2022 American Transplant Congress
Timing of Hypotension Post Kidney Transplant Impacts the Risk of Subsequent Delayed Graft Function
1Dalhousie University, Halifax, NS, Canada, 2Nova Scotia Health Authority, Halifax, NS, Canada
*Purpose: Hypotension is common post-kidney transplant and is associated with delayed graft function (DGF; a need for dialysis in the first week post-transplant) and prolonged…2022 American Transplant Congress
Circulating Galectin-3 Levels Increase in Syngeneic Rat Recipients of Vascularized Composite Allografts Subjected to Prolonged Ischemia
*Purpose: During the process of transplantation, organs and tissue are necessarily subjected to some degree of hypoxic and ischemic injury during procurement, preservation and following…2022 American Transplant Congress
Cold Stress-Induced Ferroptosis in Liver Sinusoidal Endothelial Cells Deteriorates Liver Transplant Outcomes
UCLA Medical Center, Los Angeles, CA
*Purpose: While hepatocytes are affected by ischemia-reperfusion injury (IRI) especially under normothermic stress, liver sinusoidal endothelial cells (LSECs) are particularly vulnerable to cold storage-induced IR-insult.…2022 American Transplant Congress
Significant Reduction of Troponin I Elaboration After Ischemia Minimization in the First Hour of Ex Vivo Xeno Heart Perfusion
*Purpose: Previous studies showed that ischemia minimization (IM), accomplished by perfusing the heart xenograft during storage, prevents ‘initial cardiac xenograft dysfunction’ (ICXD) and enables prolonged…2022 American Transplant Congress
Clusterin Protects Kidney Transplants from Ischemia-Reperfusion Injury by Modulating Neutrophil Infiltration
*Purpose: Ischemia-reperfusion injury (IRI) is inevitable during organ transplantation. Clusterin (CLU) has shown to be protective in IRI. Supplementation of storage solution with recombinant CLU…2022 American Transplant Congress
Dynamic Changes and Roles of Specialized Pro-resolving Lipid Meditators in the Initiation and Resolution Process of Lung Ischemia-Reperfusion Injury in Rats
*Purpose: Lung ischemia-reperfusion injury (IRI) is one of the significant complications after lung transplantation, which is a form of acute lung injury by robust inflammation.…2022 American Transplant Congress
Ultrasound Targeted Microbubble Cavitation During Ex Vivo Normothermic Machine Perfusion Reduces Peribiliary Vascular Plexus Thrombi and Graft Injury in a DCD Liver Transplant Model
*Purpose: Thrombus formation in the peribiliary vascular plexus (PBP) is a proposed mechanism for ischemic cholangiopathy (IC) after liver transplantation from donors after circulatory death…2022 American Transplant Congress
Post-Operative Day 1 Galectin-3 is Predictive of Early Allograft Dysfunction in Liver Transplantation
University of Colorado Anschutz Medical, Aurora, CO
*Purpose: Early allograft dysfunction (EAD) is an important outcome measure in liver transplantation that is predictive of graft failure, but the mechanism behind it remains…2022 American Transplant Congress
Cold Ischemia Time is More Critical for Older Donor Kidney Survival: A Machine Learning Approach
*Purpose: Increasing utilization of kidneys from older donors is a potential solution to mitigate the organ shortage. However, older donor age is a risk factor…2022 American Transplant Congress
Impact of Total Parenteral Nutrition on Donor Kidneys During Oxygenated Preservation at 22ºC Ex Vivo
1London Health Sciences Centre, London, ON, Canada, 2Western University, London, ON, Canada
*Purpose: Recent studies have shown that ex vivo preservation at 37 º C can reduce kidney injury compared to current clinical practice. However, to mitigate…
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