ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Islets"

  • 2021 American Transplant Congress

    Islet Allotransplantation Into Pre-vascularized Sernova Cell PouchTM – Preliminary Results from the University of Chicago

    P. J. Bachul1, P. E. Borek1, G. S. Generette1, A. Perez-Gutierrez1, K. Jayant1, K. Golab1, L. Basto1, L. Perea1, M. Tibudan1, C. Thomas2, L. Philipson2, J. Fung1, P. Witkowski1

    1Surgery, University of Chicago, Chicago, IL, 2Medicine, University of Chicago, Chicago, IL

    *Purpose: Previous first-in-human pilot study showed safety but the conditions did not allow for detectable islet function post-transplantation into the pre-vascularized Sernova Cell Pouches (SCPs)…
  • 2021 American Transplant Congress

    Evaluation of Preperitoneal Space as an Extrahepatic Transplant Site in Clinical Total Pancreatectomy with Islet Autotransplantation

    K. Kumano, B. Naziruddin, S. Bruer, G. Saracino, M. Lawrence, G. Testa, A. Gupta, E. Beecherl, N. Onaca

    Baylor University Medical Ctr, Dallas, TX

    *Purpose: Total pancreatectomy and intraportal islet autotransplantation (TPIAT) is an effective treatment for patients with refractory chronic pancreatitis. Large volume islet preparations cannot always be…
  • 2021 American Transplant Congress

    Donor Mhc-independent Islet Rejection in Autoimmune Diabetes: Implications for Stem Cell Therapy

    R. G. Gill1, M. Coulombe2, K. S. Beard1, A. L. Burrack3

    1University of Colorado, Aurora, CO, 2Surgery, University of Colorado, Aurora, CO, 3Mircrobiology and Immunology, University of Minnesota, Minneapolis, MN

    *Purpose: Stem cell technology is an attractive approach for generating insulin-producing cells for transplantation in insulin-dependent diabetes and potentially can be genetically modified. One recent…
  • 2021 American Transplant Congress

    Targeting Calcineurin/nfatc2 Signaling to Restore Pancreatic Beta-cell Function in Islet Transplantation

    C. Darden1, J. Mattke1, S. Vasu1, K. Kumano1, Y. Liu1, B. Naziruddin2, M. C. Lawrence1

    1Baylor University Medical Ctr, Dallas, TX, 2Baylor University Medical Ctr, Allen, TX

    *Purpose: Pancreatic beta cells dedifferentiate upon exposure to metabolic and inflammatory stress characterized by loss of beta-cell identity genes, expression of beta-cell disallowed genes, and…
  • 2021 American Transplant Congress

    Exosomal DAMP Proteins Released During Islet Isolation Affects TPIAT Outcomes

    P. Saravanan, J. Kalivarathan, M. Levy, M. Kanak

    Hume Lee Islet Cell Transplantation Lab, Department of Surgery, VCU Health, Richmond, VA

    *Purpose: Isolation of islets cause significant stress that results in the release of immunogenic factors called damage-associated molecular patterns (DAMPs) which can induce inflammatory signaling…
  • 2021 American Transplant Congress

    LacripepTM-like Peptide N-104 Promotes Beta Cell Proliferation in Murine Pancreatic Islets

    M. Ma, P. Chhabra, K. Fread, K. Dias Teixeira, G. Laurie, K. Brayman

    University of Virginia Health System, Charlottesville, VA

    *Purpose: To monitor time-dependent cellular changes, with emphasis on beta cell regeneration, in pancreatic islets following treatment with LacripepTM-like peptide N-104 by mass cytometry. Background:…
  • 2021 American Transplant Congress

    Islet Isograft Transplantation Improves Insulin Sensitivity in a Murine Model of Type 2 Diabetes

    S. Lim, M. Choi, M. Kim, Y. Wee, H. Kwon, C. Jung, Y. Kim, D. Han, S. Shin

    Asan Medical Center, Seoul, Songpa, Korea, Republic of

    *Purpose: Type 2 diabetes develops in the presence of chronic overnutrition and genetic susceptibility, and causes insulin resistance and relative insulin deficiency. We hypothesized that…
  • 2021 American Transplant Congress

    LacripepTM-like Peptide N-104 Increases Insulin Secretion and Promotes Islet Transplantation Outcomes

    M. Ma, P. Chhabra, K. Dias Teixeira, G. Laurie, K. Brayman

    University of Virginia Health System, Charlottesville, VA

    *Purpose: To study if LacripepTM-like peptide N-104 promotes beta-cell stabilization and islet transplantation outcomes. Background: Lacritin is a multifunctional tear protein with prosecretory, prosurvival and…
  • 2021 American Transplant Congress

    A Small Molecule Inhibitor of Toll-like Receptor-4 TAK-242 Attenuates IBMIR Against Human Islets

    J. Mattke1, S. Vasu1, K. Kumano1, Y. Liu1, C. M. Darden1, M. C. Lawrence1, R. R. Kane2, B. Naziruddin1

    1Baylor University Medical Ctr, Dallas, TX, 2Baylor University, Waco, TX

    *Purpose: A large portion of grafted islets are lost shortly after infusion due to the instant blood mediated inflammatory reaction (IBMIR). In our previous studies,…
  • 2021 American Transplant Congress

    Bone Marrow-Derived Mesenchymal Stem Cells Improve Rat Islet Graft Revascularization by Upregulating Isl1

    W. Ying, J. Wang, X. Ding

    Kidney Transplantation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi An, China

    *Purpose: Revascularization of the transplant islet is a crucial step that defines the success rate of patient recovery. Though bone marrow-derived mesenchymal stem cells (BMSCs)…
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