Articles tagged "Islets"

2020 American Transplant Congress
Pancreatic Mesenchymal Stromal Cells (MSC) Contain a Subset of Islet Progenitor Cells Capable of Regenerating Islets and Reversing Diabetes
C. M. Darden¹, S. Vasu², K. Kumano¹, Y. Liu², P. Saravanan³, B. Naziruddin², M. Lawrence²
¹Institute of Biomedical Studies, Waco, TX, ²Baylor University Medical Ctr, Dallas, TX, ³Transplant Surgery Department, VCU, Richmond, VA
*Purpose: To identity islet precursor cells residing in pancreatic MSC culture preparations that contribute to islet regeneration and restoration of islet cell function in both…
2020 American Transplant Congress
Contamination of Acinar Cells Impairs Therapeutic Effect of Islet Transplantation Due to Induction of Inflammatory Reaction in Not Only Graft Islets but Also Hepatic Parenchyma
K. Chinen, G. Yoshimatsu, N. Sakata, S. Kodama
Regenerative Medicine and Transplantation, Fukuoka University, Fukuoka City, Japan
*Purpose: Islet transplantation is a promising treatment option for type 1 diabetes. Edmonton protocol recommended that over 30 % purity of islets is essential for…
2020 American Transplant Congress
The Mechanism How the Transplanted Islets Engraft Into White Adipose Tissue
N. Sakata, G. Yoshimatsu, T. Tanaka, R. Kawakami, S. Kodama
Department of Regenerative Medicine and Transplantation, Fukuoka University, Fukuoka, Japan
*Purpose: While islet transplantation is recognized as a promising therapeutic option for severe diabetes mellitus (DM), especially type 1 DM, it still faces to various…
2020 American Transplant Congress
Beta Cell Replacement Therapy in Nonuremic Patients with Brittle T1DM Allows for Durable Long Term Insulin Independence Halting Progression of Secondary Diabetic Complications
P. J. Bachul¹, D. J. Grybowski¹, R. Anteby², L. Basto¹, L. Perea¹, K. Golab¹, L. Wang¹, M. Tibudan¹, A. Perez-Gutierrez¹, M. Komorniczak³, A. Lucander¹, P. Borek¹, M. Dimitrov¹, J. Fung¹, P. Witkowski¹
¹Surgery, University of Chicago, Chicago, IL, ²Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ³Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
*Purpose: Beta cell replacement therapy in form of pancreas or islet transplantation is the only effective treatment for patients suffering from hypoglycemic unawareness despite intensive…
2020 American Transplant Congress
High Laminin Alpha 5 Expression is Observed in the Pancreas of Chronic Pancreatitis Patients and Correlates with Poor Autologous Islet Transplant Outcome
Y. Liu, K. Kumano, S. Vasu, C. M. Darden, M. Lawrence, B. Naziruddin
Baylor University Medical Ctr, Dallas, TX
*Purpose: During chronic pancreatitis (CP), the extracellular matrix (ECM) of the pancreas is destroyed by a vicious cycle of parenchymal autodigestion by digestive exocrine enzymes…
2020 American Transplant Congress
Total Pancreatectomy with Islet Autotransplantation in Diabetic and Prediabetic Patients with Intractable Chronic Pancreatitis
P. J. Bachul¹, D. J. Grybowski¹, R. Anteby², L. Basto¹, L. Perea¹, K. Golab¹, L. Wang¹, M. Tibudan¹, A. Perez-Gutierrez¹, M. Komorniczak³, S. Nagpal⁴, A. Lucander¹, P. Borek¹, M. Dimitrov¹, J. Fung¹, J. B. Matthews¹, P. Witkowski¹
¹Surgery, University of Chicago, Chicago, IL, ²Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ³Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland, ⁴Medicine, University of Chicago, Chicago, IL
*Purpose: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment option for non-diabetic patients with intractable chronic pancreatitis. The outcome and potential benefits for…
2020 American Transplant Congress
Long-Term Outcomes with Islet Alone and Islet-after-Kidney Transplantation for Type 1 Diabetes in the Clinical Islet Transplantation Consortium
M. R. Rickels¹, T. L. Eggerman², L. Bayman³, J. C. Qidwai³, R. Alejandro⁴, N. D. Bridges⁵, B. J. Hering⁶, J. F. Markmann⁷, P. A. Senior⁸, L. G. Hunsicker³
¹Institute for Diabetes, Obesity & Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, MD, ³University of Iowa, Iowa City, IA, ⁴University of Miami, Miami, FL, ⁵National Institute of Allergy and Infectious Disease, Bethesda, MD, ⁶University of Minnesota, Minneapolis, MN, ⁷Massachusetts General Hospital, Boston, MA, ⁸University of Alberta, Edmonton, AB, Canada
*Purpose: Phase 3 studies of islet transplant alone (ITA; n=48) and islet-after-kidney (IAK; n=24) transplantation in type 1 diabetes complicated by severe hypoglycemic events (SHE)…
2020 American Transplant Congress
Long-Term Islet Allo- and Xenograft Survival is Promoted by Immunoglobulin M Immunotherapy
M. Ma, K. Brayman, P. Chhabra
Department of Surgery, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if islet allo- and xenotransplant rejection is mitigated by IgM immunotherapy.*Methods: a) New onset diabetic NOD mice (n=14) were treated with IgM…
2020 American Transplant Congress
Evaluation of US Doppler Examination of Portal Flow Dynamics in Patients with Total Pancreatectomy and Autologous Islet Cell Transplant
B. M. Williams, X. Baldwin, J. S. Vonderau, C. S. Desai
University of North Carolina, Chapel Hill, NC
*Purpose: The aim of this study is to evaluate US doppler flow dynamics following total pancreatectomy and autologous islet cell transplant (TPAIT) and establish any…
2020 American Transplant Congress
Pancreas Transplant in Chronic Kidney Disease for Type 1 Diabetic Patients
R. A. Choudhury, D. Yoeli, H. B. Moore, H. Yaffe, K. D. Conzen, T. L. Nydam, P. T. Kennealey
Department of Surgery- Division of Transplantation Surgery, University of Colorado Hospital, Aurora, CO
*Purpose: Although both pancreas transplantation alone (PTA) and islet cell transplantation (ICT) have been associated with peri-operative declines in eGFR, the magnitude of decline is…