Articles tagged "Ischemia"

2015 American Transplant Congress
CD4 T Cell Mediated Help Is Required for Endogenous Memory CD8 T Cell Proliferation in Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage
H. Tsuda,^1,4 T. Tanaka,^2,4 N. Kohei,^3,4 D. Kish,⁴ W. Baldwin,⁴ A. Valujskikh,⁴ R. Fairchild.⁴
¹Advanced Technology for Transplantation, Osaka Univ., Suita, Japan; ²Urology, Sapporo Medical Univ., Sapporo, Japan; ³Urology, Tokyo Women's Medical Univ., Tokyo, Japan; ⁴Immunology, Cleveland Clinic, Cleveland, OH.
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…
2015 American Transplant Congress
Remote Ischemic Perconditioning Induces Protection Against Hepatic Ischemia/Reperfusion Injury in Rats Via Downregualtion of Bax and Cleaved Caspase-3 Expression
H. Ahn, M. Park, S. Joo, B. Kim.
Department of Surgery, Kyung Hee University, Seoul, Korea.
Purpose: The aim of this study was to determine whether remote ischemic preconditioning (rPeC) method can protect the hepatic IR injury in rat or not…
2015 American Transplant Congress
Diabetes Exacerbates Liver Ischemia and Reperfusion Injury By Activating the AGE-RAGE Pathway in Kupffer Cells
S. Yue, J. Zhu, J. Rao, J. Kupiec-Weglinski, R. Busuttil, Y. Zhai.
Surgery, UCLA, Los Angeles, CA.
Although pre-transplant diabetes has been documented as a risk factor for mortality post-liver transplant, the underlying mechanism remains obscure. In a murine liver partial warm…
2015 American Transplant Congress
Aquaporin 4 Blockade Is a Novel Strategy Targeting Ischemia/Reperfusion Injury in Heart Transplantation
K. Ayasoufi,¹ N. Kohei,¹ G. Farr,² P. McGuirk,² M. Pelletier,² R. Fairchild,¹ A. Valujskikh.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Aeromics, LLC, Cleveland, OH.
Aquaporin 4 (AQP4) belongs to the family of small integrin transmembrane proteins that are highly permeable to water. It was recently shown that human and…
2015 American Transplant Congress
Liver Flushing Using Colloid and Crystalloid Solutions
J. Burg, D. Scott, K. Enestvedt, K. Roayaie, D. Scott.
Abdominal Organ Transplantation, Oregon Health and Science University, Portland.
Background:Preservation solutions such as University of Wisconsin solution and histidine-tryptophan-ketoglutarate solution have been cited as causes of hypotension and adverse donor reactions following reperfusion of…
2015 American Transplant Congress
Role of Complement in Mediating Pericyte Trans-Differentiation in Resident Myofibroblasts: A New Hypothesis On Vascular Rarefaction in Renal Ischemia/Reperfusion (I/R) Injury
G. Castellano,¹ R. Franzin,¹ C. Divella,¹ A. Stasi,¹ A. Intini,¹ M. Gigante,¹ G. Lucarelli,¹ P. Ditonno,¹ M. Battaglia,¹ A. Crovace,¹ F. Staffieri,¹ G. Pertosa,¹ B. Oortwijn,² E. Amersfoort,² G. Grandaliano,³ L. Gesualdo.¹
¹University of Bari, Bari, Italy; ²Pharming Technologies NV, Leiden, Netherlands; ³University of Foggia, Foggia, Italy.
Vascular rarefaction is critical in the development of renal fibrosis. Pericytes regulate renal blood flow and might be an important source of renal interstitial myofibroblasts;…
2015 American Transplant Congress
Kidney Double Negative TCR αβ + Cells: Newly Described Intra-Renal Kidney Lymphocytes That Respond to Ischemia Reperfusion in Mice
M. Martina,¹ S. Bandapalle,² S. Noel,² A. Saxena,¹ A. Hamad,¹ H. Rabb.²
¹Pathology, Johns Hopkins University, Baltimore, MD; ²Medicine, Johns Hopkins University, Baltimore, MD.
Background TCRαβ+CD4-CD8- double negative (DN) T cells with immunoregulatory function are a significant component of T cells residing in the kidney. The exact role of…
2015 American Transplant Congress
Detriemental Impact of DGF and CIT On Longterm Survival After Kidney Transplantation in Elderly Recipients
C. Denecke,^1,2 M. Biebl,^1,2 C. Bösmüller,² F. Aigner,^1,2 T. Dziodzio,^1,2 R. Sucher,^1,2 S. Weiss,² J. Pratschke,^1,2 R. öllinger.^1,2
¹Allgemein, Viszeral – und Transplantationschirurgie, Charite Virchow Klinikum, Berlin, Germany; ²Viszeral, Transplantations – und Thoraxchirurgie, Medizinische Universität Innsbruck, Innsbruck, Austria.
Background: In kidney transplantation, the association of cold ischemia time (CIT) and delayed graft function (DGF) is particularly detriemental in grafts from marginal donors. In…
2015 American Transplant Congress
Mitochondrial Hydrogen Sulphide Donor Molecules Are More Effective Against Hypoxic Injury in Renal Tubular Epithelial Cells
G. Aboalsamh,^1,5 M. Saha,² I. Lobb,² J. Grewal,² P. Luke,^1,2,3 M. Wood,⁴ M. Whiteman,⁴ A. Sener.^1,2,3
¹Urology, University of Western Ontario, London, Canada; ²Microbiology and Immunology, University of Western Ontario, London, Canada; ³University of Western Ontario, University of Western Ontario, London, Canada; ⁴Experimental Therapeutics, University of Exeter Medical School, Exeter, England, United Kingdom; ⁵Surgery, King Abdulaziz Medical Center, Jeddah, Saudi Arabia.
Introduction: Ischemia reperfusion injury (IRI) in organ transplant often manifests itself as delayed graft function (DGF). DGF is associated with increased morbidity and deleterious effects…
2015 American Transplant Congress
Tandem P-Selectin Glycoprotein Ligand-Immunoglobulin (TSGL-Ig) Protects Liver Endothelial Cells Against Prolonged Cold Preservation Injury in Mouse Liver Transplantation
C. Zhang,¹ H. Ji,¹ Y. Liu,¹ X. Shen,¹ F. Gao,¹ R. Busuttil,¹ G. Shaw,² J. Kupiec-Weglinski.¹
¹Dept of Surgery, Dumont-UCLA Liver Transplant Center, Los Angeles, CA; ²Quell Pharma Inc., Half Moon Bay, CA.
Background: Liver endothelial cell (LEC) damage is central in the pathogenesis of hepatic ischemia-reperfusion injury (IRI). LEC detachment/progressed denudation are typical during cold storage and…