ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell activation"

  • 2020 American Transplant Congress

    Torc1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B

    J. B. Alhaddad, H. Allos, B. S. Al Dulaijan,, S. K. Eskandari, I. Sulkaj, G. Melhem, J. Y. Choi, J. R. Azzi

    Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    *Purpose: The use of Regulatory T cells (Tregs) in adoptive cell therapy has been hindered by their short survival following their adoptive transfer. We have…
  • 2020 American Transplant Congress

    Immuno-Modulation of Primed Xenogeneic T Cell Response by mTOR Blockade of T Cells and Porcine Endothelial Cells

    S. Li, A. Kirk, H. Xu

    Surgery, Duke University, Durham, NC

    *Purpose: Porcine vascular endothelial cells (PECs) play a central role in xeno-recognition and costimulation. The objectives of this study were to characterize the immuno-phenotype of…
  • 2020 American Transplant Congress

    Unique Genomic & Proteomic Profile of Liver Mesenchymal Stromal Cells is Associated with Their Superior Immunomodulatory Properties

    F. Yigitbilek, W. D. Park, N. Abrol, M. D. Stegall, T. Taner

    Transplant Center, Mayo Clinic, Rochester, MN

    *Purpose: Investigating mechanisms of liver allografts’ relative tolerance, we recently reported that liver mesenchymal stromal cells (L-MSC) are superior in their capacity to inhibit alloimmune…
  • 2020 American Transplant Congress

    Is it Time for Immune Screening for Belatacept-Treated Stable Kidney Transplant Patients for Adjust the Immunosuppression?

    M. C. Rial1, F. Caro2, N. Ambrosi2, D. Guerrieri2, A. Calleri1, E. Chuluyan1, D. Casadei1

    1ITAC, Buenos Aires, Argentina, 2CEFYBO, UBA, Buenos Aires, Argentina

    *Purpose: Belatacept is a co-stimulation blocker for primary maintenance immunosuppression in kidney transplant recipients. The goal of this work was to study the immunological status…
  • 2020 American Transplant Congress

    Effector Differentiation of Endogenous Antigen-Specific CD8+ T Cells is Selectively Limited by CTLA-4 Ig

    S. M. Krummey, K. P. Tong, M. L. Ford

    Emory Transplant Center, Emory University School of Medicine, Atlanta, GA

    *Purpose: Costimulation blockade with belatacept (CTLA-4 Ig) offers improved renal function and reduced toxicity following transplantation compared to calcineurin inhibitors. Nonetheless, episodes of acute T…
  • 2020 American Transplant Congress

    Peripheral Blood RNA Sequencing Unravels a Differential Role of Coding and Non-Coding Genes by Types of Kidney Allograft Rejection

    S. Sur1, S. Pineda1, T. Sigdel1, M. Sirota1, O. Bestard2, M. Sarwal1

    1University of California San Francisco, San Francisco, CA, 2Laboratory of Experimental Nephrology and Transplantation, Barcelona, Spain

    *Purpose: Peripheral blood molecular patterns characterizing the different effector immune pathways driving kidney allograft rejection remain to be fully completely elucidated, to more fully type…
  • 2020 American Transplant Congress

    Lateral Flow Assay to Detect Soluble CD25 after Kidney Transplantation

    L. K. Seiler, C. Blume, R. Jonczyk

    Faculty of Natural Sciences, Institute of Technical Chemistry, Hannover, Germany

    *Purpose: Kidney transplantations are one of the most common transplantations in the world; 80.696 kidneys were transplanted in 2017. Despite tremendous improvements in quality and…
  • 2020 American Transplant Congress

    Autophagy-Lysosome Inhibitor Chloroquine Prevents CTLA-4 Degradation of T Cells and Attenuates Acute Rejection in Murine Skin and Heart Transplantation

    J. Wu

    Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    *Purpose: The immune checkpoint cytotoxic T lymphocyte antigen-4 (CTLA-4), which was induced upon T cell activation but degraded quickly, has been targeted in the clinical…
  • 2020 American Transplant Congress

    Hemodialysis (HD) Treatment Associates with Increased Risk of Delayed Graft Function (DGF) after Renal Transplantation (RT) and Augmented Cd4 and Cd8 T Cell Proliferation Compared to Peritoneal Dialysis (PD)

    A. Angeletti1, C. Donadei1, G. Donati1, G. Di Certo1, D. Conte1, L. Gasperoni1, E. Pelizzaro1, C. Guglielmo1, G. Comai1, P. Cravedi2, G. La Manna1

    1DIMES, S.Orsola-Malpighi Hospital, Bologna University, Bologna, Italy, 2DIMES, Icahn School of Medicine at Mount Sinai, New York, NY, US, New York, NY

    *Purpose: Delayed graft function (DGF) is a common event after RT that increases the risk of acute rejection and early graft loss. The impact of…
  • 2020 American Transplant Congress

    Notch Signaling Inhibition via Blockade of Delta-Like Ligand 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection

    A. J. Matar, B. P. Lovasik, Y. Dong, D. A. Faber, J. Habib, C. A. Breeden, J. Regenold, A. Ghosh, A. Stephenson, W. H. Kitchens, A. B. Adams

    Surgery and Transplantation, Emory University, Atlanta, GA

    *Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of Belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…
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