ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Ischemia"

  • 2020 American Transplant Congress

    Donor Intervention and Recipient Treatment with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function in a Non-Human Primate Model of Kidney Transplantation

    J. A. Reyes1, C. Blanton1, M. Eerhart1, P. Chlebeck1, M. Springer1, Y. Ponstein2, E. van Amersfoort2, J. Torrealba3, Y. Yankol1, A. D'Allessandro1, L. Fernandez1

    1Surgery, University of Wisconsin, Madison, WI, 2Pharming Technologies BV, Leiden, Netherlands, 3Pathology, UT Soutwestern, Dallas, TX

    *Purpose: There is currently no FDA-approved treatment to prevent delayed graft function (DGF) in kidney transplantation. We have shown that donor or recipient treatment with…
  • 2020 American Transplant Congress

    The Significance of Donor Gender on Graft Survival and Histological Ischemia Reperfusion Injury in Liver Transplant Patients

    T. Ito, S. Kageyama, K. J. Dery, K. Nakamura, S. M. Younan, M. M. Lu, J. DiNorcia III, V. G. Agoian, H. Yersis, D. G. Farmer, R. W. Busuttil, F. M. Kaldas

    Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA

    *Purpose: Experimental animal models have demonstrated improved ability of females (F) to recover from ischemia-reperfusion injury (IRI) compared with males (M). Recent work combining human…
  • 2020 American Transplant Congress

    Treprostinil is Safe and Potentially Useful in Preventing Ischemia and Reperfusion Injury in Adult Orthotopic Liver Transplant Recipients

    R. Venkataramanan1, I. H. Shaik2, V. C. Pillai3, O. A. Almazroo4, M. K. Miah5, R. Xu2, S. Dharmayan2, A. Al-Khafaji2, S. Ganesh2, M. Molinari2, A. Tevar2, C. Hughes2, A. Humar2

    1School Of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA, 3US Food and Drug Administration,, Silver Spring, MD, 4Saudi FDA, Riyadh, Saudi Arabia, 5Astra Zeneca, Boston, MA

    *Purpose: Ischemia and reperfusion injury (IRI) is one of the unavoidable complications in orthotopic liver transplantion. Hepatic ischemic injury begins during the preservation of the…
  • 2020 American Transplant Congress

    Prolonged Cold Ischemia Increases Reactive Oxygen Species Activates Autophagy by Enhancing Glycolysis in the Graft Through the mTOR Signaling Pathway in Orthotopic Lung Transplantation of Rats

    H. Lin1, S. Dai2, W. Liu3, X. Lin2, B. Yu2, S. Chen3, S. Liu2, J. Tang2

    1Thoracic Surgery, Wuhan University, Renmin Hospital, Wuhan, China, 2Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China, 3Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China

    *Purpose: The aim of the present study is to investigate the mechanisms by which prolonged CI influences the autophagy in the graft lung, in which…
  • 2020 American Transplant Congress

    Nlrp3 Inhibition Improves Heart Graft Function in Donation after Circulatory Death

    S. Toldo, E. Mezzaroma, M. Quader

    Virginia Commonwealth University, Richmond, VA

    *Purpose: Donation after circulatory death (DCD) donors have the potential to increase the number of transplantable hearts, which today relies only on donation after brain…
  • 2020 American Transplant Congress

    Pre-Transplant Monocyte HDAC6 Expression and Risk of Primary Graft Dysfunction in Clinical Lung Transplant Recipients

    T. Akimova1, T. Zhang1, L. Wang1, J. D. Christie2, W. W. Hancock1

    1Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA

    *Purpose: Lung transplantation (Tx) in ~30% of cases is subject to primary graft dysfunction (PGD), the severe acute lung injury that occurs within 72 hours…
  • 2020 American Transplant Congress

    Ferroptotic Cell Death During Cold Storage is Essential in Liver Transplant Injury

    H. Kojima, S. Kageyama, K. Kadono, H. Hirao, K. J. Dery, T. Ito, K. Nakamura, R. W. Busuttil, J. W. Kupiec-Weglinski

    The Dumont-UCLA Transplantation Center, Department of Surgery, Division of Liver and Pancreas Transplantation, David Geffen School of Medicine at UCLA, Los Angeles, CA

    *Purpose: It has been reported that activation of apoptosis signaling-regulating kinase 1 (ASK1)/p-p38 axis during tissue cold storage results in ferroptotic cell death. Ferroptosis is…
  • 2020 American Transplant Congress

    A NASHional Crisis: Liver Transplantation Outcomes in Female Hispanics

    R. A. Sosa1, A. Q. Terry1, M. Rossetti1, F. M. Kaldas2, B. V. Naini1, J. Nevarez-Mejia1, V. M. Groysberg1, S. Younan2, R. W. Busuttil2, D. W. Gjertson1, J. W. Kupiec-Weglinski2, E. F. Reed1

    1Pathology and Lab Medicine, UCLA, Los Angeles, CA, 2Surgery, UCLA, Los Angeles, CA

    *Purpose: Obesity and metabolic syndrome have recently become an epidemic with Hispanics bearing a disproportionate burden. Non-alcoholic steatohepatitis (NASH) is a severe immune-mediated stage of…
  • 2020 American Transplant Congress

    Therapeutic Inhibition of Spleen Tyrosine Kinase Decreases Hepatic Damage after Ischemia Reperfusion Injury

    A. Zarrinpar, V. Boominathan, A. Kobayashi, S. Duarte

    Surgery, University of Florida, Gainesville, FL

    *Purpose: Hepatic ischemia/reperfusion injury (IRI) is a major challenge in transplantation. The complex array of interrelated signaling events in IRI have been studied individually, but…
  • 2020 American Transplant Congress

    New IGL-2 Perfusate in Liver HOPE Strategies

    A. Panisello-Rosello1, C. Castro-Benítez2, E. Folch-Puy1, J. Rosello-Catafau1, R. Adam2

    1Experimental Pathology, Instituto de Investigaciones Biomedicas de Barcelona, Barcelona, Spain, 2Centre Hépato-Billiare, Hôpital Paul Brousse, Paris, France

    *Purpose: HOPE has shown to optimize graft liver preservation. However, the most used perfusion solutions as such as Belzer-MPS and its generics were initially for…
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