2022 American Transplant Congress
Intra Portal Islet Auto Transplantation (IAT) Independently Improves Quality of Life in Patients After Total Pancreatectomy (TP) and IAT in Patients with Chronic Refractory Pancreatitis
University of Minnesota Medical School, Minneapolis, MN
*Purpose: TPIAT is utilized for intractable chronic-pancreatitis (CP).TP removes the source of pain and the addition of an islet auto transplant (IAT) minimizes the risk…2022 American Transplant Congress
Preclinical Evaluation of Functional Survival of Stem Cell Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression
Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestwon, MA
*Purpose: Human stem cell-derived islet-like cells (SC-islets) represent a sustainable source for beta-cell replacement to achieve a functional cure for type 1 diabetes. We previously…2022 American Transplant Congress
Islet-Derived Exosomes Carry Self-Antigens and May Induce Autoimmunity After Transplantation
*Purpose: Our earlier observations revealed release of exosomes from human islets containing microRNAs (miRNA) specific to islet stress and damage in vitro and in vivo…2022 American Transplant Congress
Association of Circulating microRNAs with Fibrosis and Metabolic Outcomes in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy with Islet Autotransplantation
*Purpose: In patients with Chronic Pancreatitis (CP), specific microRNAs (miRNA) were elevated in circulation before, during islet infusion and after TPIAT. We selected a panel…2022 American Transplant Congress
Spleen-Preserving Total Pancreatectomy with Islet Autotransplantation with Complete Preservation of the Splenic Arterial and Venous Supply Does Not Impact Islet Yield and Function
Baylor University Medical Center, Dallas, TX
*Purpose: Typically, Total Pancreatectomy with Islet Autotransplantation (TPIAT) includes splenectomy. Spleen sparing TPIAT was described in the literature using the Warshaw technique, with proximal ligation…2021 American Transplant Congress
TPIAT Outcomes in Diabetic and Non-diabetic Patients
Virginia Commonwealth University, Richmond, VA
*Purpose: Total pancreatectomy with islet auto-transplant (TPIAT) has become a mainstay treatment for patients who suffer from refractory chronic pancreatitis. It has consistently been shown…2021 American Transplant Congress
Comparative Outcomes of TPIAT in African American and Caucasian Patients with Chronic Pancreatitis
Virginia Commonwealth University, Richmond, VA
*Purpose: Total pancreatectomy with islet auto-transplantation (TPIAT) is becoming the standard of care for patients with chronic pancreatitis, as it provides pain relief and improved…2021 American Transplant Congress
Diffuse Calcification Pattern in Chronic Pancreatitis Has Two Aspects in Total Pancreatectomy with Islet Autotransplantation: Bad Sign for Islet Graft Function and Good Sign for Pain Relief
Baylor University Medical Ctr, Dallas, TX
*Purpose: Chronic pancreatitis (CP) is characterized by progressive inflammation and fibrosis of the pancreas. The diagnosis of CP is based on pancreatic calcifications, ductal dilatation,…2021 American Transplant Congress
Psychosocial Outcomes 1-year Post Total Pancreatectomy and Autologous Islet Cell Transplant
*Purpose: A paucity of research regarding the psychosocial outcomes after-total pancreatectomy and autologous islet cell transplantation exists. The aim of the study was to examine…2021 American Transplant Congress
Two Hundred Total Pancreatectomy with Islet Autotransplantation Cases: A Single Center Experience
1Baylor University Medical Ctr, Dallas, TX, 2Virginia Commonwealth University, Richmond, VA
*Purpose: Total pancreatectomy and islet autotransplantation (TPIAT) for patients with uncontrolled chronic pancreatitis has been performed at our center from 2006 and the number of…
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