ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell activation"

  • 2021 American Transplant Congress

    T-Cell Responses in Solid Organ Transplant Recipients with SARS-CoV-2 Infection

    V. H. Ferreira, T. M. Marinelli, T. Ku, M. Ierullo, B. Majchrzak-Kita, I. Bahinskaya, N. Pinzon, A. Humar, D. Kumar

    University Health Network, Toronto, ON, Canada

    *Purpose: Preliminary data suggest solid organ transplant (SOT) recipients may be at high-risk for developing severe COVID-19. This may be due in part to alterations…
  • 2021 American Transplant Congress

    P2X7 Receptor Activity Mediates Th17-Specific Self- and Alloreactivity in Non-Human Primates

    C. Little, J. Sullivan, W. Burlingham, D. Kaufman

    Department of Surgery, University of Wisconsin, Madison, WI

    *Purpose: The broadly expressed ATP-binding purinergic receptor, P2X7 (P2X7R) is involved in the Th17 mediated cellular immune response to allo- and select self-antigens (Collagen type…
  • 2021 American Transplant Congress

    Reassessing TCMR in Kidney Transplant Indication Biopsies: Emerging Evidence for Partial Exhaustion in Late TCMR

    P. Halloran1, J. Reeve1, &. the INTERCOMEX Study Group2

    1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2., ., AB, Canada

    *Purpose: We rederived the MMDx rejection archetypes in an expanded set of 1679 kidney transplant biopsies to add power and potentially define heterogeneity in TCMR.…
  • 2021 American Transplant Congress

    Establishing a Linear Program for the Development of Costimulation Resistant T-Cells

    D. P. Moris, A. Lucander, A. Kirk

    Surgery, Duke, Durham, NC

    *Purpose: CD4+CD57+PD1-T-cells are primed effectors capable of mediating belatacept-resistant rejection, however, the developmental program giving rise to these cells has not been elucidated in detail.…
  • 2021 American Transplant Congress

    A Mechanistic Evaluation to Guide the Optimal Immunosuppression Adjustment Strategy in Transplant Patients with COVID-19

    V. Hall, V. Ferreira, D. Kumar, A. Humar

    UHN, Toronto, ON, Canada

    *Purpose: The optimal management of immunosuppression in transplant patients infected with COVID-19 is unknown. Reduction in calcineurin inhibitors or antimetabolite doses is often performed in…
  • 2021 American Transplant Congress

    CRISPR Screens to Map CTLA-4 Regulatory Networks in Primary Human T Cells

    O. Shaked1, J. Freimer1, J. Pritchard2, A. Marson1

    1UCSF, San Francisco, CA, 2Stanford University, Stanford, CA

    *Purpose: For most cell types, the pathways that regulate the levels of critical disease-relevant genes are not known. Recent advances in gene editing have enabled…
  • 2021 American Transplant Congress

    Effect of HLA Class II Polymorphism on Predicted Cellular Immunity Against SARS-CoV-2 at the Individual Level and Within Twenty Five Race/ethnic Groups

    H. C. Copley1, L. Gragert2, A. R. Leach3, V. Kosmoliaptsis1

    1Department of Surgery, University of Cambridge, Cambridge, United Kingdom, 2Department of Pathology, Tulane University School of Medicine, New Orleans, LA, 3European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom

    *Purpose: Development of adaptive immunity after COVID-19 and after vaccination against SARS-CoV-2 is predicated on recognition of viral peptides, presented on HLA class II molecules,…
  • 2021 American Transplant Congress

    Dna-pkcs Regulation of the Allogeneic Immune Response

    L. Burdine, M. Burdine, Z. Waldrip, D. Harrison

    University of Arkansas, Little Rock, AR

    *Purpose: Organ transplantation is life-saving and continued investigations into immunological mechanisms that drive organ rejection are needed to improve immunosuppression therapies and prevent graft failure.…
  • 2021 American Transplant Congress

    Detection of SARS-CoV-2 Specific Functional T Cells Using a Seven Color Flow Cytometry Assay

    L. Flebbe-Rehwaldt, J. Hayden, K. Mickey, S. Manley, S. Kleiboeker

    Eurofins-Viracor, Lees Summit, MO

    *Purpose: The need to evaluate SARS-CoV-2 immune responses is an important clinical research focus. Detecting neutralizing antibodies is one measure of immune response, but the…
  • 2021 American Transplant Congress

    Impaired Antibody Responses to Spike Protein Antigens of Sars-cov-2 in Solid Organ Transplant (sot) Recipients

    C. Ashokkumar1, S. Nadig2, V. Rohan2, A. Kroemer3, H. Dhani3, S. Rao4, R. Sindhi5

    1Plexision, pittsburgh, PA, 2Medical University of South Carolina, Charleston, SC, 3MedStar Georgetown Transplant Institute, Georgetown, DC, 4DHR Health Institute for Research and Development, Texas, TX, 5University of Pittsburgh, Pittsburgh, PA

    *Purpose: Chronic immunosuppression can impair antibody responses after natural infection and vaccination in SOT recipients. It is not known whether antibody responses are impaired in…
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