition, presentation, and costimulation for initiation of alloimmune rejection. The objective of this study was to…
  • 2020 American Transplant Congress

    Ischemic and Perfused Kidney Treated with Non-Cultured Adipose-Derived Regenerative Cells Increase the Immune and Regulatory Transcriptome

    R. Lathan1, R. Ghita1, R. Touyz1, M. Clancy2, P. Mark1

    1Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom, 2Renal Transplant Unit, Queen Elizabeth University Hospital, Glasgow, United Kingdom

    *Purpose: Studies in our rat model of ischemic reperfusion injury (IRI) demonstrate improved kidney function post injection of non-cultured autologous adipose-derived regenerative cells (ADRC). The…
  • 2020 American Transplant Congress

    Costimulatory Signal Impacts Car Treg Fate and Function in Transplantation

    B. Lamarthée1, A. Marchal1, S. Charbonnier1, T. Blein1, K. Vogt2, M. Titeux1, N. Pallet3, M. Delville1, E. Six1, D. Anglicheau4, C. Legendre4, B. Sawitzki2, J. Taupin5, M. Cavazzana1, I. André1, J. Zuber1

    1Inserm U1163, Institut Imagine, Paris, France, 2Department of Immunology, Charité University Hospital, Berlin, Germany, 3Inserm U1147, Centre Universitaire des Saints Pères, Paris, France, 4Service de Transplantation Rénale Adulte, Assistance Publique–Hôpitaux de Paris, Hôpital Necker, Paris, France, 5Inserm U1160, Centre Hayem, Paris, France

    *Purpose: Donor-specific regulatory T-cell (Treg) therapy has emerged as a potent strategy to promote immune tolerance in experimental transplantation. However, a major stumbling block in…
  • 2020 American Transplant Congress

    Impact of PD1, PDL1 Gene Polymorphisms on Allo-Immune Responses after Kidney Transplantation

    H. Yamane, Y. Tanaka, M. Ohira, H. Tahara, K. Ide, H. Ohdan

    Hiroshima University, Hiroshima, Japan

    *Purpose: The programmed death (PD)-1/PD-1 ligands (PD-Ls) pathway, a member of the B7/CD28 family, triggers an immune checkpoint resulting in inhibition of T cells. Several…
  • 2020 American Transplant Congress

    Pretransplant BKV-IgG Serostatus and BKV-Specific ELISPOT Assays for the Prediction of BKV Infection

    H. Bae1, J. Jang1, H. Lee2, S. Yun1, E. Oh3

    1Department of Biomedical Science, Graduate School, Catholic University of Korea, Seoul 137-040, Korea, Republic of, 2Department of Laboratory Medicine, Catholic Kwandong University of Korea, Incheon, Korea, Republic of, 3Department of Laboratory Medicine, Catholic University of Korea, Seoul 137-040, Korea, Republic of

    *Purpose: BK Polyomavirus (BK) can lead to major infectious complications and damage to the graft in kidney transplantation (KT). We investigated whether pretransplant BK serostatus…
  • 2020 American Transplant Congress

    Neuropilin 2 is a Novel Coinhibitory Molecule That Suppresses Alloimmune Responses Following Transplantation

    J. Wedel, J. Lee, N. Kochupurakkal, E. Chernov, M. Poreddy, K. Liu, S. Kong, D. Bielenberg, H. Nakayama, D. M. Briscoe

    Boston Children's Hospital, Boston, MA

    *Purpose: We have previously reported that signaling via the transmembrane receptor neuropilin 2 (NRP2) regulates PI3K/mTOR/Akt activity in several human cell lines. Furthermore, it is…
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