2021 American Transplant Congress
Psychosocial Outcomes 1-year Post Total Pancreatectomy and Autologous Islet Cell Transplant
*Purpose: A paucity of research regarding the psychosocial outcomes after-total pancreatectomy and autologous islet cell transplantation exists. The aim of the study was to examine…2021 American Transplant Congress
Diffuse Calcification Pattern in Chronic Pancreatitis Has Two Aspects in Total Pancreatectomy with Islet Autotransplantation: Bad Sign for Islet Graft Function and Good Sign for Pain Relief
Baylor University Medical Ctr, Dallas, TX
*Purpose: Chronic pancreatitis (CP) is characterized by progressive inflammation and fibrosis of the pancreas. The diagnosis of CP is based on pancreatic calcifications, ductal dilatation,…2021 American Transplant Congress
Comparative Outcomes of TPIAT in African American and Caucasian Patients with Chronic Pancreatitis
Virginia Commonwealth University, Richmond, VA
*Purpose: Total pancreatectomy with islet auto-transplantation (TPIAT) is becoming the standard of care for patients with chronic pancreatitis, as it provides pain relief and improved…2021 American Transplant Congress
TPIAT Outcomes in Diabetic and Non-diabetic Patients
Virginia Commonwealth University, Richmond, VA
*Purpose: Total pancreatectomy with islet auto-transplant (TPIAT) has become a mainstay treatment for patients who suffer from refractory chronic pancreatitis. It has consistently been shown…2021 American Transplant Congress
Endocrine Cell Identity and HOMA-B In Patients with Chronic Pancreatitis Undergoing Islet Auto-transplantation
1Surgery, Houston Mehodist Hospital, Houston, TX, 2Surgery, Houston Mehodist, Houston, TX
*Purpose: Islet identity loss is an emergent factor in dysglycemia in diabetes, islet transplantation, and chronic pancreatitis (CP). Pancreatectomy and islet auto-transplantation (PIAT) for CP…2021 American Transplant Congress
Bone Marrow-Derived Mesenchymal Stem Cells Improve Rat Islet Graft Revascularization by Upregulating Isl1
Kidney Transplantation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi An, China
*Purpose: Revascularization of the transplant islet is a crucial step that defines the success rate of patient recovery. Though bone marrow-derived mesenchymal stem cells (BMSCs)…2021 American Transplant Congress
A Small Molecule Inhibitor of Toll-like Receptor-4 TAK-242 Attenuates IBMIR Against Human Islets
1Baylor University Medical Ctr, Dallas, TX, 2Baylor University, Waco, TX
*Purpose: A large portion of grafted islets are lost shortly after infusion due to the instant blood mediated inflammatory reaction (IBMIR). In our previous studies,…2021 American Transplant Congress
LacripepTM-like Peptide N-104 Increases Insulin Secretion and Promotes Islet Transplantation Outcomes
University of Virginia Health System, Charlottesville, VA
*Purpose: To study if LacripepTM-like peptide N-104 promotes beta-cell stabilization and islet transplantation outcomes. Background: Lacritin is a multifunctional tear protein with prosecretory, prosurvival and…2021 American Transplant Congress
Islet Isograft Transplantation Improves Insulin Sensitivity in a Murine Model of Type 2 Diabetes
Asan Medical Center, Seoul, Songpa, Korea, Republic of
*Purpose: Type 2 diabetes develops in the presence of chronic overnutrition and genetic susceptibility, and causes insulin resistance and relative insulin deficiency. We hypothesized that…2021 American Transplant Congress
LacripepTM-like Peptide N-104 Promotes Beta Cell Proliferation in Murine Pancreatic Islets
University of Virginia Health System, Charlottesville, VA
*Purpose: To monitor time-dependent cellular changes, with emphasis on beta cell regeneration, in pancreatic islets following treatment with LacripepTM-like peptide N-104 by mass cytometry. Background:…
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