Articles tagged "Lung transplantation"

2020 American Transplant Congress
Effects of Alpha-1 Proteinase Replacement Continuation Post-Lung Transplantation in Alpha-1 Antitrypsin Deficiency: A Single Center Case Series
M. Bremer, A. Feist, M. Mariski, G. Yung, T. Floreth, E. Schonhoft, G. Schooler, E. Golts, K. Afshar
Lung Transplant, University of California San Diego, La Jolla, CA
*Purpose: Alpha-1 antitrypsin deficiency (AATD) accounts for approximately 6% of all lung transplants (LTx) performed annually. The benefit of replacement with alpha-1 proteinase inhibitor (A1-PI)…
2020 American Transplant Congress
Impact of Donor Lung Pathogenic Bacteria Detected by Next-Generation Sequencing on Early Post-Transplant Outcomes in Lung Transplant Recipients
D. Liu, J. Zhang, J. Chen
Lung Transplant Center, Wuxi People's Hospital, Wuxi, China
*Purpose: The effect of donor lung pathogenic bacteria on the prognosis of lung transplantation is not clear. We used the technique of next-generation sequencing (NGS)…
2020 American Transplant Congress
Is Azathioprine the Right Choice in De Novo Lung Transplantation?
A. Chan¹, B. Sirandas¹, A. Carlson¹, C. Truax¹, B. Clark¹, I. Hall², B. Cahill³, L. Smith¹
¹Pharmacy, University of Utah Health, Salt Lake City, UT, ²Nephrology, University of Utah Health, Salt Lake City, UT, ³Pulmonary, University of Utah Health, Salt Lake City, UT
*Purpose: The antiproliferative of choice in lung transplantation (LT) remains controversial. Limited data exists on azathioprine (AZA) dose reductions or the conversion of AZA to…
2020 American Transplant Congress
Perioperative Results of Lung Transplantation in a Newly Established, High-Volume Lung Transplantation Center in China
F. Xiao¹, Z. Zhang¹, H. Feng¹, M. Li², W. Chen³, C. Liang¹, J. Chen³
¹Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing, China, ²Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China, ³Department of Lung Transplantation, China-Japan Friendship Hospital, Beijing, China
*Purpose: The number of patients with end-stage lung disease is huge in China, lung transplantation is the only effective method. By presenting the perioperative results…
2020 American Transplant Congress
Evolution of Molecular Lung Transplant Biopsy Assessment: Rejection Can be Detected in Mucosal as Well as Transbronchial Biopsies
M. D. Parkes¹, K. Halloran², P. Halloran², &. the INTERLUNG Study Group³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: We recently developed a Molecular Microscope® (MMDx) rejection assessment platform for mucosal biopsies from the third airway bifurcation (3BMB) and transbronchial biopsies (TBB) from…
2020 American Transplant Congress
Risk Aversion in Lung Transplantation: Organ Procurement Organizations Differ in Willingness to Pursue Non-Ideal Donor Organs
S. E. Halpern¹, A. McConnell², S. Peskoe², V. Raman³, O. K. Jawitz³, A. Y. Choi¹, J. C. Haney³, J. A. Klapper³, M. G. Hartwig³
¹Duke University School of Medicine, Durham, NC, ²Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, ³Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Lungs from non-ideal deceased donors are disproportionally discarded despite evidence that waitlisted candidates benefit from use of these organs. Organ procurement organizations (OPOs) individually…
2020 American Transplant Congress
Amiodarone Use in Lung Transplant Recipients with New Onset Atrial Arrhythmias
E. Klipsch¹, R. Rachwan², I. KutKut³, D. Roe², C. Hage², T. Hathaway¹, R. S. Mangus²
¹Indiana University School of Medicine, Indianapolis, IN, ²IU Health, Indianapolis, IN, ³New York Presbyterian Hospital, New York, NY
*Purpose: Atrial arrhythmias occur in 16-46% of patients after lung transplant, and most of these are atrial fibrillation or flutter. Standard therapy is described as…
2020 American Transplant Congress
Association between Pre-Transplant Frailty and Increased Length of Stay after Lung Transplantation
J. Schaenman, N. Ventigan, J. Huang, S. Jaladanki, L. Shih, S. Gee, D. Sayah, S. S. Weigt, A. Ardehali, R. Biniwale, D. Goldwater
David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Given the growing numbers of older lung transplant candidates, there has been increasing interest in using frailty assessment for risk stratification of transplant candidates.…
2020 American Transplant Congress
Association of Discharge Immunosuppressive Regimen with Treated Acute Rejection and Bronchiolitis Obliterans Syndrome in Adult Lung Transplantation: An Analysis of Organ Procurement and Transplantation Network Data
W. S. Cherikh¹, B. J. Plucinski¹, S. Palmer², W. E. Fitzsimmons³
¹United Network for Organ Sharing, Richmond, VA, ²Duke University Hospital, Durham, NC, ³Fitzsimmons LLC, Vernon Hills, IL
*Purpose: The optimal immunosuppressive (IS) regimen after lung (LU) transplant is unknown. We conducted the current analysis to compare the effect of four different discharge…
2020 American Transplant Congress
Prolonged Cold Ischemia Increases Reactive Oxygen Species Activates Autophagy by Enhancing Glycolysis in the Graft Through the mTOR Signaling Pathway in Orthotopic Lung Transplantation of Rats
H. Lin¹, S. Dai², W. Liu³, X. Lin², B. Yu², S. Chen³, S. Liu², J. Tang²
¹Thoracic Surgery, Wuhan University, Renmin Hospital, Wuhan, China, ²Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China, ³Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China
*Purpose: The aim of the present study is to investigate the mechanisms by which prolonged CI influences the autophagy in the graft lung, in which…