Articles tagged "Rat"

2019 American Transplant Congress
CD38 Inhibition: A Novel Target for Hepatic Ischemia Reperfusion Injury
C. Akateh¹, B. F. Reader¹, Y. Lee¹, J. Kim¹, K. Maynard¹, K. W. Washburn¹, J. L. Zweier², B. A. Whitson¹, S. M. Black¹
¹Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, ²The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Ischemia/reperfusion injury (IRI) is a major source of injury during many surgical procedures on the liver, and severe IRI can lead to post-hepatectomy liver…
2019 American Transplant Congress
Evaluation of New Baskent University Preservation Solution for Liver, Kidney and Intestine Graft during Cold Ischemia: Preliminary Experimental Animal Study
M. Haberal¹, M. Kirnap¹, R. Erdem², H. Ozdemir³, M. Lux², D. Bacanli⁴
¹Transplantation, Baskent University, Ankara, Turkey, ²Pharmacology, Baskent University, Ankara, Turkey, ³Pathology, Baskent University, Ankara, Turkey, ⁴Experimental Laboratory, Baskent University, Ankara, Turkey
*Purpose: Despite significant advances in organ transplantation, damage caused to organs due to long cold ischemia time and perfusion solutions remains a serious hurdle. The…
2019 American Transplant Congress
Cryopreservation Allows for Extended Graft Survival in a Rat Orthotopic Hind Limb Model
S. A. Fidder¹, B. Oh¹, F. Messner¹, G. Furtmueller¹, K. Helke², E. Greene³, Z. Chen³, L. Campbell³, G. Brandacher¹, K. Brockbank³
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department Of Comparative Medicine, Medical University of South Carolina, Charleston, SC, ³Tissue Testing Technologies LLC, Charleston, SC
*Purpose: Vascularized composite allotransplantation (VCA) is a viable reconstructive option for devastating tissue defects. The growth of the field is restrained by the limited ischemia…
2018 American Transplant Congress
Long-Term HIF-1α Stabilization is Associated with Fibrosis in Rat Lung Allografts
K. Freischlag,¹ B. Ezekian,¹ P. Schroder,¹ J. Everitt,¹ J. Yoon,¹ M. Swiderska-Syn,³ W. Parker,¹ A. Diehl,¹ J. Kwun,¹ S. Knechtle.¹
¹Duke Transplant Center, Duke University, Durham, NC; ²Medical University of South Carolina, Charleston, SC.
Introduction: HIF-1α is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) and functions as a master transcriptional regulator of cellular and developmental…
2018 American Transplant Congress
Functional Reconstruction of Urogenital Tissue Defects Using VCA: A Novel Microsurgical Penis Transplant Model and Clinical & Histological Rejection Classification
S. Fidder,^1,4 G. Furtmüller,¹ B. Simons,² B. Kern,¹ D. Lough,¹ B. Oh,¹ M. Chicco,¹ C. Brayton,³ W. Lee,¹ D. Cooney,¹ R. Redett,¹ G. Brandacher.¹
¹Dept of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore; ²Dept of Urology, JHU SOM, Baltimore; ³Dept of Molecular & Comparative Pathobiology, JHU SOM, Baltimore; ⁴Plastic and Reconstructive Surgery, Erasmus University Medical Center, Rotterdam, Netherlands.
Background: Defects of male urogenital structures subsequent to major trauma are associated with severely reduced function and quality-of-life. As of recent, penis transplantation represents an…
2018 American Transplant Congress
Ex-Vivo Subnormothermic Oxygenated Machine Perfusion of Rodent Hindlimb: Feasibility Study to Elongate Preservation Time of Vascularized Composite Allograft
L. Burlage,^1,2 A. Lellouch,^3,4 S. Tessier,¹ C. Pendexter,¹ S. Cronin,¹ M. Schol,³ M. Randolph,³ R. Porte,² L. Lantieri,⁴ C. Cetrulo,³ K. Uygun.¹
¹Surgery, Massachusetts General Hospital/Harvard Medical School, Boston; ²Surgery, University Medical Center Groningen, Groningen, Netherlands; ³Plastic Surgery, Massachusetts General Hospital/Harvard Medical School, Boston; ⁴Plastic Surgery, European George Pompidou Hospital, Paris, France.
PURPOSE: A pressing challenge in the field of VCA is adequate tissue preservation. Static cold preservation, successfully used in field of solid organ transplantation, greatly…
2018 American Transplant Congress
BLyS^-/- Rats to Prevent Alloantibody Production
N. Bath,¹ B. Verhoven,¹ N. Wilson,¹ S. Reese,² L. Coons,¹ S. Panzer,² A. Djamali,² R. Redfield.¹
¹Surgery, University of Wisconsin, Madison, WI; ²Medicine, University of Wisconsin, Madison, WI.
Introduction: Antibody mediated rejection (AMR) is a major cause of kidney allograft failure. APRIL (A Proliferation Inducing Ligand) and BLyS (B Lymphocyte Stimulator) are two…
2018 American Transplant Congress
Noninvasive Quantization of Intra-Renal Allograft C4d Deposition with Targeted Ultrasound Imaging
T. Liao,¹ Y. Zhang,¹ J. Ren,² H. Zheng,¹ H. Zhang,² X. Liu,¹ T. Yin,² Q. Sun.¹
¹Organ Transplantation Research Institute, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; ²Department of Medical Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Antibody-mediated rejection (AMR) has emerged as the major cause of renal allograft dysfunction. C4d, a specific marker of AMR diagnosis, was strongly recommended for routine…
2018 American Transplant Congress
The Preclinical Application of the Tactile Discrimination Task in Rat Models
S-.H. Wu,^1,2 C-.J. Wen,^1,2 J-.J. Huang,^1,2,3 Y-.C. Pei,^1,2,3 C-.H. Lin,^1,2,4,5 H. Cheng,¹ Z-.L. Peng,^1,4,5 H-.I. Yang,⁶ F-.C. Wei.^1,2,5
¹Center for Vascularized Composite Allotransplantation, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²College of Medicine, Chang Gung University, Taoyuan, Taiwan; ³Department of Physical Medicine & Rehabilitation, Taoyuan Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁴Division of Trauma and Emergency Plastic Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁵Division of Plastic Reconstructive Microsurgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁶Department of Electronic Engineering, National Taipei University of Technology, Taipei, Taiwan.
Nerve reinnervation is an important issue in the field of vascularized composite allotransplantation (VCA). However, nowadays the effective treatment for enhancing the reinnervation after the…
2017 American Transplant Congress
Dual Treatment of Suboptimal Doses of CsA and MSC Infusion Fully Prevents Acute Rejection in an Allogenic Model of Renal Transplantation.
L. de Ramon,¹ A. Merino,¹ E. Ripoll,¹ N. Bolaños,¹ M. Gomà,³ J. Cruzado,^1,2 J. Grinyó,^1,2 J. Torras.^1,2
¹Experimental Nephrology, IDIBELL-UB, Hospitalet Llobregat, Barcelona, Spain; ²Nephrology, Hospital Universitari de Bellvitge, Hospitalet Llobregat, Barcelona, Spain; ³Pathology, Hospital Universitari de Bellvitge, Hopitalet Llobregat, Barcelona, Spain
The immunomodulatory characteristics of mesenchymal stem cells (MSCs) may lead to multifaceted strategies in rejection of organ transplantation. This study was designed to investigate the…