Articles tagged "Islets"

2022 American Transplant Congress
Pancreatic Islets Engineered with Thrombomodulin Show Enhanced Engraftment in an Intraportal Transplantation Model by Mitigating Instant Blood-Mediated Inflammatory Reactions
A. Turan¹, L. Zhang², M. Tarique², V. Ulker², E. Yolcu³, H. Shirwan³
¹Molecular Microbiology and Immunology, University of Missouri at Columbia, Columbia, MO, ²Department of Child Health, University of Missouri at Columbia, Columbia, MO, ³Child Health and Molecular Microbiology and Immunology, University of Missouri at Columbia, Columbia, MO
*Purpose: IBMIR is a major culprit of early islet loss post-transplant. Thrombomodulin (TM) is an anti-coagulant and cofactor of activated Protein C (APC) that perpetuates…
2022 American Transplant Congress
Smartphone-Microfluidic Fluorescence Imaging System for Studying Islet Physiology
X. Yu, Y. Xing, Y. Zhang, P. Zhang, Y. He, M. K. Ramasubramanian, Y. Wang, H. Ai, J. Oberholzer
University of Virginia, Charlottesville, VA
*Purpose: The goal of this study is to develop an innovative smartphone-microfluidic fluorescence imaging (µSFI) system for multi-parameter islet function characterization, which could provide quantitative…
2022 American Transplant Congress
Long-Term Insulin Independence Achieved by a Multimodal Approach to Beta-Cell Replacement in Patients with Type I Diabetes
M. Nunez¹, S. Wisel², J. Gardner³, G. Worner⁴, G. Roll⁵, S. Syed³, G. Szot¹, M. Tavakol¹, K. Johnson¹, A. Posselt⁴, P. Stock⁶
¹Surgery, University of California, San Francisco, San Francisco, CA, ²Cedars-Sinai Medical Center, Los Angeles, CA, ³University of California, San Francisco, San Francisco, CA, ⁴University of California San Francisco, San Francisco, CA, ⁵UCSF Medical Center, San Francisco, CA, ⁶Univ of California-San Francisco, San Francisco, CA
*Purpose: Long-term insulin independence in beta-cell replacement, via islet or pancreas transplant, remains limited by the toxic effects of calcineurin inhibitors (CNI) on beta cells…
2022 American Transplant Congress
Voxelated Bioprinting of Mechanically Robust Multiscale Porous Scaffolds for Islet Transplantation
J. Zhu, Y. He, Y. Wang, J. Oberholzer, L. Cai
University of Virginia, Charlottesvle, VA
*Purpose: Classical microencapsulation technologies for islet transplantation faces two major challenges associated with individual microcapsules. First, due to long-term gravity individual microcapsules often aggregate to…
2022 American Transplant Congress
Toll-Like Receptor-4 Inhibitor, Resatorvid, Attenuates Allogenic T Cell Activation Against Human Pancreatic Islets by Decreasing CD69 Expression
J. Mattke¹, M. Plunk¹, R. R. Kane¹, B. Naziruddin²
¹Baylor University, Waco, TX, ²Baylor University Medical Ctr, Dallas, TX
*Purpose: Allogenic and autoimmune response against islets remain major obstacles to improve long term function of islet transplants. Inhibition of toll-like receptor 4 (TLR4) using…
2022 American Transplant Congress
Characterization of Activated Islet Proliferating Cells (AIPCs) During Maturation to Pseudo-Islets
Y. Garciafigueroa, J. B. Pollett, N. Thai, R. Bottino
Imagine Pharma, Pittsburgh, PA
*Purpose: We have previously described a novel population of cells developed from human islets called AIPCs (Activated Islet Proliferating Cells). AIPCs co-express CD133, glucagon and…
2022 American Transplant Congress
Intra Portal Islet Auto Transplantation (IAT) Independently Improves Quality of Life in Patients After Total Pancreatectomy (TP) and IAT in Patients with Chronic Refractory Pancreatitis
S. Chinnakotla, G. Beilman, D. Vock, M. Freeman, V. Kirchner, T. Pruett, S. Amateau, G. Trikudanathan, E. Downs, S. Schwarzenberg, M. Armfield, K. Ramanathan, D. Sutherland, M. Bellin
University of Minnesota Medical School, Minneapolis, MN
*Purpose: TPIAT is utilized for intractable chronic-pancreatitis (CP).TP removes the source of pain and the addition of an islet auto transplant (IAT) minimizes the risk…
2022 American Transplant Congress
Preclinical Evaluation of Functional Survival of Stem Cell Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression
M. C. Poznansky
Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestwon, MA
*Purpose: Human stem cell-derived islet-like cells (SC-islets) represent a sustainable source for beta-cell replacement to achieve a functional cure for type 1 diabetes. We previously…
2022 American Transplant Congress
Islet-Derived Exosomes Carry Self-Antigens and May Induce Autoimmunity After Transplantation
S. Vasu¹, C. Darden², J. Mattke², Y. Liu³, M. C. Lawrence³, B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Baylor University, Waco, TX, ³Baylor University Medical Center, Dallas, TX
*Purpose: Our earlier observations revealed release of exosomes from human islets containing microRNAs (miRNA) specific to islet stress and damage in vitro and in vivo…
2022 American Transplant Congress
Association of Circulating microRNAs with Fibrosis and Metabolic Outcomes in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy with Islet Autotransplantation
S. Vasu¹, G. Saracino², Y. Liu², J. Mattke³, C. Darden³, M. C. Lawrence², B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Baylor University Medical Center, Dallas, TX, ³Baylor University, Waco, TX
*Purpose: In patients with Chronic Pancreatitis (CP), specific microRNAs (miRNA) were elevated in circulation before, during islet infusion and after TPIAT. We selected a panel…