ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rat"

  • 2020 American Transplant Congress

    Metformin Improves Biomarkers of Calcineurin Inhibitor Related Nephrotoxicity

    M. R. Fernando, K. Taylor, S. Herath, A. Au, J. Erlich, Z. Endre

    Department of Nephrology, Prince of Wales Hospital, Randwick, Australia

    *Purpose: Calcineurin Inhibitors (CNIs) prevent transplant rejection but cause significant nephrotoxicity. Biomarkers of CNI nephrotoxicity could help drug dosing and improve long-term graft outcomes. As…
  • 2020 American Transplant Congress

    Two Novel Methods to Establish Rat Kidney Transplantation Model

    M. Zheng, Z. Gui, Z. Wang, J. Wei, X. Ju, R. Tan, M. Gu

    Jiangsu Province Hospital, Nanjing, China

    *Purpose: Rat kidney transplantation model is a standard animal model for the anti-rejection research of kidney transplantation. However, the current methods of the model require…
  • 2020 American Transplant Congress

    Oral Administration of Nano-Sized Silicon Particles Regulates Gene Expression Related to Oxidative Stress and Attenuates Rat Renal Ischemia Reperfusion Injury

    M. Kawamura1, R. Imamura1, Y. Kobayashi2, A. Taniguchi1, S. Nakazawa1, T. Kato1, T. Abe1, H. Kobayashi2, N. Nonomura1

    1Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, 2The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan

    *Purpose: Organ ischemia reperfusion injury (IRI) is unavoidable in kidney transplantation and induces reactive oxygen species and causes organ damage. Although the effectiveness of hydrogen…
  • 2020 American Transplant Congress

    Rat Hind Limb Transplant Model to Assess Vascularized Composite Allograft (VCA) Inflammation and Ischemia Reperfusion Injury

    Z. Wang1, A. B. Harrant1, Y. Wang1, K. Washington1, E. Farkash2, C. A. Huang1

    1Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, 2Pathology, University of Michigan, Ann Arbor, MI

    *Purpose: Vascularized composite allografts are potential surgical solutions for patients with traumatic or disfiguring injuries but are highly immunogenic and require elevated levels of immunosuppression.…
  • 2020 American Transplant Congress

    ANG-3777, A Hepatic Growth Factor Mimetic, Attenuates Post-Transplant Renal Dysfunction in Rats

    P. Narayan, I. D. Goldberg

    Angion Biomedica, Uniondale, NY

    *Purpose: ANG-3777, a small-molecule mimetic of hepatocyte growth factor (HGF), has the potential to exert antifibrotic and nephroprotective effects. A rat model of renal transplantation…
  • 2019 American Transplant Congress

    Immunosuppression Increases Regenerative Potential of Adult Rat Cardiac Progenitor Cells in Allogeneic Rat Myocardial Infarction Model

    M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, M. Y. Arfat, C. Ambastha, D. Morales, F. Xuebin, G. J. Bittle, D. Li, S. Kaushal

    Department of Surgery, University of Maryland, Baltimore 21201, MD

    *Purpose: Cardiac progenitor cells (CPCs, c-kit+) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, immune response to…
  • 2019 American Transplant Congress

    Stem Cell and Granulocyte- Colony Stimulating Factor Therapies to Improve Functional Outcomes in Limb Transplantation

    J. Weiss1, C. Phillips1, E. Malin1, V. Gorantla2, S. K. Salgar3

    1Surgery, Madigan Army Medical Center, Tacoma, WA, 2Surgery, Wake Forest University, Salem, NC, 3Clinical Investigation, Madigan Army Medical Center, Tacoma, WA

    *Purpose: Although, over 200 clinical Vascularized Composite Allotransplantation (VCA) such as hands, legs, and face have been performed worldwide, still there are many challenges such…
  • 2019 American Transplant Congress

    CD38 Inhibition: A Novel Target for Hepatic Ischemia Reperfusion Injury

    C. Akateh1, B. F. Reader1, Y. Lee1, J. Kim1, K. Maynard1, K. W. Washburn1, J. L. Zweier2, B. A. Whitson1, S. M. Black1

    1Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, 2The Ohio State University Wexner Medical Center, Columbus, OH

    *Purpose: Ischemia/reperfusion injury (IRI) is a major source of injury during many surgical procedures on the liver, and severe IRI can lead to post-hepatectomy liver…
  • 2019 American Transplant Congress

    Evaluation of New Baskent University Preservation Solution for Liver, Kidney and Intestine Graft during Cold Ischemia: Preliminary Experimental Animal Study

    M. Haberal1, M. Kirnap1, R. Erdem2, H. Ozdemir3, M. Lux2, D. Bacanli4

    1Transplantation, Baskent University, Ankara, Turkey, 2Pharmacology, Baskent University, Ankara, Turkey, 3Pathology, Baskent University, Ankara, Turkey, 4Experimental Laboratory, Baskent University, Ankara, Turkey

    *Purpose: Despite significant advances in organ transplantation, damage caused to organs due to long cold ischemia time and perfusion solutions remains a serious hurdle. The…
  • 2019 American Transplant Congress

    Cryopreservation Allows for Extended Graft Survival in a Rat Orthotopic Hind Limb Model

    S. A. Fidder1, B. Oh1, F. Messner1, G. Furtmueller1, K. Helke2, E. Greene3, Z. Chen3, L. Campbell3, G. Brandacher1, K. Brockbank3

    1Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 2Department Of Comparative Medicine, Medical University of South Carolina, Charleston, SC, 3Tissue Testing Technologies LLC, Charleston, SC

    *Purpose: Vascularized composite allotransplantation (VCA) is a viable reconstructive option for devastating tissue defects. The growth of the field is restrained by the limited ischemia…
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