Articles tagged "Islets"

2022 American Transplant Congress
Association of Circulating microRNAs with Fibrosis and Metabolic Outcomes in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy with Islet Autotransplantation
S. Vasu¹, G. Saracino², Y. Liu², J. Mattke³, C. Darden³, M. C. Lawrence², B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Baylor University Medical Center, Dallas, TX, ³Baylor University, Waco, TX
*Purpose: In patients with Chronic Pancreatitis (CP), specific microRNAs (miRNA) were elevated in circulation before, during islet infusion and after TPIAT. We selected a panel…
2022 American Transplant Congress
Spleen-Preserving Total Pancreatectomy with Islet Autotransplantation with Complete Preservation of the Splenic Arterial and Venous Supply Does Not Impact Islet Yield and Function
M. Coluzzi, B. Naziruddin, G. Saracino, G. Testa, E. Beecherl, N. Onaca
Baylor University Medical Center, Dallas, TX
*Purpose: Typically, Total Pancreatectomy with Islet Autotransplantation (TPIAT) includes splenectomy. Spleen sparing TPIAT was described in the literature using the Warshaw technique, with proximal ligation…
2022 American Transplant Congress
The Application of Activated Stem Cells from Human Exfoliated Deciduous Teeth (SHED) in Islet Transplantation for Novel Immunosuppressive Therapy
K. Ishiyama¹, M. Kato², S. Tsunekawa², Y. Miwa¹, K. Iwasaki¹, H. Kamiya², T. Kobayashi¹
¹Division of Kidney Transplantation, Department of Surgery, Aichi Medical University, Nagakute, Japan, ²Division of Diabetes, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan
*Purpose: While various attempts have been made to improve the efficiency of islet transplantation, we have been working on the analysis of the mechanism of…
2022 American Transplant Congress
Biological Functions of Circulating miRNAs in Patients with Chronic Pancreatitis Undergoing Total Pancreatectomy with Islet Autotransplantation
S. Vasu¹, C. Darden², Y. Liu³, M. Lawrence⁴, B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Baylor University, Waco, TX, ³-Baylor University Medical Center, Dallas, TX, ⁴Baylor University Medical Center, Dallas, TX
*Purpose: Our previous reports showed that in patients with Chronic Pancreatitis (CP), specific microRNAs (miRNA) were elevated in circulation before, during islet infusion and after…
2022 American Transplant Congress
Tacrolimus Induces Dedifferentiation of Pancreatic Beta Cells by Inhibition of Calcineurin/NFATc2 and Islet Cell Differentiation Genes
C. M. Darden¹, S. Vasu², J. Mattke³, Y. Liu², B. Naziruddin⁴, M. C. Lawrence²
¹Baylor University, Dallas, TX, ²Baylor University Medical Center, Dallas, TX, ³Baylor University, Waco, TX, ⁴Baylor University Medical Ctr, Dallas, TX
*Purpose: Tacrolimus (FK506) is a potent immunosuppressant widely used for solid organ transplantation to prevent lymphokine gene expression by inhibiting calcineurin (CN) and its downstream…
2021 American Transplant Congress
Psychosocial Outcomes 1-year Post Total Pancreatectomy and Autologous Islet Cell Transplant
J. Steel¹, A. Amin¹, M. Wijkstrom¹, A. Zureikat¹, E. Tillman¹, R. Jones¹, D. Yadav¹, A. Slivka¹, A. Phillips¹, M. Bellin², A. Carroll³, A. Humar¹
¹University of Pittsburgh, Pittsburgh, PA, ²University of Minnesota, Minneapolis, MN, ³University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: A paucity of research regarding the psychosocial outcomes after-total pancreatectomy and autologous islet cell transplantation exists. The aim of the study was to examine…
2021 American Transplant Congress
Two Hundred Total Pancreatectomy with Islet Autotransplantation Cases: A Single Center Experience
K. Kumano¹, S. Bruer¹, G. Saracino¹, M. Lawrence¹, G. Testa¹, A. Gupta¹, N. Onaca¹, E. Beecherl¹, M. F. Levy², B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Virginia Commonwealth University, Richmond, VA
*Purpose: Total pancreatectomy and islet autotransplantation (TPIAT) for patients with uncontrolled chronic pancreatitis has been performed at our center from 2006 and the number of…
2021 American Transplant Congress
Islet Allotransplantation Into Pre-vascularized Sernova Cell Pouch^TM – Preliminary Results from the University of Chicago
P. J. Bachul¹, P. E. Borek¹, G. S. Generette¹, A. Perez-Gutierrez¹, K. Jayant¹, K. Golab¹, L. Basto¹, L. Perea¹, M. Tibudan¹, C. Thomas², L. Philipson², J. Fung¹, P. Witkowski¹
¹Surgery, University of Chicago, Chicago, IL, ²Medicine, University of Chicago, Chicago, IL
*Purpose: Previous first-in-human pilot study showed safety but the conditions did not allow for detectable islet function post-transplantation into the pre-vascularized Sernova Cell Pouches (SCPs)…
2021 American Transplant Congress
Evaluation of Preperitoneal Space as an Extrahepatic Transplant Site in Clinical Total Pancreatectomy with Islet Autotransplantation
K. Kumano, B. Naziruddin, S. Bruer, G. Saracino, M. Lawrence, G. Testa, A. Gupta, E. Beecherl, N. Onaca
Baylor University Medical Ctr, Dallas, TX
*Purpose: Total pancreatectomy and intraportal islet autotransplantation (TPIAT) is an effective treatment for patients with refractory chronic pancreatitis. Large volume islet preparations cannot always be…
2021 American Transplant Congress
Donor Mhc-independent Islet Rejection in Autoimmune Diabetes: Implications for Stem Cell Therapy
R. G. Gill¹, M. Coulombe², K. S. Beard¹, A. L. Burrack³
¹University of Colorado, Aurora, CO, ²Surgery, University of Colorado, Aurora, CO, ³Mircrobiology and Immunology, University of Minnesota, Minneapolis, MN
*Purpose: Stem cell technology is an attractive approach for generating insulin-producing cells for transplantation in insulin-dependent diabetes and potentially can be genetically modified. One recent…