ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell activation"

  • 2022 American Transplant Congress

    Novel Immune Checkpoint Molecule TIGIT Mediates Experimental Kidney Ischemia Reperfusion Injury

    S. Noel, K. Lee, S. Gharaie, J. T. Kurzhagen, H. Rabb

    Medicine, Johns Hopkins University, Baltimore, MD

    *Purpose: T cells play both pathogenic and reparative roles in kidney ischemia reperfusion injury (IRI) but the molecular mechanisms regulating kidney T cell functions are…
  • 2022 American Transplant Congress

    Neuropilin-2 is a Novel Checkpoint Inhibitor That is Required for Long-Term Allograft Survival

    J. Wedel, S. Kong, K. Liu, N. Kochupurakkal, D. Bala, D. Bielenberg, H. Nakayama, D. M. Briscoe

    Boston Children's Hospital, Boston, MA

    *Purpose: We have previously reported that Neuropilin (NRP) 2-associated signaling events modulate PI3K/mTOR/Akt activity in several human cell lines. While intrinsic NRP1 activity has been…
  • 2022 American Transplant Congress

    T Cell Overexpression of PD-1 Increases Treg Suppressive Function via an ICOS-Dependent Mechanism

    T. J. Borges1, N. Murakami2, I. T. Lape1, R. B. Gassen1, K. Liu1, L. V. Riella1

    1Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Transplantation Research Center, Brigham and Women's Hospital, Boston, MA

    *Purpose: The PD-1: PD-L1 signaling has inhibitory properties and is a potential therapeutic target in transplantation. We have previously demonstrated that overexpression of PD-1 on…
  • 2022 American Transplant Congress

    Optimal Development and Effector Function of Antibody-Suppressor CXCR5+CD8+ T Cells Requires Host IFN-γ and CD4+ T Cells

    J. Zimmerer, S. Chaudhari, M. Hart, J. Han, K. Koneru, G. Bumgardner

    OSUWMC, Columbus, OH

    *Purpose: We reported the discovery of a novel subset of CXCR5+IFNγ+CD8+ T cells that suppresses antibody production (CD8+ TAb-supp cells). Alloprimed CD8+ TAb-supp cells significantly…
  • 2022 American Transplant Congress

    Single-Cell RNA Sequencing Identifies the Changes of Human Normal Kidney After Transplantation

    G. Huang1, H. Zhang1, X. Chen1, G. Zhao1, J. Luo1, S. Yang2, J. Qiu1

    1Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China, 2Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

    *Purpose: We found that in all studies about kidney transplantation and single cell RNA sequencing (scRNA-seq), the native kidney rather than the transplanted kidney was…
  • 2022 American Transplant Congress

    The Role of T Lymphocyte Subsets in Kidney Transplantation

    L. Vagiotas1, A. Xochelli2, E. Sampani3, V. Nikolaidou2, D. Asouchidou2, E. Kasimatis3, N. Antoniadis1, M. Daoudaki4, M. Stangou3, A. Papagianni3, G. Tsoulfas1, A. Fylaktou2

    1Division of Organ Transplantation, Department of Surgery, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, 2National Peripheral Histocompatibility Center, Immunology Department, Hippokration Hospital, Thessaloniki, Greece, 3Department of Nephrology, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, 4Laboratory of Biological Chemistry, Faculty of Medicine Aristotle University of Thessaloniki, Thessaloniki, Greece

    *Purpose: Impairment of cellular immune function in kidney transplant candidates is not concomitantly restored with the recovery of renal function, as alloimmune response and implementation…
  • 2021 American Transplant Congress

    A Mechanistic Evaluation to Guide the Optimal Immunosuppression Adjustment Strategy in Transplant Patients with COVID-19

    V. Hall, V. Ferreira, D. Kumar, A. Humar

    UHN, Toronto, ON, Canada

    *Purpose: The optimal management of immunosuppression in transplant patients infected with COVID-19 is unknown. Reduction in calcineurin inhibitors or antimetabolite doses is often performed in…
  • 2021 American Transplant Congress

    CRISPR Screens to Map CTLA-4 Regulatory Networks in Primary Human T Cells

    O. Shaked1, J. Freimer1, J. Pritchard2, A. Marson1

    1UCSF, San Francisco, CA, 2Stanford University, Stanford, CA

    *Purpose: For most cell types, the pathways that regulate the levels of critical disease-relevant genes are not known. Recent advances in gene editing have enabled…
  • 2021 American Transplant Congress

    Effect of HLA Class II Polymorphism on Predicted Cellular Immunity Against SARS-CoV-2 at the Individual Level and Within Twenty Five Race/ethnic Groups

    H. C. Copley1, L. Gragert2, A. R. Leach3, V. Kosmoliaptsis1

    1Department of Surgery, University of Cambridge, Cambridge, United Kingdom, 2Department of Pathology, Tulane University School of Medicine, New Orleans, LA, 3European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom

    *Purpose: Development of adaptive immunity after COVID-19 and after vaccination against SARS-CoV-2 is predicated on recognition of viral peptides, presented on HLA class II molecules,…
  • 2021 American Transplant Congress

    Dna-pkcs Regulation of the Allogeneic Immune Response

    L. Burdine, M. Burdine, Z. Waldrip, D. Harrison

    University of Arkansas, Little Rock, AR

    *Purpose: Organ transplantation is life-saving and continued investigations into immunological mechanisms that drive organ rejection are needed to improve immunosuppression therapies and prevent graft failure.…
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