2019 American Transplant Congress
FTY720 Regulates Mitochondria Biogenesis in Dendritic Cells to Prevent Kidney Ischemic Reperfusion Injury
*Purpose: FTY720, a S1PR agonist has been shown to protect kidneys from IRI. However, systemic use is limited due to adverse side effects. Dendritic cells…2019 American Transplant Congress
Impact of Time-of-Day of Declamping on Kidney Transplant Outcome
*Purpose: Despite improvements in organ preservation techniques and efforts to minimize the duration of cold ischemia, ischaemia- reperfusion injury remains associated with poor graft function…2019 American Transplant Congress
Erk-elk1-mir-711 Signalling In Cardiac Ischemia Reperfusion Injury In Heart Transplantation
Pathology, University of Western Ontario, London, ON, Canada
*Purpose: This study aims to discover new molecular mechanisms involved in and to develop new treatment for preventing ischemia reperfusion injury in heart transplantation.*Methods: The…2019 American Transplant Congress
Analysis of Lactic Acid Response in Renal Transplant Patients
*Purpose: Lactic acid (LA) serves as an important biomarker in the evaluation of ischemia, sepsis, metabolic acidosis, and trauma. During renal transplantation (RT), there is…2019 American Transplant Congress
CEACAM1 – p38 Signaling Axis Alleviates Peri-Transplant Liver Injury: From Mouse-to-Human
1UCLA, Los Angeles, CA, 2City of Hope, Duarte, CA
*Purpose: Although CEACAM1 (CM1; carcinoembryonic antigen-related cell adhesion molecule 1; CD66a) regulates hepatic metabolism, its role in orthotopic liver transplantation (OLT) is unknown. A recent…2019 American Transplant Congress
Aquaporins May Be Involved in Renal Ischemia-Reperfusion Injury by Affecting the Pyroptosis of Renal Tubular Epithelial Cells
*Purpose: To determine whether aquaporins (AQPs) are involved in renal ischemia-reperfusion injury (IRI) by affecting the pyroptosis of renal tubular epithelial cells.*Methods: Hypoxia reoxygenation (H/R)…2019 American Transplant Congress
Effects of Omega-3 Fatty Acids on Outcome after Living Donor Right Hepatectomy
Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Preclinical data suggest that supplementation of omega-3 fatty acids may be beneficial in liver resections, by ameliorating ischemic injury during the surgical procedure. In…2019 American Transplant Congress
Obesity Induced IL-18 Production Impairs FOXP3+ Treg Function and Increases Risk of Primary Graft Dysfunction in Lung Transplant Recipients
*Purpose: Lung transplantation is a life-saving treatment for terminal lung diseases but long-term outcomes are poor, beginning with possible development of primary graft disease (PGD)…2019 American Transplant Congress
Glycogen Synthase Kinase 3alpha Serine 21 Phosphorylation Inhibits Hepatocyte Autophagy to Facilitate Liver Ischemia Reperfusion Injury
*Purpose: Glycogen synthase kinase 3 (Gsk3) has α and β isoforms. They are constitutively active in cells and inhibited upon stimulations by N-terminal serine phosphorylation.…2019 American Transplant Congress
Pharmacological Mobilization of Host Stem Cells Prevents Delayed Graft Function Following Kidney Transplantation in Rats
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Delayed graft function (DGF) caused by ischemia-reperfusion injury (IRI) is an early complication that occurs in nearly a quarter of all deceased-donor kidneys and…
American Transplant Congress abstracts