2022 American Transplant Congress
‘Adjuvant Conditioned’ Myeloid Derived Suppressor Cells Prolong Islets Graft Survival Through IL-10 Production
*Purpose: Advances in immunosuppression have been relatively stagnant over the last 2 decades and transplant patients continue to experience morbidity associated with immunosuppression regimens. Through…2022 American Transplant Congress
Bionic Pancreas – The First Results of Functionality of 3D-Bioprinted Bionic Tissue Model Transplantation with Pancreatic Islets
*Purpose: Tissue engineering is currently on advanced stage of development which gives a possibilities for novel strategy of personal treatment of type 1 diabetes. AIM:…2022 American Transplant Congress
Utilizing Microporous Annealed Particle (MAP) Gel as an Immunomodulatory Carrier for Islet Delivery
*Purpose: To investigate if coating with MAP gel improves dissociated or whole islet transplantation outcome.*Background: MAP gel platform technology is composed of hydrogel microspheres that…2022 American Transplant Congress
Bioink Based on the DECM for 3D-Bioprinting of Bionic Pancreas – First Results of Animal
*Purpose: Tissue engineering is an interdisciplinary field involving activities based on two interrelated areas: developing new methods to repair, regenerate and replace damaged tissues and…2022 American Transplant Congress
Vitrification of Pancreatic Islets and Transplantation
1University of Minnesota, Minneapolis, MN, 2Mayo Clinic, Rochester, MN
*Purpose: A limitation to potential cure for diabetes through islet transplantation is insufficient islet equivalence (IEQ) from a single donor to achieve insulin independence in…2021 American Transplant Congress
Targeting Calcineurin/nfatc2 Signaling to Restore Pancreatic Beta-cell Function in Islet Transplantation
1Baylor University Medical Ctr, Dallas, TX, 2Baylor University Medical Ctr, Allen, TX
*Purpose: Pancreatic beta cells dedifferentiate upon exposure to metabolic and inflammatory stress characterized by loss of beta-cell identity genes, expression of beta-cell disallowed genes, and…2021 American Transplant Congress
Exosomal DAMP Proteins Released During Islet Isolation Affects TPIAT Outcomes
Hume Lee Islet Cell Transplantation Lab, Department of Surgery, VCU Health, Richmond, VA
*Purpose: Isolation of islets cause significant stress that results in the release of immunogenic factors called damage-associated molecular patterns (DAMPs) which can induce inflammatory signaling…2021 American Transplant Congress
LacripepTM-like Peptide N-104 Promotes Beta Cell Proliferation in Murine Pancreatic Islets
University of Virginia Health System, Charlottesville, VA
*Purpose: To monitor time-dependent cellular changes, with emphasis on beta cell regeneration, in pancreatic islets following treatment with LacripepTM-like peptide N-104 by mass cytometry. Background:…2021 American Transplant Congress
Islet Isograft Transplantation Improves Insulin Sensitivity in a Murine Model of Type 2 Diabetes
Asan Medical Center, Seoul, Songpa, Korea, Republic of
*Purpose: Type 2 diabetes develops in the presence of chronic overnutrition and genetic susceptibility, and causes insulin resistance and relative insulin deficiency. We hypothesized that…2021 American Transplant Congress
LacripepTM-like Peptide N-104 Increases Insulin Secretion and Promotes Islet Transplantation Outcomes
University of Virginia Health System, Charlottesville, VA
*Purpose: To study if LacripepTM-like peptide N-104 promotes beta-cell stabilization and islet transplantation outcomes. Background: Lacritin is a multifunctional tear protein with prosecretory, prosurvival and…
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