Articles tagged "Islets"

2022 American Transplant Congress
Smartphone-Microfluidic Fluorescence Imaging System for Studying Islet Physiology
X. Yu, Y. Xing, Y. Zhang, P. Zhang, Y. He, M. K. Ramasubramanian, Y. Wang, H. Ai, J. Oberholzer
University of Virginia, Charlottesville, VA
*Purpose: The goal of this study is to develop an innovative smartphone-microfluidic fluorescence imaging (µSFI) system for multi-parameter islet function characterization, which could provide quantitative…
2022 American Transplant Congress
Long-Term Insulin Independence Achieved by a Multimodal Approach to Beta-Cell Replacement in Patients with Type I Diabetes
M. Nunez¹, S. Wisel², J. Gardner³, G. Worner⁴, G. Roll⁵, S. Syed³, G. Szot¹, M. Tavakol¹, K. Johnson¹, A. Posselt⁴, P. Stock⁶
¹Surgery, University of California, San Francisco, San Francisco, CA, ²Cedars-Sinai Medical Center, Los Angeles, CA, ³University of California, San Francisco, San Francisco, CA, ⁴University of California San Francisco, San Francisco, CA, ⁵UCSF Medical Center, San Francisco, CA, ⁶Univ of California-San Francisco, San Francisco, CA
*Purpose: Long-term insulin independence in beta-cell replacement, via islet or pancreas transplant, remains limited by the toxic effects of calcineurin inhibitors (CNI) on beta cells…
2022 American Transplant Congress
Voxelated Bioprinting of Mechanically Robust Multiscale Porous Scaffolds for Islet Transplantation
J. Zhu, Y. He, Y. Wang, J. Oberholzer, L. Cai
University of Virginia, Charlottesvle, VA
*Purpose: Classical microencapsulation technologies for islet transplantation faces two major challenges associated with individual microcapsules. First, due to long-term gravity individual microcapsules often aggregate to…
2022 American Transplant Congress
Toll-Like Receptor-4 Inhibitor, Resatorvid, Attenuates Allogenic T Cell Activation Against Human Pancreatic Islets by Decreasing CD69 Expression
J. Mattke¹, M. Plunk¹, R. R. Kane¹, B. Naziruddin²
¹Baylor University, Waco, TX, ²Baylor University Medical Ctr, Dallas, TX
*Purpose: Allogenic and autoimmune response against islets remain major obstacles to improve long term function of islet transplants. Inhibition of toll-like receptor 4 (TLR4) using…
2022 American Transplant Congress
Characterization of Activated Islet Proliferating Cells (AIPCs) During Maturation to Pseudo-Islets
Y. Garciafigueroa, J. B. Pollett, N. Thai, R. Bottino
Imagine Pharma, Pittsburgh, PA
*Purpose: We have previously described a novel population of cells developed from human islets called AIPCs (Activated Islet Proliferating Cells). AIPCs co-express CD133, glucagon and…
2021 American Transplant Congress
Lacripep^TM-like Peptide N-104 Increases Insulin Secretion and Promotes Islet Transplantation Outcomes
M. Ma, P. Chhabra, K. Dias Teixeira, G. Laurie, K. Brayman
University of Virginia Health System, Charlottesville, VA
*Purpose: To study if LacripepTM-like peptide N-104 promotes beta-cell stabilization and islet transplantation outcomes. Background: Lacritin is a multifunctional tear protein with prosecretory, prosurvival and…
2021 American Transplant Congress
A Small Molecule Inhibitor of Toll-like Receptor-4 TAK-242 Attenuates IBMIR Against Human Islets
J. Mattke¹, S. Vasu¹, K. Kumano¹, Y. Liu¹, C. M. Darden¹, M. C. Lawrence¹, R. R. Kane², B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Baylor University, Waco, TX
*Purpose: A large portion of grafted islets are lost shortly after infusion due to the instant blood mediated inflammatory reaction (IBMIR). In our previous studies,…
2021 American Transplant Congress
Bone Marrow-Derived Mesenchymal Stem Cells Improve Rat Islet Graft Revascularization by Upregulating Isl1
W. Ying, J. Wang, X. Ding
Kidney Transplantation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi An, China
*Purpose: Revascularization of the transplant islet is a crucial step that defines the success rate of patient recovery. Though bone marrow-derived mesenchymal stem cells (BMSCs)…
2021 American Transplant Congress
Endocrine Cell Identity and HOMA-B In Patients with Chronic Pancreatitis Undergoing Islet Auto-transplantation
C. A. Beamish¹, O. Gaber², O. M. Sabek²
¹Surgery, Houston Mehodist Hospital, Houston, TX, ²Surgery, Houston Mehodist, Houston, TX
*Purpose: Islet identity loss is an emergent factor in dysglycemia in diabetes, islet transplantation, and chronic pancreatitis (CP). Pancreatectomy and islet auto-transplantation (PIAT) for CP…
2021 American Transplant Congress
TPIAT Outcomes in Diabetic and Non-diabetic Patients
M. A. Kanak, J. B. Spriggs, P. Coughenour, J. Kalivarathan, P. Saravanan, M. Levy
Virginia Commonwealth University, Richmond, VA
*Purpose: Total pancreatectomy with islet auto-transplant (TPIAT) has become a mainstay treatment for patients who suffer from refractory chronic pancreatitis. It has consistently been shown…