2020 American Transplant Congress
Neuropilin 2 is a Novel Coinhibitory Molecule That Suppresses Alloimmune Responses Following Transplantation
Boston Children's Hospital, Boston, MA
*Purpose: We have previously reported that signaling via the transmembrane receptor neuropilin 2 (NRP2) regulates PI3K/mTOR/Akt activity in several human cell lines. Furthermore, it is…2020 American Transplant Congress
Regulatory T Cells Engineered with TCR-Signaling-Responsive Il-2 Nanogels Suppress Alloimmunity in Sites of Antigen Encounter
*Purpose:2020 American Transplant Congress
Modulating ITK Signaling Facilitate Allogeneic Skin Engraftment and Clear LCMV Viruses by Regulating IRF-4, JAK STAT and Eomes Expression
*Purpose:Solid organ transplantation is a life-saving procedure to treat end-stage organ failure. However, transplantation of organs between genetically distinct individuals results in acute graft rejection…2020 American Transplant Congress
CD11b is a Novel Alternate Receptor for CD154 During Alloimmunity
*Purpose: For decades, blockade of CD40-CD154 has been shown to be a highly effective means of inhibiting alloreactive T cell responses and inducing long-term graft…2020 American Transplant Congress
Chronic Kidney Disease Alters the T Cell Response to Murine Cytomegalovirus
*Purpose: We have previously reported that patients with chronic kidney disease (CKD) accumulate memory T cells bearing markers of sustained antigen stimulation and enhanced pro-inflammatory…2020 American Transplant Congress
Interferon-Beta Acts Directly on T Cells to Promote Foxp3 Acetylation in Regulatory T Cells
Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Interferon-β (IFNβ) is a type I interferon that binds to its receptor (IFNAR) expressed on immune cells. It has known antiviral and pro-inflammatory activity…2020 American Transplant Congress
B Cell Depletion with Anti-CD20 mAb Exacerbates Anti-Donor CD4+ T Cell Responses in Highly Sensitized Transplant Model
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: Preformed donor-specific anti-human leukocyte antigen antibodies (DSAs) have been associated with detrimental effects in transplant recipients. To eliminate preformed DSAs, we desensitized DSA-positive recipients…2019 American Transplant Congress
Single Nucleotide Polymorphisms in NFACT1 rs2290154 Associated with the Risk of T Cell-Mediated Rejection of Recipients Following Kidney Transplantation
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: Our study was to investigate the potential associations between the single nucleotide polymorphisms (SNPs) in NFATC1 and the risk of T cell-mediated rejection (TCMR)…2019 American Transplant Congress
IFNAR Signaling Augments Plasmacytoid Dendritic Cell Activation during Costimulation Independent Rejection
Surgery, Emory University, Atlanta, GA
*Purpose: Costimulation blockade (CoB) is a promising new transplant immunosuppression strategy offering improved long-term patient and allograft survival without the nephrotoxicity of calcineurin inhibitors. However,…2019 American Transplant Congress
Type-1 Interferons Impair the Key Immunoregulatory Activity of IL-10 in the Promotion of Transplant Tolerance
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) regimens is impaired by inflammatory responses. Despite the identification of type-1 interferons (TI-IFN) as…
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