2022 American Transplant Congress
Utilizing Microporous Annealed Particle (MAP) Gel as an Immunomodulatory Carrier for Islet Delivery
*Purpose: To investigate if coating with MAP gel improves dissociated or whole islet transplantation outcome.*Background: MAP gel platform technology is composed of hydrogel microspheres that…2022 American Transplant Congress
Bioink Based on the DECM for 3D-Bioprinting of Bionic Pancreas – First Results of Animal
*Purpose: Tissue engineering is an interdisciplinary field involving activities based on two interrelated areas: developing new methods to repair, regenerate and replace damaged tissues and…2022 American Transplant Congress
Vitrification of Pancreatic Islets and Transplantation
1University of Minnesota, Minneapolis, MN, 2Mayo Clinic, Rochester, MN
*Purpose: A limitation to potential cure for diabetes through islet transplantation is insufficient islet equivalence (IEQ) from a single donor to achieve insulin independence in…2022 American Transplant Congress
FasL-Presenting PEG Microgels Supports Sustained Graft Survival in Nonhuman Primates in the Absence of Continuous Immunosuppression
*Purpose: Broad application of allogeneic islets for T1D treatment is curtailed by the use of chronic immunosuppression to control rejection. Teff cells are the major…2022 American Transplant Congress
Engineered Adaptable Human Endothelial Cells Enable Durable Engraftment of Subcutaneously Transplanted Islets
Weill Cornell Medical College, New York, NY
*Purpose: The current clinical practice of islet transplantation into the portal vein is suboptimal, with reduced vascularization limiting successful engraftment and the inability for monitoring…2021 American Transplant Congress
Bone Marrow-Derived Mesenchymal Stem Cells Improve Rat Islet Graft Revascularization by Upregulating Isl1
Kidney Transplantation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi An, China
*Purpose: Revascularization of the transplant islet is a crucial step that defines the success rate of patient recovery. Though bone marrow-derived mesenchymal stem cells (BMSCs)…2021 American Transplant Congress
A Small Molecule Inhibitor of Toll-like Receptor-4 TAK-242 Attenuates IBMIR Against Human Islets
1Baylor University Medical Ctr, Dallas, TX, 2Baylor University, Waco, TX
*Purpose: A large portion of grafted islets are lost shortly after infusion due to the instant blood mediated inflammatory reaction (IBMIR). In our previous studies,…2021 American Transplant Congress
LacripepTM-like Peptide N-104 Increases Insulin Secretion and Promotes Islet Transplantation Outcomes
University of Virginia Health System, Charlottesville, VA
*Purpose: To study if LacripepTM-like peptide N-104 promotes beta-cell stabilization and islet transplantation outcomes. Background: Lacritin is a multifunctional tear protein with prosecretory, prosurvival and…2021 American Transplant Congress
Islet Isograft Transplantation Improves Insulin Sensitivity in a Murine Model of Type 2 Diabetes
Asan Medical Center, Seoul, Songpa, Korea, Republic of
*Purpose: Type 2 diabetes develops in the presence of chronic overnutrition and genetic susceptibility, and causes insulin resistance and relative insulin deficiency. We hypothesized that…2021 American Transplant Congress
LacripepTM-like Peptide N-104 Promotes Beta Cell Proliferation in Murine Pancreatic Islets
University of Virginia Health System, Charlottesville, VA
*Purpose: To monitor time-dependent cellular changes, with emphasis on beta cell regeneration, in pancreatic islets following treatment with LacripepTM-like peptide N-104 by mass cytometry. Background:…
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