ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell activation"

  • 2022 American Transplant Congress

    Toll-Like Receptor-4 Inhibitor, Resatorvid, Attenuates Allogenic T Cell Activation Against Human Pancreatic Islets by Decreasing CD69 Expression

    J. Mattke1, M. Plunk1, R. R. Kane1, B. Naziruddin2

    1Baylor University, Waco, TX, 2Baylor University Medical Ctr, Dallas, TX

    *Purpose: Allogenic and autoimmune response against islets remain major obstacles to improve long term function of islet transplants. Inhibition of toll-like receptor 4 (TLR4) using…
  • 2022 American Transplant Congress

    A Low Immuknow Level but Behold….pAMR1(H+) Rejection

    M. W. Weston

    Tampa General Hospital, Tampa, FL

    *Purpose: PURPOSE: The purpose of this study is to evaluate the mechanism of pAMR1(H+) rejection in heart transplant recipients with low ImmuKnow levels (ATP
  • 2022 American Transplant Congress

    Antibody Response and Cellular Phenotyping in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination

    N. M. Ali1, J. Miles2, S. Mehta1, V. Tatapudi1, B. Lonze1, E. Weldon1, Z. Stewart1, C. DiMaggio1, J. Allen3, S. Gray-Gaillard3, S. Solis3, M. Tuen3, J. Leonard1, R. Montgomery1, R. Herati3

    1Transplant Institute, NYU Langone Health, New York, NY, 2CareDx, Brisbane, NY, 3NYU Langone Health, New York, NY

    *Purpose: Correlates of protection for SARS-CoV-2 vaccines are not well-established in kidney transplant recipients(KTRs). Studies have highlighted the importance of neutralizing antibodies(Abs), however data suggests…
  • 2022 American Transplant Congress

    Assessment of Humoral and Cellular Immune Responses to Sars Cov-2 Vaccination in Immunocompromised Renal Allograft Recipients

    B. Shin, R. Zhang, T. M. Gadsden, A. Petrosyan, A. Vo, N. Ammerman, S. Sethi, E. Huang, A. Peng, R. Najjar, J. Atienza, I. Kim, S. C. Jordan

    Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: SARS CoV-2 vaccination elicits both robust humoral and T-cell immune responses in healthy individuals. However, a comprehensive assessment of immune responses to SARS-CoV-2 vaccination…
  • 2022 American Transplant Congress

    Novel Immune Checkpoint Molecule TIGIT Mediates Experimental Kidney Ischemia Reperfusion Injury

    S. Noel, K. Lee, S. Gharaie, J. T. Kurzhagen, H. Rabb

    Medicine, Johns Hopkins University, Baltimore, MD

    *Purpose: T cells play both pathogenic and reparative roles in kidney ischemia reperfusion injury (IRI) but the molecular mechanisms regulating kidney T cell functions are…
  • 2022 American Transplant Congress

    Neuropilin-2 is a Novel Checkpoint Inhibitor That is Required for Long-Term Allograft Survival

    J. Wedel, S. Kong, K. Liu, N. Kochupurakkal, D. Bala, D. Bielenberg, H. Nakayama, D. M. Briscoe

    Boston Children's Hospital, Boston, MA

    *Purpose: We have previously reported that Neuropilin (NRP) 2-associated signaling events modulate PI3K/mTOR/Akt activity in several human cell lines. While intrinsic NRP1 activity has been…
  • 2021 American Transplant Congress

    Polyfunctional T-cell Impairment to Sars-cov-2 Coronavirus in Solid Organ Transplant Recipients with Acute Covid-19 Infection

    A. Favà1, L. Donadeu2, V. Pernin3, M. Meneghini1, E. Crespo2, N. Sabé4, L. Lladó5, J. Gonzalez-Costello6, O. Thaunat7, O. Bestard1

    1Kidney Transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, 2Experimental Nephrology Laboratory, IDIBELL, Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, 3Kidney Transplant Unit, Hospital de Montpellier, Montpellier, France, 4Infectious Disease Department, Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, 5Liver Transplant Unit, Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, 6Heart Transplantation Unit, Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, 7Department of Transplantation, Edouard Herriot Hospital Lyon, Lyon, France

    *Purpose: The emerged COVID-19 pandemic caused by SARS-CoV-2 has paralyzed the world, due to its high infectivity and fatal outcomes, especially among more vulnerable individuals.…
  • 2021 American Transplant Congress

    IL-10 Signaling in T Cells Modulates Costimulation-independent Activation and is Essential for Transplant Tolerance Induction

    M. Iglesias Lozano1, D. Bibicheff1, M. Chicco2, A. Komin1, G. Brandacher1, G. Raimondi1

    1Plastic Surgery, Johns Hopkins University, Baltimore, MD, 2Frimley Health NHS Foundation Trust, London, United Kingdom

    *Purpose: Costimulation blockade (CoB)-based immunotherapy remains a very promising approach for better management of transplant recipients. Understanding the mechanisms that impact the efficacy of CoB…
  • 2021 American Transplant Congress

    Role of Baseline PD-1 Checkpoint Inhibitor Pathway Expression in Bridge to Liver Transplant Hepatocellular Carcinoma

    K. Nunez, T. Sandow, M. Hibino, A. Cohen, P. Thevenot

    Ochsner Health, New Orleans, LA

    *Purpose: Response to first line liver-directed therapy (LDT) in hepatocellular carcinoma (HCC) has important implications in both bridge to transplant (BTT) success as well as…
  • 2021 American Transplant Congress

    Evaluation of the Differentiation Program of Endogenous Antigen-specific CD8+T Cells Following Transplantation

    S. M. Krummey1, K. Tong2, M. L. Ford2

    1Pathology, Johns Hopkins University, Baltimore, MD, 2Surgery, Emory Transplant Center, Atlanta, GA

    *Purpose: Despite advances in the survival of transplanted organs, acute T cell mediated rejection remains a significant clinical problem with few effective or targeted treatments.…
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