ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rat"

  • 2022 American Transplant Congress

    Performance of Aged Liver Grafts in a Rat Model of Normothermic Ex Vivo Liver Machine Perfusion

    S. Moosburner1, M. Zimmer1, J. M. Gassner1, N. Roschke1, N. Berndt2, J. Michelotto1, K. H. Hillebrandt1, J. Pratschke1, I. M. Sauer1, N. Raschzok1

    1Department of Surgery, Experimental Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 2Institute of Biochemistry, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

    *Purpose: We aimed to characterize the performance of old vs. young liver grafts in a standardized rat model of normothermic ex vivo liver machine perfusion…
  • 2022 American Transplant Congress

    Delivery of Plasmin During Machine Perfusion or Cold Storage Flush Improves Early Transplant Outcomes in aRat Dcd Liver Transplant Model

    N. Abraham1, M. Zhang1, P. Cray2, R. Neill1, G. Cywinska1, J. Migaly1, R. Kahan1, A. Pontula1, J. Penaflor1, Q. Gao1, K. P. Samy1, J. J. Pollara2, V. Novokhatny3, M. G. Hartwig1, A. S. Barbas1

    1Duke Division of Abdominal Transplant Surgery, Duke Ex-Vivo Organ Lab (DEVOL), Durham, NC, 2Duke Division of Surgical Sciences, Pollara lab, Durham, NC, 3Bioscience Industrial Group, Grifols R&D, Durham, NC

    *Purpose: Ischemic injury of the peribiliary glands and vascular plexus has been described in DCD livers and correlates with the development of cholangiopathy. Investigators have…
  • 2022 American Transplant Congress

    Allogenic Cardiac Progenitor Cells Transplantation with Immune Suppressant Cyclosporine a Recovers Myocardial Infarction in Rodent Model

    M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Chen, S. Guru, A. Stefanowicz, A. Bilewska, S. Zarinebaf, G. Zhi-Dong, S. Kaushal

    Pediatrics, Lurie Childrens Hospital, Chicago, IL

    *Purpose: Cardiac progenitor cells (CPCs) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, auto and allo immune…
  • 2022 American Transplant Congress

    Circulating Galectin-3 Levels Increase in Syngeneic Rat Recipients of Vascularized Composite Allografts Subjected to Prolonged Ischemia

    Z. Wang1, B. Li1, Y. Wang1, D. Yoeli1, N. Nakra1, N. Limon De La Rosa1, A. A. Su1, A. Jani1, D. W. Mathes1, K. M. Washington1, E. Farkash2, C. A. Huang1

    1University of Colorado, Denver | Anschutz Medical Campus, Aurora, CO, 2University of Michigan, Ann Arbor, Ann Arbor, MI

    *Purpose: During the process of transplantation, organs and tissue are necessarily subjected to some degree of hypoxic and ischemic injury during procurement, preservation and following…
  • 2022 American Transplant Congress

    Evaluation of UW-Based Solutions Formulated to Be Anti-Apoptotic and Neuroprotective of Retinal Ganglion Cells (RGCs) Following Whole Eye Transplantation (WET) in a Rat Model

    N. J. Khatter1, Y. Wang1, B. Li1, C. R. Owens1, A. H. Jani2, C. A. Huang1, R. W. Nickells3, A. A. Su1, K. M. Washington1

    1Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Colorado, Anschutz Medical Campus, Aurora, CO, 2Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, 3Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI

    *Purpose: As vascularized composite allotransplantation (VCA) of an intact optical system to restore vision requires overcoming RGC apoptosis caused by ischemia reperfusion injury, UW and…
  • 2022 American Transplant Congress

    Exploration of the Optimal pH in Hypothermic Machine Perfusion for Rat Liver Grafts Retrieved from Circulatory Death

    S. Sakamoto1, M. Fukai1, K. Shibata1, H. Bochimoto2, N. Mohd Zin2, N. Kawamura1, T. Ishikawa1, M. Fujiyoshi1, T. Shimamura3, A. Taketomi1

    1Department of Gastroenterological Surgery 1, Hokkaido University Graduate School, Sapporo, Japan, 2Department of Cell Physiology, The Jikei University School of Medicine, Tokyo, Japan, 3Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan

    *Purpose: Although some investigators have reported favorable results of hypothermic machine perfusion (HMP) in liver transplantation, the efficacy to the hepatic graft retrieved from circulatory…
  • 2022 American Transplant Congress

    Comparison of Vasodilators in Dual Vessel Normothermic Ex Vivo Liver Machine Perfusion of Rat Liver Grafts

    J. M. Gassner, F. Strobl, J. Michelotto, K. Kristina, V. Muth, M. Zimmer, L. Gilles, S. Moosburner, J. Pratschke, I. Sauer, N. Raschzok

    Department of Surgery, Experimental Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

    *Purpose: Small animal models of normothermic ex vivo liver machine perfusion (NEVLP) comparable to clinically used protocols are vital to perform translational studies on organ…
  • 2021 American Transplant Congress

    Galectin-3 Blockade Can Decrease Reperfusion Injury in Response to Ischemia in a Rat Hind Limb Transplant Model

    Z. Wang1, Y. Wang1, D. Yoeli1, B. Li1, A. Su1, D. Mathes1, K. Washington1, E. Farkash2, C. A. Huang1

    1University of Colorado, Aurora, CO, 2University of Michigan, Ann Arbor, Ann Arbor, MI

    *Purpose: Vascularized composite allograft (VCA) transplant is technically feasible and results in successful clinical outcomes. However, skin and muscle containing VCA is highly susceptible to…
  • 2021 American Transplant Congress

    Platelets Stimulate Liver Regeneration After Partial Liver Transplantation

    K. Takahashi, C. Liang, K. Furuya, T. Oda

    GI and HBP Surgery, University of Tsukuba, Tsukuba, Japan

    *Purpose: Living donor liver transplant (LDLT) can sometimes be associated with impaired regeneration and severe ischemia/reperfusion (I/R) injury in the liver graft, resulting in small-for-size…
  • 2021 American Transplant Congress

    Single Cell RNA Sequencing Reveals a Global Increase in Inflammatory Gene Signature Following Normothermic Ex Vivo Liver Perfusion

    K. Carlson, J. Pavan-Guimaraes, B. Verhoven, J. Verhagen, F. Najmabadi, D. P. Al-Adra

    Surgery, University of Wisconsin, Madison, WI

    *Purpose: Normothermic ex vivo liver perfusion (NEVLP) provides an exciting system for improved organ preservation and optimized therapeutic agent delivery to a donor liver prior…
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