2021 American Transplant Congress
Comparative Outcomes of TPIAT in African American and Caucasian Patients with Chronic Pancreatitis
Virginia Commonwealth University, Richmond, VA
*Purpose: Total pancreatectomy with islet auto-transplantation (TPIAT) is becoming the standard of care for patients with chronic pancreatitis, as it provides pain relief and improved…2021 American Transplant Congress
Diffuse Calcification Pattern in Chronic Pancreatitis Has Two Aspects in Total Pancreatectomy with Islet Autotransplantation: Bad Sign for Islet Graft Function and Good Sign for Pain Relief
Baylor University Medical Ctr, Dallas, TX
*Purpose: Chronic pancreatitis (CP) is characterized by progressive inflammation and fibrosis of the pancreas. The diagnosis of CP is based on pancreatic calcifications, ductal dilatation,…2021 American Transplant Congress
Psychosocial Outcomes 1-year Post Total Pancreatectomy and Autologous Islet Cell Transplant
*Purpose: A paucity of research regarding the psychosocial outcomes after-total pancreatectomy and autologous islet cell transplantation exists. The aim of the study was to examine…2021 American Transplant Congress
Two Hundred Total Pancreatectomy with Islet Autotransplantation Cases: A Single Center Experience
1Baylor University Medical Ctr, Dallas, TX, 2Virginia Commonwealth University, Richmond, VA
*Purpose: Total pancreatectomy and islet autotransplantation (TPIAT) for patients with uncontrolled chronic pancreatitis has been performed at our center from 2006 and the number of…2021 American Transplant Congress
Islet Allotransplantation Into Pre-vascularized Sernova Cell PouchTM – Preliminary Results from the University of Chicago
1Surgery, University of Chicago, Chicago, IL, 2Medicine, University of Chicago, Chicago, IL
*Purpose: Previous first-in-human pilot study showed safety but the conditions did not allow for detectable islet function post-transplantation into the pre-vascularized Sernova Cell Pouches (SCPs)…2021 American Transplant Congress
Evaluation of Preperitoneal Space as an Extrahepatic Transplant Site in Clinical Total Pancreatectomy with Islet Autotransplantation
Baylor University Medical Ctr, Dallas, TX
*Purpose: Total pancreatectomy and intraportal islet autotransplantation (TPIAT) is an effective treatment for patients with refractory chronic pancreatitis. Large volume islet preparations cannot always be…2021 American Transplant Congress
Donor Mhc-independent Islet Rejection in Autoimmune Diabetes: Implications for Stem Cell Therapy
*Purpose: Stem cell technology is an attractive approach for generating insulin-producing cells for transplantation in insulin-dependent diabetes and potentially can be genetically modified. One recent…2021 American Transplant Congress
Targeting Calcineurin/nfatc2 Signaling to Restore Pancreatic Beta-cell Function in Islet Transplantation
1Baylor University Medical Ctr, Dallas, TX, 2Baylor University Medical Ctr, Allen, TX
*Purpose: Pancreatic beta cells dedifferentiate upon exposure to metabolic and inflammatory stress characterized by loss of beta-cell identity genes, expression of beta-cell disallowed genes, and…2021 American Transplant Congress
Exosomal DAMP Proteins Released During Islet Isolation Affects TPIAT Outcomes
Hume Lee Islet Cell Transplantation Lab, Department of Surgery, VCU Health, Richmond, VA
*Purpose: Isolation of islets cause significant stress that results in the release of immunogenic factors called damage-associated molecular patterns (DAMPs) which can induce inflammatory signaling…2021 American Transplant Congress
LacripepTM-like Peptide N-104 Promotes Beta Cell Proliferation in Murine Pancreatic Islets
University of Virginia Health System, Charlottesville, VA
*Purpose: To monitor time-dependent cellular changes, with emphasis on beta cell regeneration, in pancreatic islets following treatment with LacripepTM-like peptide N-104 by mass cytometry. Background:…
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