ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Islets"

  • 2020 American Transplant Congress

    Inhibiting NLRP3 Inflammasome Ameliorates Glucose Fluctuation Through Reducing Apoptosis and Infiltration of Inflammatory Cells after Intraportal Islet Transplantation in Rodent Model

    G. Yoshimatsu, T. Matsuoka, K. Chinen, N. Sakata, S. Kodama

    Department of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    *Purpose: Islet transplantation is a useful treatment option for insulin dependent diabetes mellitus with severe hypoglycemic event. However, intraportal islet transplantation is known to induce…
  • 2020 American Transplant Congress

    Generation and Long-Term Culturing of AIPCs for Islet Replacement

    J. B. Pollett1, R. Bottino2, S. Bertera2, M. Trucco2, N. Thai2

    1Imagine Pharma, Pittsburgh, PA, 2Allegheny Health Network, Pittsburgh, PA

    *Purpose: Islet transplantation is one of the most promising hopes for a cure for type 1 diabetes, although islet shortage remains a serious concern. A…
  • 2020 American Transplant Congress

    AIPCs Home to and Engraft in the Pancreas When Injected Intravenously

    J. B. Pollett1, N. Thai2

    1Imagine Pharma, Pittsburgh, PA, 2Allegheny Health Network, Pittsburgh, PA

    *Purpose: AIPCs (Activated Islet Proliferating Cells) are a recently developed cell population generated from isolated islets of mice and humans. AIPCs are over 65% CD133-,…
  • 2020 American Transplant Congress

    Generation of Insulin-Producing Cells via Multiplex Epigenetic Engineering of Human Somatic Cells in 2 Weeks

    R. A. Naqvi1, W. Zhang1, A. Isidan1, C. Evans-Molina2, J. A. Fridell1, P. Li1, B. Ekser1

    1Division of Transplant Surgery, Indiana University, Indianapolis, IN, 2Diabetes Research Center, Indiana University, Indianapolis, IN

    *Purpose: Stem cell-derived β-cells not only promise a renewable supply of insulin-producing cells with negligible immunosuppression but may also provide a substrate for the identification…
  • 2020 American Transplant Congress

    Contamination of Acinar Cells Impairs Therapeutic Effect of Islet Transplantation Due to Induction of Inflammatory Reaction in Not Only Graft Islets but Also Hepatic Parenchyma

    K. Chinen, G. Yoshimatsu, N. Sakata, S. Kodama

    Regenerative Medicine and Transplantation, Fukuoka University, Fukuoka City, Japan

    *Purpose: Islet transplantation is a promising treatment option for type 1 diabetes. Edmonton protocol recommended that over 30 % purity of islets is essential for…
  • 2020 American Transplant Congress

    Pancreatic Mesenchymal Stromal Cells (MSC) Contain a Subset of Islet Progenitor Cells Capable of Regenerating Islets and Reversing Diabetes

    C. M. Darden1, S. Vasu2, K. Kumano1, Y. Liu2, P. Saravanan3, B. Naziruddin2, M. Lawrence2

    1Institute of Biomedical Studies, Waco, TX, 2Baylor University Medical Ctr, Dallas, TX, 3Transplant Surgery Department, VCU, Richmond, VA

    *Purpose: To identity islet precursor cells residing in pancreatic MSC culture preparations that contribute to islet regeneration and restoration of islet cell function in both…
  • 2020 American Transplant Congress

    Beta Cell Replacement Therapy in Nonuremic Patients with Brittle T1DM Allows for Durable Long Term Insulin Independence Halting Progression of Secondary Diabetic Complications

    P. J. Bachul1, D. J. Grybowski1, R. Anteby2, L. Basto1, L. Perea1, K. Golab1, L. Wang1, M. Tibudan1, A. Perez-Gutierrez1, M. Komorniczak3, A. Lucander1, P. Borek1, M. Dimitrov1, J. Fung1, P. Witkowski1

    1Surgery, University of Chicago, Chicago, IL, 2Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 3Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland

    *Purpose: Beta cell replacement therapy in form of pancreas or islet transplantation is the only effective treatment for patients suffering from hypoglycemic unawareness despite intensive…
  • 2020 American Transplant Congress

    The Mechanism How the Transplanted Islets Engraft Into White Adipose Tissue

    N. Sakata, G. Yoshimatsu, T. Tanaka, R. Kawakami, S. Kodama

    Department of Regenerative Medicine and Transplantation, Fukuoka University, Fukuoka, Japan

    *Purpose: While islet transplantation is recognized as a promising therapeutic option for severe diabetes mellitus (DM), especially type 1 DM, it still faces to various…
  • 2020 American Transplant Congress

    Total Pancreatectomy with Islet Autotransplantation in Diabetic and Prediabetic Patients with Intractable Chronic Pancreatitis

    P. J. Bachul1, D. J. Grybowski1, R. Anteby2, L. Basto1, L. Perea1, K. Golab1, L. Wang1, M. Tibudan1, A. Perez-Gutierrez1, M. Komorniczak3, S. Nagpal4, A. Lucander1, P. Borek1, M. Dimitrov1, J. Fung1, J. B. Matthews1, P. Witkowski1

    1Surgery, University of Chicago, Chicago, IL, 2Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 3Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland, 4Medicine, University of Chicago, Chicago, IL

    *Purpose: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment option for non-diabetic patients with intractable chronic pancreatitis. The outcome and potential benefits for…
  • 2020 American Transplant Congress

    High Laminin Alpha 5 Expression is Observed in the Pancreas of Chronic Pancreatitis Patients and Correlates with Poor Autologous Islet Transplant Outcome

    Y. Liu, K. Kumano, S. Vasu, C. M. Darden, M. Lawrence, B. Naziruddin

    Baylor University Medical Ctr, Dallas, TX

    *Purpose: During chronic pancreatitis (CP), the extracellular matrix (ECM) of the pancreas is destroyed by a vicious cycle of parenchymal autodigestion by digestive exocrine enzymes…
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