Articles tagged "Ischemia"

2021 American Transplant Congress
Glycogen Synthase Kinase 3 Beta Regulates Distinctive Macrophage Subsets in the Activation and Resolution of Liver Ischemia Reperfusion Injury
H. Zhang¹, M. Ni², J. Zhang¹, H. Wang², R. Busuttil¹, J. Kupiec-Weglinski¹, Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Glycogen synthase kinase 3β (Gsk3β) differentially regulates pro- and anti-inflammatory programs in macrophages upon TLR stimulations. We have documented in a murine liver partial…
2021 American Transplant Congress
Proxies of Ischemia Time Do Not Predict 1-Year Posttransplant Survival
M. Skeans¹, A. Wey¹, E. Lease², C. Lehr³, J. Alcorn⁴, R. Goff⁴, D. Stewart⁴, M. Valapour³
¹SRTR, Minneapolis, MN, ²Univ of Washington, Seattle, WA, ³Cleveland Clinic, Cleveland, OH, ⁴UNOS, Richmond, VA
*Purpose: A barrier to broader distribution of donor organs is a concern that increased donor-to-recipient (DtR) distances could increase ischemia times and compromise posttransplant (PT)…
2021 American Transplant Congress
The Inflammatory Response in the Context of Tissue Injury: Roles of Tyro3, Axl, and Mer (TAM) Receptor Tyrosine Kinases in Liver Ischemia/reperfusion Injury
J. Zhang¹, H. Zhang¹, M. Ni², R. Busuttil¹, J. Kupiec-Weglinski¹, Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Liver Suyrgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Although the inflammatory response in liver ischemia reperfusion injury has been studied extensively, how the context of tissue injury (presence of necrotic/apoptotic cells) regulates…
2021 American Transplant Congress
Successful Long Term Survival of Vascularized Composite Allografts After Extended Preservation at Subzero Temperatures Using Bioinspired Next Generation Cryoprotectants
M. Kline¹, S. Fidder², A. Callegari¹, A. Matoso², B. Oh², K. Lombardo², J. Etra², D. Vasilic³, A. Childs¹, R. Redett², G. Brandacher², X. Wei¹
¹X-Therma Inc., Richmond, CA, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Erasmus MC, Rotterdam, Netherlands
*Purpose: Vascularized composite allotransplantation (VCA) is a viable reconstructive option for patients with devastating tissue defects. However, the field is constrained by short tolerable ischemia…
2021 American Transplant Congress
Myeloid Yap Signaling is Required for Hepatic Cytoprotection in Liver Ischemia-reperfusion Injury
B. Yang¹, Z. Xue¹, C. Zhang², Y. Zhang², Y. Liu², J. Kupiec-Weglinski¹, H. Ji¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Dept of Surgery, Zhejiang University, Hangzhou, China
*Purpose: Liver ischemia-reperfusion injury (IRI) is recognized as an innate immunity-driven local inflammation response during hemorrhagic shock, liver resection and transplantation. Yes-associate protein 1 (YAP)…
2021 American Transplant Congress
Estrogen Receptor Beta Deletion is Protective in Renal Ischemia Reperfusion Injury in a Renal Specific Manner
C. S. O'Brien, P. Hernandez, Z. Wang, G. Ge, W. Hancock, M. H. Levine
Surgery, University of Pennsylvania, Philadelphia, PA
*Purpose: Renal Ischemia Reperfusion Injury (IRI) is a major contributor to delayed graft function (DGF) in kidney transplantation. Previously, we have shown lower rates of…
2021 American Transplant Congress
Galectin-3 Blockade Can Decrease Reperfusion Injury in Response to Ischemia in a Rat Hind Limb Transplant Model
Z. Wang¹, Y. Wang¹, D. Yoeli¹, B. Li¹, A. Su¹, D. Mathes¹, K. Washington¹, E. Farkash², C. A. Huang¹
¹University of Colorado, Aurora, CO, ²University of Michigan, Ann Arbor, Ann Arbor, MI
*Purpose: Vascularized composite allograft (VCA) transplant is technically feasible and results in successful clinical outcomes. However, skin and muscle containing VCA is highly susceptible to…
2021 American Transplant Congress
Eosinophils Attenuate Hepatic Ischemia Reperfusion Injury in Mice Through St2-Dependent Il-13 Production
Y. Yang, Y. Wang, M. Wang, J. Jeong, L. Xu, Y. Wen, C. Emontzpohl, W. Dar, C. Ju
Department of Anesthesiology, McGovern Medical School University of Texas Health Science Center at Houston, Houston, TX
*Purpose: The purpose is to investigate the functional role of eosinophils during hepatic ischemia and reperfusion injury (IRI).*Methods: Mice with antibody-induced eosinophil depletion and two…
2021 American Transplant Congress
Mitochondrial Transplant Minimizes Liver Ischemia Reperfusion Injury in Lean and Obese Mice
C. Watkins¹, G. Lamanilao¹, C. Kuscu¹, C. Kuscu¹, J. F. Pierre², J. Eason¹, A. Bajwa¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ²Department of Pediatrics - Divisions of Neonatology and Pediatric Obesity, The University of Tennessee Health Science Center, Memphis, TN
*Purpose: Ischemia induces altered bioenergetics within cells with increased mitochondrial swelling and reactive oxygen species and that ultimately degrade of cellular function. Ischemia reperfusion injury…
2021 American Transplant Congress
Double Negative T Cells Mediate Cd39-Dependent Protection in Hepatic Ischemia and Reperfusion Injury
H. Jin, M. Li, C. Zhang, G. Sun, D. Zhang
Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China
*Purpose: Hepatic ischemia and reperfusion injury (HIRI) is a significant cause of morbidity and mortality following liver transplantation and major hepatic resections. Double negative T…

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