Articles tagged "Ischemia"

2015 American Transplant Congress
Targeting Leukocyte Integrin CD11b/CD18 With a Novel mAb Salvages Renal Function Following an Otherwise Irreversible Ischemic Insult in Cynomolgus Monkeys
A. Cosimi,¹ A. Dehnadi,¹ R. Smith,² D. Ko,¹ X. Li,³ M. Arnaout.³
¹Transplant Surgery, Massachusetts General Hospital, Boston, MA; ²Pathology, MGH, Boston, MA; ³Nephrology, MGH, Boston, MA.
Allograft dysfunction resulting from ischemic reperfusion injury (IRI) leads to increased peri-transplant costs, morbidity, and inferior long-term survival. Leukocyte/endothelial adhesion is an important pathway contributing…
2015 American Transplant Congress
Ischemia Reperfusion Injury in Orthotopic Liver Transplantation Primes the Adaptive Immune Response and Generation of Proinflammatory Cytokines
A. Zarrinpar,¹ P. Rao,² C. Lassman,² V. Agopian,¹ F. Kaldas,¹ D. Farmer,¹ R. Busuttil,¹ Y. Zhai,¹ J. Kupiec-Weglinski,¹ E. Reed.²
¹Surgery, University of California, Los Angeles, Los Angeles, CA; ²Pathology and Lab Medicine, University of California, Los Angeles, Los Angeles, CA.
Background: Transplanted organs are exquisitely susceptible to effects of ischemia/reperfusion injury (IRI), an immune-mediated process that occurs during transplantation and beyond. Recipient and graft outcomes,…
2015 American Transplant Congress
Donor Organ Resident M2 Type Myeloid Cells Protect Murine Orthotropic Liver Transplants from Ischemia and Reperfusion Injury
S. Yue, X. Shen, F. Gao, R. Busuttil, J. Kupiec-Weglinski, Y. Zhai.
The Dumont-UCLA Transplant Ctr., UCLA, Los Angeles, CA.
Liver ischemia reperfusion injury (lRI) is mediated by a pro-inflammatory immune response initiated by the activation of liver non-parenchymal innate immune cells, such as Kupffer…
2015 American Transplant Congress
The Effect of Systemic Catecholamine Application On the Microcirculation in Liver Procurement
M. Strempel,¹ M. Kaths,¹ H. Lang,¹ G. Otto,¹ V. Weyer,² O. Kempski,³ A. Heimann,³ A. Schad,⁴ D. Foltys.¹
¹Department of Transplantation and Hepatobiliopancreatic Surgery, University Medical Centre, Johannes Gutenberg-University, Mainz, Germany; ²Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg-University, Mainz, Germany; ³Institute of Neurosurgical Pathophysiology, University Medical Centre, Johannes Gutenberg-University, Mainz, Germany; ⁴Institute of Pathology, University Medical Centre, Johannes Gutenberg-University, Mainz, Germany.
Introduction: The most vulnerable part in liver transplantation remains the biliary system. There is evidence, that insufficient perfusion during multi-organ procurement plays a major role…
2015 American Transplant Congress
Rewarming of Cold Preserved Livers Decreases Graft Injury and Kupffer Cell Activation by Normothermic Extracorporeal Liver Perfusion (NELP)
B. Banan,¹ R. Watson,² Y. Lin,¹ J. Jia,¹ Z. Xiao,¹ G. Upadhya,¹ W. Chapman.¹
¹Surgery, Washington University School of Medicine, St Louis, MO; ²Anatomic & Molecular Pathology, Washington University School of Medicine, St Louis, MO.
Normothermic extracorporeal liver perfusion (NELP) is able to decrease ischemia reperfusion injury to the greatest degree when cold ischemic time is minimized. However, given the…
2015 American Transplant Congress
T Cell Specific Up Regulation of Nrf2 Regulated Antioxidant Response Protects from Kidney Ischemia Reperfusion Injury in Mice
S. Noel,¹ M. Martina,² S. Bandapalle,¹ S. Reddy,³ L. Racusen,² A. Hamad,² H. Rabb.¹
¹Department of Medicine, Johns Hopkins University, Baltimore, MD; ²Department of Pathology, Johns Hopkins University, Baltimore, MD; ³Department of Pediatrics, University of Illinois, Chicago, IL.
Background: T lymphocytes mediate important pathophysiological roles during ischemia reperfusion injury (IRI). Transcription factor Nrf2 is protective during experimental kidney IRI and thought to be…
2015 American Transplant Congress
Remote Ischemic Preconditioning Increases Transplantation of Abdominal Organs in Standard Criteria Neurological Death Donors
A. Bongu,¹ W. Washburn,² J. Oliver,¹ J. Nespral,³ A. Davidow,⁴ C. Kadric,³ G. Dikdan,¹ J. Lewis,² U. Pandit,¹ A.-K. Beidas,¹ C. Tourtellot,³ L. Brown,¹ B. Koneru.¹
¹Surgery, Rutgers-New Jersey Medical School, Newark, NJ; ²Surgery, University of Texas Health Science Center, San Antonio, TX; ³Texas Organ Sharing Alliance, San Antonio, TX; ⁴Preventive Medicine, Rutgers-New Jersey Medical School, Newark, NJ.
Background: Remote ischemic preconditioning (RIPC) induces innate protective mechanisms in remote organs. We hypothesized RIPC soon after neurological death (ND) would improve donor organ function…
2015 American Transplant Congress
Losartan Benefits Are Mediated Through SIRT1 Activation in Rat Reduced Size Orthotopic Liver Transplantation
E. Pantazi,¹ M. Bejaoui,¹ M. Zaouali,¹ E. Folch-Puy,¹ A. Rolo,^2,3 A. Panisello,¹ C. Palmeira,² J. Rosello-Catafau.¹
¹Experimental Pathology, Institute of Biomedical Research of Barcelona (IIBB-CSIC), Barcelona, Spain; ²Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal; ³Center for Neurosciences and Cell Biology, Department of Zoology, University of Coimbra, Coimbra, Portugal.
Background: Silent Information Regulator 1 (SIRT1) is a histone deacetylase that has been associated with protective mechanisms against IRI, but its role in liver transplantation…
2015 American Transplant Congress
The Liver X Receptor Alpha (LXRα) Knockout Protect Liver Against Ischemia-Reperfusin Injury in Mice
T. Lu,¹ D. Li,¹ J. Zhang,¹ M. Zhang,¹ X. Cui,¹ H. Dai,¹ X. Liu,² Q. Xia.¹
¹Liver Surgery and Liver Transplantation Center, Renji Hospital, Shanghai, China; ²Cardiovascular, Shanghai First People's Hospital, Shanghai, China.
Background: Liver X Receptor Alpha (LXRα) is a transcription factor crucial for cholesterol, fatty acid, and glucose homeostasis. We hypothesize that LXRαKO may promote hepatocellular…
2015 American Transplant Congress
Kidney and Liver CIT Variations Across OPOs and Their Implications: US Experience Between 2003 and 2011
J. Melancon, N. Koizumi, C. Callender, D. DasGupta, T. Smith.
Surgery, George Washington University, Washington, DC; Public Policy, George Mason University, Arlington, VA; Surgery, Howard University, Washington, DC; Health Sciences, University of Indianapolis, Indianapolis, IN; School of Engineering, University of Pennsylvania, Philadelphia, PA.
Introduction: Significant variations in kidney and liver transplant outcomes across OPOs have been reported, but their causes remain largely unknown. This study investigated variations in…