2020 American Transplant Congress
Splenectomy Impedes B Cell Infiltration Associated with Rejection of Neonatal Porcine Islet Xenografts
*Purpose: Xenotransplantation has historically been frustrated by antibody-mediated rejection. Splenectomy has shown efficacy in mediating humoral immunity. We hypothesized that adding splenectomy to a clinically…2020 American Transplant Congress
The Pleural Cavity, A Novel and Clinically Relevant Site for Pancreatic Islet Transplantation
*Purpose: Islet transplantation currently provides a cure for type 1 diabetes. Hepatic infusion of islets via the portal vein is clinically accepted in human, although…2020 American Transplant Congress
Coagulation and Cd46 Transgene Modification in Neonatal Porcine Islet Xenotransplantation
Surgery, Duke University, Durham, NC
*Purpose: Vascular thrombosis is a potential cause for early intraportal xeno-islet loss. To better understand the relationship between coagulation and inflammation in early xeno-islet transplantation,…2020 American Transplant Congress
Withaferin A Prolongs Islet Allograft Survival in a Mouse Transplant Model by Preventing T Lymphocyte Proliferation and Dendritic Cell Maturation
*Purpose: Chronic decline in islet graft function and toxicities imposed by immunosuppressant drugs remain as challenges to the widespread use of islet transplantation for type…2020 American Transplant Congress
Immunomodulation with FasL Presenting Biomaterials Achieves Long-Term Survival of Allogeneic Islets in the Absence of Chronic Immunosuppression in a Non-Human Primate Model
*Purpose: The full potential of islet transplantation will only be realized by the development of tolerogenic strategies that obviate the need for maintenance immunosuppressants. We…2020 American Transplant Congress
LacripepTM and its Analogs Act as Novel Interventional Agents to Promote Long-Term Islet Transplantation Outcomes
*Purpose: To study the prosecretory, prosurvival, and mitogenic effect of Lacripep™ and its analogs in enhancing islet viability, increasing insulin secretion and promoting long-term islet…2020 American Transplant Congress
Long-term Functional Survival of Human Stem Cell-Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression
*Purpose: Human pluripotent stem cell-derived islet-like cells (SC-islets) represent a practical source for beta-cell replacement to achieve a functional cure for type 1 diabetes. Long-term…2020 American Transplant Congress
XIAP Enhances Xenoislet Survival: Novel Models to Evaluate Pretransplantation Gene Modifications
*Purpose: Porcine islet xenotransplantation offers a reliable and near limitless supply of islets for the treatment of type 1 diabetes. Intraportal infusion of cells exposes…2020 American Transplant Congress
Immune Checkpoint PD-L1 Pathway as an Effective Platform for Localized Immunomodulation to Attain Indefinite Allogeneic Islet Graft Survival
*Purpose: Allogenic islet transplantation is an effective therapeutic approach for the treatment of T1D. However, chronic immunosuppression to control rejection is a major limitation. The…2020 American Transplant Congress
Circulating MicroRNA Signatures in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy with Islet Transplantation
Baylor University Medical Ctr, Dallas, TX
*Purpose: Chronic pancreatitis (CP) is characterized by exocrine insufficiency and severe abdominal pain. Total pancreatectomy with islet autotransplantation (TPIAT) relieves chronic pain and aids restoration…
American Transplant Congress abstracts