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Articles tagged "Islets"

  • 2021 American Transplant Congress

    A Small Molecule Inhibitor of Toll-like Receptor-4 TAK-242 Attenuates IBMIR Against Human Islets

    J. Mattke1, S. Vasu1, K. Kumano1, Y. Liu1, C. M. Darden1, M. C. Lawrence1, R. R. Kane2, B. Naziruddin1

    1Baylor University Medical Ctr, Dallas, TX, 2Baylor University, Waco, TX

    *Purpose: A large portion of grafted islets are lost shortly after infusion due to the instant blood mediated inflammatory reaction (IBMIR). In our previous studies,…
  • 2021 American Transplant Congress

    Bone Marrow-Derived Mesenchymal Stem Cells Improve Rat Islet Graft Revascularization by Upregulating Isl1

    W. Ying, J. Wang, X. Ding

    Kidney Transplantation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi An, China

    *Purpose: Revascularization of the transplant islet is a crucial step that defines the success rate of patient recovery. Though bone marrow-derived mesenchymal stem cells (BMSCs)…
  • 2021 American Transplant Congress

    Endocrine Cell Identity and HOMA-B In Patients with Chronic Pancreatitis Undergoing Islet Auto-transplantation

    C. A. Beamish1, O. Gaber2, O. M. Sabek2

    1Surgery, Houston Mehodist Hospital, Houston, TX, 2Surgery, Houston Mehodist, Houston, TX

    *Purpose: Islet identity loss is an emergent factor in dysglycemia in diabetes, islet transplantation, and chronic pancreatitis (CP). Pancreatectomy and islet auto-transplantation (PIAT) for CP…
  • 2021 American Transplant Congress

    TPIAT Outcomes in Diabetic and Non-diabetic Patients

    M. A. Kanak, J. B. Spriggs, P. Coughenour, J. Kalivarathan, P. Saravanan, M. Levy

    Virginia Commonwealth University, Richmond, VA

    *Purpose: Total pancreatectomy with islet auto-transplant (TPIAT) has become a mainstay treatment for patients who suffer from refractory chronic pancreatitis. It has consistently been shown…
  • 2021 American Transplant Congress

    Comparative Outcomes of TPIAT in African American and Caucasian Patients with Chronic Pancreatitis

    M. A. Kanak, J. B. Spriggs, P. Coughenour, J. Kalivarathan, P. Saravanan, M. F. Levy

    Virginia Commonwealth University, Richmond, VA

    *Purpose: Total pancreatectomy with islet auto-transplantation (TPIAT) is becoming the standard of care for patients with chronic pancreatitis, as it provides pain relief and improved…
  • 2021 American Transplant Congress

    Diffuse Calcification Pattern in Chronic Pancreatitis Has Two Aspects in Total Pancreatectomy with Islet Autotransplantation: Bad Sign for Islet Graft Function and Good Sign for Pain Relief

    Y. Liu, K. Kumano, J. Mattke, C. Darden, S. Vasu, M. Lawrence, G. Testa, A. Gupta, E. Beecherl, N. Onaca, B. Naziruddin

    Baylor University Medical Ctr, Dallas, TX

    *Purpose: Chronic pancreatitis (CP) is characterized by progressive inflammation and fibrosis of the pancreas. The diagnosis of CP is based on pancreatic calcifications, ductal dilatation,…
  • 2021 American Transplant Congress

    Psychosocial Outcomes 1-year Post Total Pancreatectomy and Autologous Islet Cell Transplant

    J. Steel1, A. Amin1, M. Wijkstrom1, A. Zureikat1, E. Tillman1, R. Jones1, D. Yadav1, A. Slivka1, A. Phillips1, M. Bellin2, A. Carroll3, A. Humar1

    1University of Pittsburgh, Pittsburgh, PA, 2University of Minnesota, Minneapolis, MN, 3University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: A paucity of research regarding the psychosocial outcomes after-total pancreatectomy and autologous islet cell transplantation exists. The aim of the study was to examine…
  • 2021 American Transplant Congress

    Two Hundred Total Pancreatectomy with Islet Autotransplantation Cases: A Single Center Experience

    K. Kumano1, S. Bruer1, G. Saracino1, M. Lawrence1, G. Testa1, A. Gupta1, N. Onaca1, E. Beecherl1, M. F. Levy2, B. Naziruddin1

    1Baylor University Medical Ctr, Dallas, TX, 2Virginia Commonwealth University, Richmond, VA

    *Purpose: Total pancreatectomy and islet autotransplantation (TPIAT) for patients with uncontrolled chronic pancreatitis has been performed at our center from 2006 and the number of…
  • 2021 American Transplant Congress

    Islet Allotransplantation Into Pre-vascularized Sernova Cell PouchTM – Preliminary Results from the University of Chicago

    P. J. Bachul1, P. E. Borek1, G. S. Generette1, A. Perez-Gutierrez1, K. Jayant1, K. Golab1, L. Basto1, L. Perea1, M. Tibudan1, C. Thomas2, L. Philipson2, J. Fung1, P. Witkowski1

    1Surgery, University of Chicago, Chicago, IL, 2Medicine, University of Chicago, Chicago, IL

    *Purpose: Previous first-in-human pilot study showed safety but the conditions did not allow for detectable islet function post-transplantation into the pre-vascularized Sernova Cell Pouches (SCPs)…
  • 2021 American Transplant Congress

    Evaluation of Preperitoneal Space as an Extrahepatic Transplant Site in Clinical Total Pancreatectomy with Islet Autotransplantation

    K. Kumano, B. Naziruddin, S. Bruer, G. Saracino, M. Lawrence, G. Testa, A. Gupta, E. Beecherl, N. Onaca

    Baylor University Medical Ctr, Dallas, TX

    *Purpose: Total pancreatectomy and intraportal islet autotransplantation (TPIAT) is an effective treatment for patients with refractory chronic pancreatitis. Large volume islet preparations cannot always be…
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