2020 American Transplant Congress
Donor Intervention and Recipient Treatment with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function in a Non-Human Primate Model of Kidney Transplantation
*Purpose: There is currently no FDA-approved treatment to prevent delayed graft function (DGF) in kidney transplantation. We have shown that donor or recipient treatment with…2020 American Transplant Congress
The Significance of Donor Gender on Graft Survival and Histological Ischemia Reperfusion Injury in Liver Transplant Patients
Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: Experimental animal models have demonstrated improved ability of females (F) to recover from ischemia-reperfusion injury (IRI) compared with males (M). Recent work combining human…2020 American Transplant Congress
Treprostinil is Safe and Potentially Useful in Preventing Ischemia and Reperfusion Injury in Adult Orthotopic Liver Transplant Recipients
*Purpose: Ischemia and reperfusion injury (IRI) is one of the unavoidable complications in orthotopic liver transplantion. Hepatic ischemic injury begins during the preservation of the…2020 American Transplant Congress
Prolonged Cold Ischemia Increases Reactive Oxygen Species Activates Autophagy by Enhancing Glycolysis in the Graft Through the mTOR Signaling Pathway in Orthotopic Lung Transplantation of Rats
*Purpose: The aim of the present study is to investigate the mechanisms by which prolonged CI influences the autophagy in the graft lung, in which…2020 American Transplant Congress
Nlrp3 Inhibition Improves Heart Graft Function in Donation after Circulatory Death
Virginia Commonwealth University, Richmond, VA
*Purpose: Donation after circulatory death (DCD) donors have the potential to increase the number of transplantable hearts, which today relies only on donation after brain…2020 American Transplant Congress
Pre-Transplant Monocyte HDAC6 Expression and Risk of Primary Graft Dysfunction in Clinical Lung Transplant Recipients
*Purpose: Lung transplantation (Tx) in ~30% of cases is subject to primary graft dysfunction (PGD), the severe acute lung injury that occurs within 72 hours…2020 American Transplant Congress
Ferroptotic Cell Death During Cold Storage is Essential in Liver Transplant Injury
*Purpose: It has been reported that activation of apoptosis signaling-regulating kinase 1 (ASK1)/p-p38 axis during tissue cold storage results in ferroptotic cell death. Ferroptosis is…2020 American Transplant Congress
A NASHional Crisis: Liver Transplantation Outcomes in Female Hispanics
1Pathology and Lab Medicine, UCLA, Los Angeles, CA, 2Surgery, UCLA, Los Angeles, CA
*Purpose: Obesity and metabolic syndrome have recently become an epidemic with Hispanics bearing a disproportionate burden. Non-alcoholic steatohepatitis (NASH) is a severe immune-mediated stage of…2020 American Transplant Congress
Therapeutic Inhibition of Spleen Tyrosine Kinase Decreases Hepatic Damage after Ischemia Reperfusion Injury
Surgery, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is a major challenge in transplantation. The complex array of interrelated signaling events in IRI have been studied individually, but…2020 American Transplant Congress
New IGL-2 Perfusate in Liver HOPE Strategies
*Purpose: HOPE has shown to optimize graft liver preservation. However, the most used perfusion solutions as such as Belzer-MPS and its generics were initially for…
American Transplant Congress abstracts