Articles tagged "Histocompatibility"

2018 American Transplant Congress
Temporal Variability of IgG Subclasses
D. Pinelli, M. Gopalakrishnan, A. Joong, P. Thrush, A. Tambur.
Northwestern University, Chicago; Lurie Children's Hospital, Chicago.
The temporal model of IgG subclass switching supports sequential IgG conversion; however, the diversity of previously stimulated B cells is known to shape responses in…
2018 American Transplant Congress
Delayed Graft Function in Live Donor HLA-Incompatible Kidney Transplant Recipients: A Multicenter Study
J. Motter,¹ A. Massie,¹ J. Garonzik Wang,¹ K. Jackson,¹ X. Luo,¹ A. Muzaale,¹ B. Orandi,² D. Segev.¹
¹JHU, Baltimore; ²UCSF, San Francisco.
Background: Many patients with a willing, but incompatible live donor choose to undergo incompatible live donor kidney transplantation (ILDKT) facilitated by desensitization procedures to eliminate…
2018 American Transplant Congress
A Novel Endothelial Cell Based Complement Dependent Cytotoxicity Test in Kidney Transplantation
R. Lammerts,¹ J. van den Born,¹ W. Dam,¹ M. Seelen,¹ B. Hepkema,² B. Kroesen,² M. Daha,¹ R. Pol,³ S. Berger,¹ On behalf of the COMBAT Consortium.¹
¹Department of Nephrology, University Medical Centre Groningen, Groningen, Netherlands; ²Department of Immunology, University Medical Centre Groningen, Groningen, Netherlands; ³Department of Surgery, University Medical Centre Groningen, Groningen, Netherlands.
Introduction:Relevant alloantibodies in kidney transplantation comprise anti-HLA antibodies, blood group antibodies (ABO incompatible) and anti-endothelial cell antibodies (AECA) and can initiate antibody-mediated rejection (ABMR). ABMR…
2018 American Transplant Congress
The Brazilian Epitope Virtual Crossmatch Protocol: A Reliable Tool for Increasing Kidney Allocation among Highly Sensitized Patients
L. Sousa,¹ A. Silva,¹ M. Marroquim,¹ A. Coelho,¹ A. Lima,¹ F. Silva,¹ C. Carracosa,² G. Willcox,³ T. Leão,³ B. Correa,³ E. Guimarães,³ G. Maciel,³ J. Andrade,⁴ A. Andrade,⁴ R. Neto,⁴ S. Cavalcante,⁴ C. Leão,⁴ F. Cavalcante,⁵ A. Holanda,⁵ N. Gomes,⁶ A. Rego,⁶ S. Monte.¹
¹UFPI, Teresina, PI, Brazil; ²PUC, Curitiba, PR, Brazil; ³HLA Diagnostico, Recife, PE, Brazil; ⁴IMIP, Recife, PE, Brazil; ⁵RHP, Recife, PE, Brazil; ⁶CNCDO, Recife, PE, Brazil.
Background: In Brazil (BZ), the kidney allocation policy for highly sensitized patients (HS) (PRA ≥ 80%) does not involve prioritization and transplants 10 times less…
2018 American Transplant Congress
A New Reality: Virtual Crossmatch Can Be Used Successfully as Pre-Transplant Compatibility Testing for Most Deceased Donor Transplants at a High Volume Center
R. Rajalingam,¹ D. Gae,¹ Z. Laszik,² G. Roll,³ M. Tavakol,³ C. Freise,³ D. Adey,⁴ A. Webber,⁴ D. Dobi,² K. Cunniffe,¹ G. da Gente,¹ N. Ascher,³ P. Stock,³ J. Roberts.³
¹Immunogenetics and Transplantation Laboratory, Dept. of Surgery, UCSF, San Francisco; ²Dept. of Pathology, UCSF, San Francisco; ³Dept. of Surgery, UCSF, San Francisco; ⁴Dept. of Medicine, UCSF, San Francisco.
Aim: We developed a reliable virtual crossmatch (VXM) method for use as pre-transplant XM for deceased donor (DD) kidney transplantation (KTx). Here we report the…
2018 American Transplant Congress
Acute Antibody Mediated Rejection Treatment Impact on Class I and Class II Anti-HLA Antibodies in Pediatric Kidney Transplant Recipients
E. Kincaide,^1,2,3 K. Hitchman,^1,3 R. Hall,^1,2,3 I. Yamaguchi,³ B. Crowther.^1,2,3
¹University Health System, San Antonio, TX; ²College of Pharmacy, Pharmacotherapy Division, The University of Texas at Austin, Austin, TX; ³UT Health San Antonio, San Antonio, TX.
Purpose: Characterize class I and class II donor specific antibodies (DSA) response to acute antibody mediated rejection (AMR) treatment in pediatric kidney transplant recipients (KTR).Methods:…
2018 American Transplant Congress
Flow DSA-XM: Better Crossmatch or Just Different Problems?
P. Kimball, F. McDougan.
Surgery, VCUHealth Systems, Richmond, VA.
Background. Despite the positive impact of flow crossmatching(FCXM) upon alloantibody detection, its inability to distinguish anti-Class I from Class II or non-HLA from HLA-antibodies remain…
2018 American Transplant Congress
Shortened Cold Ischemia Time and Reduced Incidence of Delayed Graft Function for Kidney Transplants through Enhanced Tissue Compatibility Testing
I. Helanterä,¹ T. Saarinen,² J. Peräsaari,² M. Lempinen,¹ J. Lauronen.²
¹Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland; ²Histocompatibility Laboratory, Finnish Red Cross Blood Service, Helsinki, Finland.
A. HLA-typing and prospective leukocyte cross-matching needed for deceased donor kidney transplantation (kTX) may delay the onset of surgery. We compared cold ischemia times (CIT)…
2018 American Transplant Congress
Selection and Stratification of Anti-HLA-A and HLA-B Sensitized Patients in Pig-to-Human Xenotransplantation
G. Martens,¹ J. Ladowski,¹ J. Butler,² L. Reyes,¹ M. Tector,¹ A. Tector.¹
¹University of Alabama at Birmingham, Birmingham, AL; ²Indiana University School of Medicine, Indianapolis, IN.
Introduction: Patients with anti-HLA-A and –B antibodies are difficult to match and represent a possible population for inclusion in pig-to-human xenotransplantation clinical trials. Donor specific…
2018 American Transplant Congress
Increasing the Donor Pool for Highly Sensitized Patients with Allele Specific Antibodies: Optimizing the Virtual Crossmatch (vXM)
A. Zhang,¹ Z. Zaky,² J. Africa,³ D. Good,¹ R. Bray,⁴ H. Gebel.⁴
¹Allogen Laboratories, Cleveland Clinic, Cleveland; ²Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland; ³Transplant Surgery, Charleston Area Medical Center, Charleston; ⁴Pathology & Laboratory Medicine, Emory University, Atlanta.
Background:Since implementation of the current Kidney Allocation System, highly sensitized patients with 98-100% cPRA (HSPs) are receiving ~10% of deceased donor kidneys compared to <2%…