2020 American Transplant Congress
B Cell Depletion with Anti-CD20 mAb Exacerbates Anti-Donor CD4+ T Cell Responses in Highly Sensitized Transplant Model
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: Preformed donor-specific anti-human leukocyte antigen antibodies (DSAs) have been associated with detrimental effects in transplant recipients. To eliminate preformed DSAs, we desensitized DSA-positive recipients…2020 American Transplant Congress
CD11b is a Novel Alternate Receptor for CD154 During Alloimmunity
*Purpose: For decades, blockade of CD40-CD154 has been shown to be a highly effective means of inhibiting alloreactive T cell responses and inducing long-term graft…2020 American Transplant Congress
Hemodialysis (HD) Treatment Associates with Increased Risk of Delayed Graft Function (DGF) after Renal Transplantation (RT) and Augmented Cd4 and Cd8 T Cell Proliferation Compared to Peritoneal Dialysis (PD)
*Purpose: Delayed graft function (DGF) is a common event after RT that increases the risk of acute rejection and early graft loss. The impact of…2020 American Transplant Congress
Interferon-Beta Acts Directly on T Cells to Promote Foxp3 Acetylation in Regulatory T Cells
Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Interferon-β (IFNβ) is a type I interferon that binds to its receptor (IFNAR) expressed on immune cells. It has known antiviral and pro-inflammatory activity…2020 American Transplant Congress
Torc1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: The use of Regulatory T cells (Tregs) in adoptive cell therapy has been hindered by their short survival following their adoptive transfer. We have…2020 American Transplant Congress
Immuno-Modulation of Primed Xenogeneic T Cell Response by mTOR Blockade of T Cells and Porcine Endothelial Cells
Surgery, Duke University, Durham, NC
*Purpose: Porcine vascular endothelial cells (PECs) play a central role in xeno-recognition and costimulation. The objectives of this study were to characterize the immuno-phenotype of…2020 American Transplant Congress
Unique Genomic & Proteomic Profile of Liver Mesenchymal Stromal Cells is Associated with Their Superior Immunomodulatory Properties
Transplant Center, Mayo Clinic, Rochester, MN
*Purpose: Investigating mechanisms of liver allografts’ relative tolerance, we recently reported that liver mesenchymal stromal cells (L-MSC) are superior in their capacity to inhibit alloimmune…2020 American Transplant Congress
Is it Time for Immune Screening for Belatacept-Treated Stable Kidney Transplant Patients for Adjust the Immunosuppression?
1ITAC, Buenos Aires, Argentina, 2CEFYBO, UBA, Buenos Aires, Argentina
*Purpose: Belatacept is a co-stimulation blocker for primary maintenance immunosuppression in kidney transplant recipients. The goal of this work was to study the immunological status…2020 American Transplant Congress
Effector Differentiation of Endogenous Antigen-Specific CD8+ T Cells is Selectively Limited by CTLA-4 Ig
Emory Transplant Center, Emory University School of Medicine, Atlanta, GA
*Purpose: Costimulation blockade with belatacept (CTLA-4 Ig) offers improved renal function and reduced toxicity following transplantation compared to calcineurin inhibitors. Nonetheless, episodes of acute T…2020 American Transplant Congress
Lateral Flow Assay to Detect Soluble CD25 after Kidney Transplantation
Faculty of Natural Sciences, Institute of Technical Chemistry, Hannover, Germany
*Purpose: Kidney transplantations are one of the most common transplantations in the world; 80.696 kidneys were transplanted in 2017. Despite tremendous improvements in quality and…
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